Cholesterol Clinical Trials

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Clinical Trials

Numerous clinical trials spanning Early Phase 1 through Phase 4 investigate cholesterol and related metabolic management strategies for conditions such as hypercholesterolemia, dyslipidemia, atherosclerosis, cardiovascular disease, chronic obstructive pulmonary disease, and HIV-1. Sponsored by academic medical centers, non-profit entities, and major pharmaceutical companies including Merck Sharp & Dohme LLC and Organon and Co., these studies maintain recruitment statuses ranging from completed to active and upcoming. Evaluated interventions across the portfolio encompass lipid-lowering therapies alongside dietary and mechanical approaches.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07470723	RECRUITING	Heterozygous Familial Hypercholesterolemia (HeFH); Homozygous Familial Hypercholesterolemia (HoFH); Familial Hypercholesterolemia	University of Wisconsin, Madison	2026-02-14
NCT07178444	NOT_YET_RECRUITING	Acute Coronary Syndromes (ACS); Acute Coronary Syndromes	Assistance Publique - Hôpitaux de Paris	2025-11
NCT07515573	NOT_YET_RECRUITING	Dyslipidemia	U.G.A. Nutraceuticals	2026-05-04
NCT06597019	RECRUITING	Familial Hypercholesterolemia - Heterozygous	Novartis Pharmaceuticals	2024-12-09	PHASE3
NCT06597006	RECRUITING	Familial Hypercholesterolemia - Homozygous	Novartis Pharmaceuticals	2025-02-28	PHASE3
NCT05488431	RECRUITING	Dyslipidemias; Cardiovascular Diseases; HIV Infections; Atherosclerosis	Priscilla Hsue, MD	2023-03-01	PHASE2
NCT06437574	RECRUITING	Prostate Cancer	Cedars-Sinai Medical Center	2024-07-16	PHASE2
NCT07441317	NOT_YET_RECRUITING	Primary Hypercholesterolemia or Mixed Hyperlipidemia	Qilu Pharmaceutical Co., Ltd.	2026-03	PHASE3
NCT07028749	RECRUITING	Hypertriglyceridemia	Marea Therapeutics	2025-06-30	PHASE2
NCT07685639	NOT_YET_RECRUITING	ACS (Acute Coronary Syndrome); Hyperlipidemia; Dyslipidemia; Low-Density-Lipoprotein-cholesterol Level	University of Alberta	2026-08
NCT05641753	RECRUITING	Type 1 Diabetes	NYU Langone Health	2022-12-06	PHASE4
NCT04485871	RECRUITING	Type 2 Diabetes; Inflammation; Insulin Sensitivity/Resistance; Fatty Acids, Omega-3	Institut de Recherches Cliniques de Montreal	2019-12-19
NCT07619118	NOT_YET_RECRUITING	Hypercholesterolaemia	AstraZeneca	2026-09-15	PHASE3
NCT05693701	RECRUITING	Lipid Metabolism Disorder	University of Texas Southwestern Medical Center	2023-02-27
NCT05750667	ENROLLING_BY_INVITATION	Familial Hypercholesterolemia	Northwestern University	2023-01-24
NCT06222632	ENROLLING_BY_INVITATION	Elevated LDL Cholesterol	Tung Wah College	2024-03-01
NCT06364163	ACTIVE_NOT_RECRUITING	High Cholesterol	University of Bergen	2024-08-12
NCT07477704	RECRUITING	Hypercholesterolemia	Regeneron Pharmaceuticals	2026-06-17	PHASE2
NCT07626281	RECRUITING	Inclisiran Formulation	Novartis Pharmaceuticals	2026-06-09	PHASE1
NCT04532489	RECRUITING	Radiotracer; Hypertension; Cholesterol	Benjamin Viglianti	2021-01-18	EARLY_PHASE1
NCT07351175	RECRUITING	Cholesterol, Elevated	Anisha Wijeyesekera	2026-01-26
NCT07218900	ACTIVE_NOT_RECRUITING	Dyslipidaemia	AstraZeneca	2025-11-13	PHASE2
NCT05765370	RECRUITING	Atherosclerotic Cardiovascular Disease; Older Patients; LDL Cholesterol	China National Center for Cardiovascular Diseases	2023-03-24
NCT07142317	NOT_YET_RECRUITING	Healthy Participants	Maastricht University Medical Center	2025-10
