Clinical Trials

Numerous clinical trials evaluate Ciprofloxacin across Early Phase 1 through Phase 4 and non-interventional designs for diverse infectious and inflammatory conditions, including Staphylococcus aureus skin, chest, and urinary tract infections, Neisseria gonorrhoeae, acute otitis externa, rhinoscleroma, and colonic Crohn's disease. Reflecting completed, active, and terminated recruitment statuses, these studies are supported by pharmaceutical developers, such as Bayer, Otonomy, and Exela Pharma Sciences, alongside academic and clinical institutions including the University of Washington and Mount Sinai Hospital.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06728072 RECRUITING
Colorectal Cancer; CRC
Virginia Commonwealth University
 2025-03-07 PHASE2
NCT06810583 RECRUITING
Leukemia; Acute Myeloid Leukemia; Lymphoblastic Leukemia in Children
St. Jude Children's Research Hospital
 2025-05-22 PHASE1
NCT07028424 NOT_YET_RECRUITING
PDAC - Pancreatic Ductal Adenocarcinoma
GERCOR - Multidisciplinary Oncology Cooperative Group
 2025-07 PHASE2
NCT07704359 NOT_YET_RECRUITING
Perianal Abscess; Anal Fistula
University of Illinois at Chicago
 2026-08-03 PHASE4
NCT07625267 WITHDRAWN
Acute Uncomplicated Diverticulitis
Montefiore Medical Center
 2026-07-01 PHASE4
NCT07788404 RECRUITING
Prosthetic Joint Infection; Osteomyelitis; Staphylococcal Infections
Groupe Hospitalier Diaconesses Croix Saint-Simon
 2023-06-10
NCT07483736 NOT_YET_RECRUITING
C15.378
Versailles Hospital
 2026-03 PHASE3
NCT04678869 ACTIVE_NOT_RECRUITING
Acute Lymphoblastic Leukaemia - Category
University College, London
 2022-06-29
NCT05100654 ACTIVE_NOT_RECRUITING
Erectile Dysfunction; Penile Prosthesis Infection
University of Chicago
 2022-04-22 EARLY_PHASE1
NCT05224401 RECRUITING
Urinary Tract Infections; Bacteremia; Antibiotic Resistant Infection
Lund University
 2023-05-29 PHASE3
NCT06926322 ENROLLING_BY_INVITATION
Pain, Postoperative; Root Resorption; Persistent Infection; Necrotic Pulp
Ain Shams University
 2025-10
NCT05462496 RECRUITING
Pancreatic Cancer
Icahn School of Medicine at Mount Sinai
 2023-03-16 PHASE2
NCT05846399 RECRUITING
Cat Bite; Hand Injuries; Arm Injury; Infection, Bacterial; Anti-bacterial Agents
University of Missouri-Columbia
 2023-09-07 PHASE4
NCT05678621 RECRUITING
Haematological Malignancy; Hypogammaglobulinemia
Monash University
 2022-11-30 PHASE2; PHASE3
NCT04791579 RECRUITING
Neurogenic Bladder; Post-operative Urinary Tract Infections
University of Alberta
 2025-02-01 PHASE2
NCT04523987 ACTIVE_NOT_RECRUITING
Metastatic Pancreatic Ductal Adenocarcinoma
National University Hospital, Singapore
 2019-02-22 PHASE1
NCT06709196 RECRUITING
Cystectomy; Bladder Cancer Requiring Cystectomy; Postoperative Infections; Antibiotic Prophylaxis; Ileal Conduit
Rigshospitalet, Denmark
 2025-01-07 PHASE4
NCT07772752 RECRUITING
Drug-induced Crystalline Nephropathy; Drug-induced Crystalluria; Infections Treated With Sulfamethoxazole, High Dose Ciprofloxacin or High Dose iv Amoxicillin
Universitair Ziekenhuis Brussel
 2025-12-08
NCT05398679 RECRUITING
Endocarditis Infective
Fundacion Clinic per a la Recerca Biomédica
 2022-08-17 PHASE4
NCT06426836 RECRUITING
Pharmacokinetics; Amoxicillin-clavulanate; Piperacillin-tazobactam; Meropenem; Cefazolin; Teicoplanin; Vancomycin; Ciprofloxacin; Amikacin
University Hospital, Ghent
 2016-08-19
NCT04444440 RECRUITING
Idiopathic Overactive Bladder; Postoperative Urinary Tract Infection
University of Alberta
 2021-06-28 PHASE4
NCT06126731 RECRUITING
Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Institute of Cancer Research, United Kingdom
 2023-11-02 PHASE1; PHASE2
NCT05199324 COMPLETED
Gram-negative Bacteraemia
Tan Tock Seng Hospital
 2022-06-03 PHASE4
NCT05959616 RECRUITING
Shigellosis
University of Oxford
 2025-01-21 PHASE1
NCT07552870 COMPLETED
Cirrhosis
Shahida Islam Medical Complex
 2026-01-15
NCT05294588 COMPLETED
Gonorrhea Male
University of North Carolina, Chapel Hill
 2022-04-18 PHASE2
NCT03630081 UNKNOWN
Complicated Urinary Tract Infection; Acute Pyelonephritis
Wockhardt
 2024-01 PHASE3
NCT05286931 RECRUITING
Neisseria Gonorrhoeae Infection
University of Washington
