CAS No. 149394-66-1
Batch:
Purity:99.87
Chemical Structure
Check the
Cidofovir hydrate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [(2S)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethylphosphonic acid;dihydrate | |
|---|---|---|
| CAS Number | 149394-66-1 | |
| Molecular Formula |
C8H14N3O6P.2H2O |
|
| Molecular Weight (MW) | 315.22 | |
| SMILES | O.O.NC1=NC(=O)N(CC(CO)OC[P;v5](O)(O)=O)C=C1 | |
| InChIKey | FPKARFMSZDBYQF-ILKKLZGPSA-N |
Cidofovir hydrate is an acyclic nucleoside phosphonate antiviral agent that acts as a selective inhibitor of viral DNA polymerase. Metabolized intracellularly to cidofovir diphosphate, it incorporates into nascent viral DNA strands and inhibits 3′-to-5′ proofreading exonuclease activity. Furthermore, incorporation of cidofovir diphosphate induces nonobligate chain termination and direct polymerase inhibition, thereby blocking viral genomic DNA synthesis. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 4 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.