CAS No. 298-57-7
Batch:
Purity:99.96
Chemical Structure
Check the
Cinnarizine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 1-benzhydryl-4-[(E)-3-phenylprop-2-enyl]piperazine | |
|---|---|---|
| CAS Number | 298-57-7 | |
| Molecular Formula |
C26H28N2 |
|
| Molecular Weight (MW) | 368.51 | |
| SMILES | C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=CC=C4 | |
| InChIKey | DERZBLKQOCDDDZ-JLHYYAGUSA-N |
Biological Activity
Cinnarizine is a piperazine derivative that acts as a histamine H1 receptor antagonist and calcium channel blocker. By selectively inhibiting histamine H1 receptors and blocking transmembrane calcium influx into vascular smooth muscle cells, cinnarizine suppresses intracellular calcium signaling pathways. This inhibition leads to reduced smooth muscle contractility and attenuated cellular excitability, resulting in significant vasodilation and decreased vascular tone. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
9.1 mg/mL
(24.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
Jump to
Note: Technical data last updated: Sep 1, 2026.