 2022-03-03
NCT04948463 COMPLETED
Febrile Neutropenia
Murdoch Childrens Research Institute
 2021-11-15 PHASE4
NCT07016165 RECRUITING
Neutropenic Fever; Acute Lymphoblastic Leukemia; Acute Myeloblastic Leukemia; Non Hodgkin Lymphoma
Gadjah Mada University
 2025-06-01 PHASE4
NCT06798402 RECRUITING
Cutaneous Leishmaniasis
Al-Mustafa University College
 2025-02-07 PHASE2
NCT06093191 COMPLETED
Bronchiectasis Adult; Pseudomonas Aeruginosa Infection
Jin-Fu Xu
 2023-10-18 PHASE4
NCT06342830 COMPLETED
Periapical Disease
Ain Shams University
 2024-06-20 PHASE2
NCT06968286 COMPLETED
Periodontitis Stage II
Suez Canal University
 2025-01-01
NCT07150065 COMPLETED
Typhoid; Fever
Avicenna Medical College Lahore
 2025-02-07 PHASE2
NCT07188935 COMPLETED
T2DM (Type 2 Diabetes Mellitus)
Al-Mustansiriyah University
 2024-10-30
NCT04698057 WITHDRAWN
Febrile Neutropenia
Poitiers University Hospital
 2022-03-01 PHASE3
NCT05274672 WITHDRAWN
Benign Prostatic Hyperplasia; Urinary Tract Infections
Baylor Research Institute
 2023-03-01 PHASE4
NCT05977868 TERMINATED
Endovascular Infection; Bone and Joint Infection; Skin and Soft Tissue Infection; Pulmonary Infection; Gastrointestinal Infection; Genitourinary Infection
West Virginia University
 2023-08-04 PHASE4
NCT02944825 COMPLETED
Urolithiasis; UTI
University of California, San Diego
 2016-01
NCT05385887 UNKNOWN
Perianal Fistula; Perianal Abscess; Drain Abscess
dr. IJM Han-Geurts
 2021-12-23
NCT03692715 COMPLETED
Ureteral Stones; Ureteral Calculi; Nephrolithiasis
Clinical Urology and Epidemiology Working Group
 2018-09-27 PHASE4
NCT03850379 COMPLETED
Prophylaxis; Stem Cell Transplant Complications
Henry Ford Health System
 2018-03-14 PHASE2
NCT03012360 TERMINATED
Mechanical Ventilation Complication; Critical Illness
University Hospital, Lille
 2018-02-08 PHASE4
NCT07616635 COMPLETED
Haematopoietic Stem Cell Transplantation; Acute Leukemia
Fundación para la Investigación Biosanitaria del Principado de Asturias
 2022-03-14 PHASE3
NCT04110340 COMPLETED
Plague, Bubonic; Plague, Pneumonic
University of Oxford
 2020-02-15 PHASE3
NCT05804123 COMPLETED
Upper Respiratory Tract Infections
Anabio R&D
 2021-10-28
NCT05311254 UNKNOWN
Febrile Neutropenia
Fundación para la Investigación Biosanitaria del Principado de Asturias
 2022-03-14 PHASE3
NCT05863832 UNKNOWN
Surgical Site Infections
MinaPharm Pharmaceuticals
 2021-08-17 PHASE4
NCT02375295 UNKNOWN
Kidney Stones
University of British Columbia
 2015-03 PHASE4
NCT06234046 COMPLETED
Spontaneous Bacterial Peritonitis
Ain Shams University
 2023-05-28 PHASE3
NCT05828550 COMPLETED
Patients withInfections Caused by S.Aureus Like Skin Infections , Chest Infections , Surgical Site Infections , and Urinary Tract Infections
Sohag University
 2023-05-01
NCT05844735 COMPLETED
Rheumatoid Arthritis
Sanofi
 2023-05-22 PHASE1
NCT05287425 COMPLETED
Nasal and Pharyngeal Microbiome
Medical University of Vienna
 2019-08-12 PHASE2
NCT05843708 COMPLETED
Healthy Subjects
Servier Bio-Innovation LLC
 2023-04-14 PHASE1
NCT05431673 UNKNOWN
Rhinoscleroma
Assiut University
 2022-08-21 PHASE1
NCT05828550 Not yet recruiting
Patients withInfections Caused by S.Aureus Like Skin Infections Chest Infections Surgical Site Infections and Urinary Tract Infections
Sohag University
 2023-05 Not Applicable
NCT03262142 TERMINATED
COPD; Respiratory Tract Infections; Pseudomonas Aeruginosa; Bronchiectasis; Asthma
Chronic Obstructive Pulmonary Disease Trial Network, Denmark
 2018-01-10 PHASE4
NCT03939273 UNKNOWN
Systemic Inflammatory Response Syndrome; Postoperative Shock; Coronary Artery Disease; Extracorporeal Circulation; Complications
Radboud University Medical Center
 2022-03
NCT04549311 COMPLETED
Perianal Abscess; Perianal Fistula
Sunnybrook Health Sciences Centre
 2021-11-18 PHASE3
NCT05162625 UNKNOWN
Endophthalmitis; Open Globe Injury; Moxifloxacin; Post-Traumatic Endophthalmitis
University of Campinas, Brazil
 2021-12-10 PHASE2
NCT04171466 COMPLETED
Antibiotic Side Effect; Antibiotic-associated Diarrhea; Antibiotic-induced Dysbiosis; Antibiotic-induced Epithelial Barrier Disintegrity
Seed Health
 2020-08-12
NCT05436678 COMPLETED
Pharmacokinetics
NeuroSense Therapeutics Ltd.
 2022-07-26 PHASE1
NCT05232461 COMPLETED
Pharmacokinetics
NeuroSense Therapeutics Ltd.
 2022-04-08 PHASE1
NCT05442736 COMPLETED
Antibiotic Resistant Infection
British University In Egypt
 2022-04-02 EARLY_PHASE1
NCT03643198 UNKNOWN
Anal Fistula; Anal Abscess
Germans Trias i Pujol Hospital
 2022-03-01
NCT05286931 Recruiting
Neisseria Gonorrhoeae Infection
University of Washington
 2022-03-03 Not Applicable
NCT04636957 UNKNOWN
Acute Otitis Externa
Lee's Pharmaceutical Limited
 2020-11 PHASE3
NCT03507556 ACTIVE_NOT_RECRUITING
Revascularization
Jordan University of Science and Technology
 2010-06-28
NCT03173053 TERMINATED
Staphylococcus Aureus; Motility Disorder
Radboud University Medical Center
 2018-02-08
NCT04090684 COMPLETED
ALS (Amyotrophic Lateral Sclerosis)
NeuroSense Therapeutics Ltd.
 2019-12-09 PHASE1
NCT03228108 COMPLETED
Complication; Infection; Prostate Cancer
Radboud University Medical Center
 2018-04-03 PHASE4
NCT02773732 TERMINATED
Leukemia; Acute Myelogenous Leukemia; Acute Myeloid Leukemia
University of Florida
 2016-12-16 PHASE1; PHASE2
NCT04374188 UNKNOWN
Nephrolithiasis
Diaa Eldin Taha Ramadan Mohamed
 2019-09-01
NCT02620007 TERMINATED
Crohn Disease; Adherent-invasive E. Coli
Assistance Publique - Hôpitaux de Paris
 2015-12 PHASE2
NCT03327844 COMPLETED
Infected Immature Permanent Teeth
National University Health System, Singapore
 2017-03-01 PHASE2
NCT03177720 COMPLETED
Pneumonia
Medical University of Vienna
 2016-05-29 PHASE1
NCT03985514 COMPLETED
Appendicitis
Göteborg University
 2018-05-15 PHASE4
NCT04763070 COMPLETED
Epilepsy Intractable
Mazandaran University of Medical Sciences
 2020-10-01
NCT03854929 COMPLETED
Dysentery, Shigella; Shigellosis; Diarrhea
Oxford University Clinical Research Unit, Vietnam
 2019-12-11 PHASE4
NCT04165850 COMPLETED
Amyotrophic Lateral Sclerosis; ALS
NeuroSense Therapeutics Ltd.
 2019-11-25 PHASE2
NCT03476317 COMPLETED
Crohn Disease
Children's Hospital of Philadelphia
 2018-07-12 PHASE2
NCT05532267 COMPLETED
Healthy Subjects
Future University in Egypt
 2020-11-04 PHASE1
NCT04575493 COMPLETED
Urinary Tract Infections
Islamia University of Bahawalpur
 2020-10-05
NCT02717871 COMPLETED
Keratitis; Infectious Disease (Manifestation)
University Hospital, Geneva
 2016-03 PHASE3
NCT02358993 COMPLETED
Urinary Tract Infections; Catheter-Related Infections
University of Pennsylvania
 2014-12
NCT04147260 COMPLETED
Healthy
Boehringer Ingelheim
 2019-11-06 PHASE1
NCT02790138 COMPLETED
Pouchitis
Takeda
 2016-10-12 PHASE4
NCT03891979 WITHDRAWN
Pancreatic Cancer
NYU Langone Health
 2019-06-25 PHASE4
NCT03969758 UNKNOWN
Liver Abscess
Post Graduate Institute of Medical Education and Research, Chandigarh
 2019-07 PHASE3
NCT02734732 UNKNOWN
Prostate Infection
Umeå University
 2015-04 PHASE2
NCT05475444 COMPLETED
Bacterial Infections Oral
British University In Egypt
 2020-03-01
NCT02800785 COMPLETED
Appendicitis
University of Washington
 2016-05
NCT04067011 COMPLETED
Anthrax
Emergent BioSolutions
 2019-08-12 PHASE2
NCT02816112 COMPLETED
Early Stage Breast Cancer
Ottawa Hospital Research Institute
 2016-09 PHASE4
NCT03862170 TERMINATED
Prostate Cancer
CR-CSSS Champlain-Charles-Le Moyne
 2015-02-10 PHASE3
NCT03354598 COMPLETED
Uncomplicated Urinary Tract Infections
Iterum Therapeutics, International Limited
 2018-08-01 PHASE3
NCT03357614 COMPLETED
Complicated Urinary Tract Infections
Iterum Therapeutics, International Limited
 2018-09-18 PHASE3
NCT02532192 WITHDRAWN
Lymphoma
M.D. Anderson Cancer Center
 2015-12 PHASE1
NCT03840811 COMPLETED
Gonococcal Infection
National Institute of Allergy and Infectious Diseases (NIAID)
 2017-04-23 PHASE1
NCT04204954 COMPLETED
Demodex Infestation; Demodicosis; Cataract
Hospital de La Luz
 2019-05-06 PHASE2; PHASE3
NCT03358576 COMPLETED
Intra Abdominal Infections
Iterum Therapeutics, International Limited
 2018-09-18 PHASE3
NCT03431675 WITHDRAWN
Meningitis, Meningococcal
Epicentre
 2019-03-01 PHASE4
NCT03027635 TERMINATED
Cirrhosis; Ascites Hepatic; Ascites (Non-Malignant)
Nina Kimer
 2017-01-20
NCT01783106 COMPLETED
Crohn's Disease
Royal Liverpool University Hospital
 2014-02-01 PHASE2
NCT02300220 COMPLETED
Chronic Obstructive Pulmonary Disease (COPD)
Imperial College London
 2014-05-05 PHASE3
NCT02961751 COMPLETED
Gonococcal Infection
National Institute of Allergy and Infectious Diseases (NIAID)
 2016-10-19
NCT03716804 COMPLETED
Uncomplicated Urinary Tract Infection; Antibiotic Resistant Infection
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
 2018-06-06 PHASE4
NCT02765256 COMPLETED
Crohn's Disease
University of Pennsylvania
 2016-08 PHASE2
NCT04456712 COMPLETED
QTc Prolongation, Hyperglycemia, Hypoglycemia
Beni-Suef University
 2018-06-01 PHASE4
NCT03326050 UNKNOWN
Rhinoscleroma
Assiut University
 2018-02 EARLY_PHASE1
NCT03366207 COMPLETED
UTI - Lower Urinary Tract Infection; Antibiotic Resistant Infection
Iterum Therapeutics, International Limited
 2017-12-15 PHASE4
NCT02261896 COMPLETED
Pancreatic Cystic Lesion
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
 2014-10 PHASE4
NCT01265173 COMPLETED
SBP; Liver Cirrhosis
Korea University
 2007-04 PHASE4
NCT01723150 COMPLETED
Liver Abscess, Pyogenic
National University Hospital, Singapore
 2013-11-05 PHASE4
NCT02458781 UNKNOWN
Small Intestinal Bacterial Overgrowth
San Antonio Military Medical Center
 2015-01 PHASE4
NCT02947763 COMPLETED
Periapical Periodontitis
Cairo University
 2016-11 PHASE1
NCT02304822 UNKNOWN
Kidney Stones
Guohua Zeng
 2014-08
NCT03533231 COMPLETED
Dental Pulp Necrosis; Periapical Abscess; Root Canal Infection
Tariq Yehia
 2015-01-16 PHASE4
NCT02173262 COMPLETED
Breast Cancer
Ottawa Hospital Research Institute
 2014-08 PHASE4
NCT03150082 COMPLETED
Infections, Bacterial
GlaxoSmithKline
 2017-08-01 PHASE1
NCT07113587 COMPLETED
Peritoneal Dialysis-associated Peritonitis; Peritoneal Dialysis (PD); Pharmacokinetics; Intravenous Administration; Intravenous; Meropenem; Intraperitoneal; Ampicillin; Aztreonam; Ciprofloxacin; Minimum Inhibitory Concentration (MIC)
Karl Landsteiner Insitute for Nephrology and Haemato-Oncology
 2014-04-08 PHASE2; PHASE3
NCT02724046 COMPLETED
Meningitis, Meningococcal
Epicentre
 2017-04-22 PHASE4
NCT02598362 COMPLETED
Urinary Tract Infection; Pyelonephritis
University Hospital, Ghent
 2015-04 PHASE4
NCT01789203 COMPLETED
BK Virus Infection
The Methodist Hospital Research Institute
 2013-01 PHASE4
NCT02505581 COMPLETED
Surgical Wound Infection
Hospital Universitari Vall d'Hebron Research Institute
 2015-05 PHASE4
NCT02967341 UNKNOWN
Childhood Cancer; Neutropenia
Universitair Ziekenhuis Brussel
 2016-03 PHASE4
NCT02423759 COMPLETED
Benign Prostate Hyperplasia
Mansoura University
 2015-04 PHASE4
NCT02326103 COMPLETED
Alcoholic Hepatitis; Alcoholic Cirrhosis
University of Helsinki
 2015-04 EARLY_PHASE1
NCT02357407 COMPLETED
Infection
Rennes University Hospital
 2015-06 PHASE4
NCT02801370 COMPLETED
Acute Otitis Externa; Swimmer's Ear
Otonomy, Inc.
 2016-06 PHASE3
NCT02106832 COMPLETED
Bronchiectasis
Bayer
 2014-04-30 PHASE3
NCT01515007 COMPLETED
Non Cystic Fibrosis Bronchiectasis
Aradigm Corporation
 2014-03-31 PHASE3
NCT02104245 COMPLETED
Non Cystic Fibrosis Bronchiectasis
Aradigm Corporation
 2014-05-28 PHASE3
NCT02600559 COMPLETED
Otitis Media
Otonomy, Inc.
 2015-10 PHASE3
NCT02252978 WITHDRAWN
Prostate Cancer
Wake Forest University Health Sciences
 2016-07 PHASE2
NCT01888822 TERMINATED
Cholelithiasis
University of Roma La Sapienza
 2013-06 PHASE4
NCT02719158 COMPLETED
Acute Otitis Media; AOMT
Otonomy, Inc.
 2016-02 PHASE2
NCT02223338 COMPLETED
Bacterial Resistance
Loma Linda University
 2014-10
NCT02247960 TERMINATED
Prostate Cancer; Urinary Tract Infection; Clostridium Difficile
University of Rochester
 2014-07
NCT02661438 COMPLETED
Bronchiectasis; Pulmonary Disease, Chronic Obstructive
Bayer
 2016-01-12
NCT01764841 COMPLETED
Bronchiectasis
Bayer
 2013-05-02 PHASE3
NCT01803191 COMPLETED
Urinary Tract Infections
Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
 2012-08 PHASE4
NCT02068846 COMPLETED
HIV; Salivary Gland Disease; Benign Lymphoepithelial Lesion
University of North Carolina, Chapel Hill
 2014-04 PHASE3
NCT01208922 COMPLETED
Traveler's Diarrhea
Dr. Falk Pharma GmbH
 2010-11 PHASE3
NCT01873690 TERMINATED
Urolithiasis
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
 2013-11 PHASE3
NCT02011841 WITHDRAWN
Spontaneous Bacterial Peritonitis
Seoul National University Hospital
 2014-01 PHASE3
NCT02127749 COMPLETED
Endotoxemia
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
 2014-06
NCT02511561 COMPLETED
Otitis Externa
Otonomy, Inc.
 2015-07 PHASE2
NCT02216071 COMPLETED
Acute Otitis Externa
Exela Pharma Sciences, LLC.
 2014-07-20 PHASE3
NCT01659866 COMPLETED
Infection
Northwestern University
 2012-08 PHASE4
NCT01505634 COMPLETED
Urinary Tract Infections; Pyelonephritis
Merck Sharp & Dohme LLC
 2012-05-16 PHASE2
NCT01542801 COMPLETED
Adverse Reaction to Other Drugs and Medicines
Korea University
 2011-08 PHASE4
NCT04870138 COMPLETED
Gonococcal Infection
National Institute of Allergy and Infectious Diseases (NIAID)
 2013-03-10 PHASE1
NCT01994642 TERMINATED
Otitis Media in Patients With Tympanostomy Tubes
Par Pharmaceutical, Inc.
 2013-11 PHASE3
NCT01561794 COMPLETED
Pneumonia
Bayer
 2012-05 PHASE3
NCT01910155 TERMINATED
Otitis Externa
Par Pharmaceutical, Inc.
 2013-07 PHASE3
NCT03045185 COMPLETED
Tooth Injuries; Endodontically Treated Teeth
University of Leeds
 2013-01-01
NCT01279252 COMPLETED
Chronic Lymphocytic Leukaemia (CLL)
King's College Hospital NHS Trust
 2011-07 PHASE2
NCT00980876 COMPLETED
Otitis Externa
Farmoquimica S.A.
 2012-04 PHASE3
NCT02196740 UNKNOWN
Periapical Diseases
Lin Jiacheng
 2013-06
NCT02036528 TERMINATED
Diabetic Foot Ulcers
Royer Biomedical, Inc.
 2014-01 PHASE1; PHASE2
NCT01929460 COMPLETED
Pancreatic Cysts
Kaiser Permanente
 2014-01
NCT01519310 COMPLETED
Nutrition
The Cleveland Clinic
 2010-04 EARLY_PHASE1
NCT02114671 WITHDRAWN
Healthy
Boehringer Ingelheim
 2014-04 PHASE1
NCT01344512 COMPLETED
Pediatrics; Ceftazidime; Ciprofloxacin; Voriconazole
University Hospital, Bordeaux
 2011-06
NCT01595438 COMPLETED
Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis
Pfizer
 2012-10 PHASE3
NCT01908803 TERMINATED
Acute Otitis Media
Alcon Research
 2013-12 PHASE2
NCT01599806 COMPLETED
Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis
Pfizer
 2012-10 PHASE3
NCT02118909 COMPLETED
Healthy Volunteers; Non-smokers
Helsinn Healthcare SA
 2014-05 PHASE1
NCT01928433 COMPLETED
Urinary Tract Infections; Acute Pyelonephritis
MerLion Pharmaceuticals GmbH
 2012-12 PHASE2
NCT01952444 COMPLETED
Inhalational Anthrax
Elusys Therapeutics
 2013-10-29 PHASE1
NCT02015507 COMPLETED
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated
 2014-01 PHASE1
NCT01649635 COMPLETED
Prostate Cancer
Sanofi
 2012-07 PHASE4
NCT00411736 COMPLETED
Cystic Fibrosis
Rigshospitalet, Denmark
 2008-05 PHASE4
NCT01785641 COMPLETED
Peritonitis
Chulalongkorn University
 2012-12
NCT00992329 COMPLETED
Healthy
University of Maryland, Baltimore
 2013-01 PHASE1
NCT01768663 COMPLETED
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated
 2013-01 PHASE1
NCT02340182 COMPLETED
Healthy; Sepsis
W.J. Wiersinga, MD, PhD
 2013-03
NCT01753115 COMPLETED
Anthrax
Emergent BioSolutions
 2012-12 PHASE2
NCT01772615 COMPLETED
Ulcerative Colitis
Hvidovre University Hospital
 2011-05 PHASE4
NCT01059890 COMPLETED
Bacterial Infection; Brain Injury
Poitiers University Hospital
 2009-09 PHASE1
NCT01243437 COMPLETED
Plague
Centers for Disease Control and Prevention
 2010-12 PHASE2
NCT00809913 COMPLETED
Urinary Tract Infection
Leiden University Medical Center
 2008-12 PHASE4
NCT01319435 COMPLETED
Pharmacokinetics of Ciprofloxacin in Neonates
Liverpool Women's NHS Foundation Trust
 2011-01 PHASE1
NCT01538667 COMPLETED
Respiratory System
Bayer
 2012-04 PHASE1
NCT01733966 TERMINATED
Diverticular Sigmoïditis
Quanta Medical
 2010-05 PHASE3
NCT03380403 COMPLETED
Diabetic Foot Infection; Osteomyelitis; Photo Antimicrobial Chemotherapy
Faculdade de Medicina do ABC
 2010-01-01
NCT01386593 COMPLETED
Metabolic Detoxication, Phase I
University Hospital, Basel, Switzerland
 2011-05 PHASE1
NCT01749605 COMPLETED
Uncomplicated Bacterial Cystitis
University of Iowa
 2010-10 PHASE4
NCT01359098 COMPLETED
Otitis Externa; Otorhinolaryngologic Diseases; Ear Diseases; Otitis
Otic Pharma
 2011-07 PHASE2
NCT00609973 COMPLETED
Crohn's Disease
University of North Carolina, Chapel Hill
 2008-05 PHASE2
NCT00736983 COMPLETED
Crohn's Disease With Perianal Fistulas
Foundation for Liver Research
 2008-09 PHASE3
NCT01402947 COMPLETED
Healthy
Shire
 2011-07-25 PHASE1
NCT00873626 COMPLETED
Urinary Tract Infection; Fever
Assistance Publique - Hôpitaux de Paris
 2009-06 PHASE4
NCT00596453 TERMINATED
Prostate Infections
Johns Hopkins University
 2008-01 PHASE4
NCT00840294 TERMINATED
Elevated Prostate Specific Antigen
University of Chicago
 2009-01 PHASE3
NCT01124799 COMPLETED
Hepatitis C Virus
Tibotec Pharmaceuticals, Ireland
 2010-07 PHASE1
NCT00889967 COMPLETED
Non-Cystic Fibrosis Bronchiectasis
Aradigm Corporation
 2010-02 PHASE2
NCT00002850 COMPLETED
Infection; Multiple Myeloma
Gary Morrow
 1997-03 PHASE3
NCT01137903 UNKNOWN
Osteomyelitis; Diabetic Foot; Diabetic Foot Ulcers
Universidad Complutense de Madrid
 2010-04
NCT01108601 UNKNOWN
Hearing Loss
McGill University Health Centre/Research Institute of the McGill University Health Centre
 2008-04 PHASE1; PHASE2
NCT00645788 COMPLETED
Cystic Fibrosis
Bayer
 2008-05 PHASE2
NCT01157819 COMPLETED
Otitis Externa; Otorhinolaryngologic Diseases; Ear Diseases; Otitis
Otic Pharma
 2010-07 PHASE2
NCT00910351 COMPLETED
Pseudomonas Infection
Bayer
 2009-07 PHASE1
NCT00832286 COMPLETED
Dysbacteriosis
National Institute of Allergy and Infectious Diseases (NIAID)
 2009-07-23 PHASE1
NCT00930982 COMPLETED
Bronchiectasis
Bayer
 2009-06 PHASE2
NCT01168895 COMPLETED
Infection; Pulmonary Disease, Chronic Obstructive
Bayer
 2010-07 PHASE1
NCT01400750 COMPLETED
Cystic Fibrosis
Universitaire Ziekenhuizen KU Leuven
 2001-08 PHASE4
NCT00945802 TERMINATED
Acute Otitis Externa
Shire
 2009-07-31 PHASE3
NCT00445497 UNKNOWN
Brain and Central Nervous System Tumors; Lymphoma; Neutropenia; Psychosocial Effects of Cancer and Its Treatment; Small Intestine Cancer; Unspecified Adult Solid Tumor, Protocol Specific
Clatterbridge Centre for Oncology
 2007-07 PHASE3
NCT00961675 COMPLETED
Acute Otitis Externa
Shire
 2009-08-31 PHASE3
NCT01072942 COMPLETED
Pulmonary Disease, Chronic Obstructive
Bayer
 2010-01 PHASE1
NCT00654108 COMPLETED
Gastroenteritis Escherichia Coli
National Institute of Allergy and Infectious Diseases (NIAID)
 2008-06-02 PHASE1
NCT00961038 COMPLETED
Pulmonary Disease, Chronic Obstructive
Bayer
 2009-08 PHASE1
NCT00964561 SUSPENDED
Anthrax
PharmAthene, Inc.
 2009-08 PHASE1
NCT00598403 COMPLETED
Urinary Tract Infections
Tedec-Meiji Farma, S.A.
 2007-11 PHASE3
NCT00137787 COMPLETED
Febrile Neutropenia
Center for Supporting Hematology-Oncology Trials
 2005-04 PHASE3
NCT00805558 COMPLETED
Chronic Periodontitis
Facultad Nacional de Salud Publica
 2009-02 PHASE4
NCT00872209 COMPLETED
Otitis Externa; Otorhinolaryngologic Diseases; Ear Diseases; Otitis
Otic Pharma
 2009-05 PHASE1; PHASE2
NCT01052298 COMPLETED
Disease, Pulmonary
Bayer
 2009-04 PHASE1
NCT00097773 COMPLETED
Cystic Fibrosis; Pulmonary Disease, Chronic Obstructive
Seattle Children's Hospital
 2004-09 PHASE2
NCT00722735 COMPLETED
Urinary Tract Infections
MerLion Pharmaceuticals GmbH
 2008-10 PHASE2
NCT00194532 COMPLETED
Urinary Tract Infection
University of Washington
 2005-06
NCT00355602 COMPLETED
Colitis, Ulcerative
University of Dundee
 2006-07
NCT00741052 COMPLETED
Cholera
International Centre for Diarrhoeal Disease Research, Bangladesh
 2007-07 PHASE3
NCT00785980 COMPLETED
Healthy
Mutual Pharmaceutical Company, Inc.
 2008-09 PHASE1
NCT00688272 COMPLETED
Purpura, Thrombocytopaenic, Idiopathic
GlaxoSmithKline
 2008-06-02 PHASE1
NCT00257699 TERMINATED
Crohn's Disease
Mount Sinai Hospital, Canada
 2006-05 PHASE2
NCT01729195 COMPLETED
Ankle Fracture
Turku University Hospital
 2006-03 PHASE2
NCT00431028 TERMINATED
Inflammation; Bacterial Infections
Federal University of São Paulo
 2005-09 PHASE1; PHASE2
NCT00761462 COMPLETED
Infectious Diseases
Bayer
 1999-10 PHASE3
NCT00294749 TERMINATED
Men Who Must Undergo a Prostate Biopsy Related to Prostate Cancer Suspicion.
Poitiers University Hospital
 2006-02 PHASE3
NCT00107081 TERMINATED
Fever; Neutropenia; Cancer
Swiss Pediatric Oncology Group
 2004-01 PHASE3
NCT00139230 COMPLETED
Squamous Cell Carcinoma; Carcinoma of Head/Neck
Dana-Farber Cancer Institute
 1997-01 PHASE2
NCT00062231 TERMINATED
Chronic Myeloproliferative Disorders; Fever, Sweats, and Hot Flashes; Infection; Leukemia; Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Neoplasms; Neutropenia; Precancerous Condition; Unspecified Adult Solid Tumor, Protocol Specific
European Organisation for Research and Treatment of Cancer - EORTC
 2002-04
NCT00719056 COMPLETED
Total Hip and Knee Arthroplasties
University of Athens
 2004-08 PHASE4
NCT00649155 COMPLETED
Healthy
Mylan Pharmaceuticals Inc
 2005-11 PHASE1
NCT00650351 COMPLETED
Healthy
Mylan Pharmaceuticals Inc
 2005-10 PHASE1
NCT00649662 COMPLETED
Healthy
Mylan Pharmaceuticals Inc
 2005-10 PHASE1
NCT00190151 TERMINATED
Healthy Volunteers
Assistance Publique - Hôpitaux de Paris
 2004-09
NCT00791505 COMPLETED
Chronic Obstructive Pulmonary Disease; Sepsis; Antibiotics
University of Monastir
 2002-07 PHASE3
NCT00651586 COMPLETED
Acute Bacterial Corneal Ulcers; Bacterial Keratitis
Allergan
 2003-10 PHASE2
NCT01372345 COMPLETED
Fasting
Dr. Reddy's Laboratories Limited
 2005-02 PHASE1
NCT01372358 COMPLETED
Fed
Dr. Reddy's Laboratories Limited
 2005-01 PHASE1
NCT00668044 COMPLETED
Burns; Bacterial Infections
Bayer
 2002-11 PHASE3
NCT04552431 COMPLETED
Chronic Prostatitis With Chronic Pelvic Pain Syndrome
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 1997-09-30 PHASE2
NCT00003824 TERMINATED
Bladder Cancer
SWOG Cancer Research Network
 1999-04 PHASE3
NCT00590785 COMPLETED
High Risk; Breast Cancer; Positive Nodes; Cyclophosphamide; Doxorubicin
National Cancer Institute (NCI)
 1996-08-13 PHASE3
NCT00676533 COMPLETED
Urinary Tract Infection
Bayer
 2003-06 PHASE4
NCT00438269 COMPLETED
Nosocomial Infection; Pneumonia; Systemic Inflammatory Response Syndrome; Critical Illness; Pyrexia
Canadian Critical Care Trials Group
 2003-02 PHASE2
NCT00257036 COMPLETED
Skin Diseases, Infectious; Cellulitis
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
 1991-07 PHASE2; PHASE3
NCT00392275 COMPLETED
Cataract
Indiana University
 2002-11 PHASE4
NCT00138411 COMPLETED
Bacillus Anthracis (Anthrax)
National Institute of Allergy and Infectious Diseases (NIAID)
 2005-10 PHASE1
NCT00142272 COMPLETED
Cholera
International Centre for Diarrhoeal Disease Research, Bangladesh
 2001-05 PHASE3
NCT00229944 COMPLETED
Cholera
International Centre for Diarrhoeal Disease Research, Bangladesh
 2002-12 PHASE3
NCT00367913 COMPLETED
Pulmonary Diseases
British Thoracic Society
 1995-03 PHASE4
NCT00670215 COMPLETED
Bacterial Infections
Bayer
 2004-04 PHASE3
NCT00258089 COMPLETED
Urinary Tract Infections; Bacteriuria; Urologic Diseases; Pyelonephritis; Neurogenic Bladder
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
 1993-06 PHASE3
NCT00760032 WITHDRAWN
Cirrhosis; Ascites; Infections
Florencia Vargas-Vorackova
 PHASE4
NCT00663806 COMPLETED
Urinary Tract Infections
Bayer
 2003-02 PHASE4
NCT00153634 COMPLETED
Cystic Fibrosis; Chronic Bronchitis
Seattle Children's Hospital
 2004-03
NCT00668122 COMPLETED
Urinary Tract Infection
Bayer
 2004-03 PHASE3
NCT00669994 COMPLETED
Urinary Tract Infection
Bayer
 2003-07 PHASE4
NCT00236808 COMPLETED
Prostatitis
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
 2000-05 PHASE3
NCT00210886 COMPLETED
Urinary Tract Infections; Pyelonephritis
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
 2004-10 PHASE3
NCT00481689 COMPLETED
Urinary Tract Infections
Bayer
 2004-05 PHASE4
NCT00257062 COMPLETED
Skin Diseases, Infectious
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
 1993-01 PHASE3
NCT00126698 COMPLETED
Urinary Tract Infection; Bacteriuria
St. Antonius Hospital
 2005-01 PHASE4
NCT00004216 COMPLETED
Unspecified Adult Solid Tumor, Protocol Specific
Vion Pharmaceuticals
 1999-08 PHASE1
NCT00000641 COMPLETED
Mycobacterium Avium-intracellulare Infection; HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
 PHASE2

(data from https://clinicaltrials.gov, updated on 2026-08-18)

Check the Ciprofloxacin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Ciprofloxacin is a fluoroquinolone antibiotic that binds to and inhibits bacterial DNA gyrase and topoisomerase IV, thereby blocking DNA unwinding and replication to induce fatal double-stranded DNA breakdown. This potent bactericidal activity prevents microbial proliferation and underpins its therapeutic efficacy against diverse bacterial conditions, including urinary tract infections, acute otitis externa, and Neisseria gonorrhoeae infections.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.