NCT07199309	RECRUITING	Hypertriglyceridemia	Marea Therapeutics	2025-09-26	PHASE2
NCT06833944	NOT_YET_RECRUITING	Familiar Hypercholesterolemia	Fundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental	2025-02-15
NCT05988866	COMPLETED	Hypercholesterolemia; Dyslipidemias	Gaia AG	2025-02-03
NCT06422741	RECRUITING	Cardiovascular Diseases; Circadian Rhythm Sleep Disorder, Shift Work Type; Cholesterol Level, High	Fundació Eurecat	2024-10-28
NCT07074236	NOT_YET_RECRUITING	Primary Hypercholesterolemia or Combined Hyperlipidemia Characterized by Elevated LDL-C	Qilu Pharmaceutical Co., Ltd.	2025-07	PHASE1
NCT05874141	COMPLETED	Type 2 Diabetes	New Valley University	2023-11-15
NCT03989167	RECRUITING	Hypercholesterolemia, Familial; Clinical Decision Support	University Hospital, Linkoeping	2022-12-06
NCT06431763	COMPLETED	Hypercholesterolemia	Novartis Pharmaceuticals	2024-06-21	PHASE4
NCT06140095	UNKNOWN	Acute Metabolic Effects of Evolocumab and Atorvastatin	Region Stockholm	2024-02	EARLY_PHASE1
NCT01037387	Recruiting	Chronic Obstructive Pulmonary Disease\|Hypercapnic	Hospital Universitario La Paz	2025-12	Phase 4
NCT06096909	NOT_YET_RECRUITING	Acute Coronary Syndrome; Non ST Segment Elevation Acute Coronary Syndrome	China National Center for Cardiovascular Diseases	2023-11-01
NCT06894251	RECRUITING	Healthy Volunteer	Institut Pasteur de Lille	2025-03-10
NCT05694260	COMPLETED	Hypercholesterolemia	Esperion Therapeutics, Inc.	2023-01-12	PHASE2
NCT07295418	COMPLETED	Hyperlipidemias	Shenzhen Salubris Pharmaceuticals Co., Ltd.	2023-10-23	PHASE3
NCT06692764	COMPLETED	Atherosclerotic Cardiovascular Disease	AstraZeneca	2024-10-30	PHASE2
NCT05912296	COMPLETED	Hyperlipemia	Suzhou Ribo Life Science Co. Ltd.	2023-05-30	PHASE1
NCT06567951	UNKNOWN	Pregnancy Related; Hypercholesterolemia	Universidad de los Andes, Chile	2024-09-10
NCT06662695	COMPLETED	Healthy	Shahid Beheshti University of Medical Sciences	2024-11-03
NCT06376201	UNKNOWN	Invasive Fungal Disease	Nanfang Hospital, Southern Medical University	2024-04	PHASE4
NCT05901246	COMPLETED	Cardiovascular Diseases; Hypercholesterolemia; Atherosclerosis	University of Valencia	2023-10-19
NCT06621589	COMPLETED	Obesity	RS H Adam Malik	2024-08-26
NCT01782027	TERMINATED	Cholesterol, HDL; Lipid Metabolism, Inborn Errors; Tangier Disease; LCAT Deficiency; Cholesteryl Ester Transfer Protein (CETP) Deficiency	University of Pennsylvania	2012-10
NCT06159543	Not yet recruiting	Hyperglycemia\|Dyslipidemias\|Insulin Resistance\|Inflammation\|Oxidative Stress	Loma Linda University\|National Mango Board	2024-09	Not Applicable
NCT06405880	Not yet recruiting	Cardiovascular Risk Factors\|Blood Pressure\|Cardiovascular Disease\|Diabetes\|Dyslipidemia	University of Alberta	2024-09	Not Applicable
NCT03393884	ACTIVE_NOT_RECRUITING	Epithelial Ovarian Cancer; Fallopian Tube Cancer; Primary Peritoneal Cancer	Imunon	2018-09-05	PHASE1; PHASE2
NCT05181553	COMPLETED	Familial Hypercholesterolemia; Nutrition, Healthy; Cholesterol, Elevated; Cholesterol; Metabolic Disorder; Cardiovascular Diseases	Laval University	2022-01-10
NCT06448234	COMPLETED	Hypercholesterolemia	S.LAB (SOLOWAYS)	2024-02-02
NCT05888103	COMPLETED	Primary Hypercholesterolemia or Mixed Dyslipidemia	Novartis Pharmaceuticals	2023-07-11	PHASE3
NCT05905068	COMPLETED	To Reduce the LDL-C Level in Hypercholesteremia Adult Patients; Combination for Subgroup High LDL-c Patients With Other Comorbidities	Ikaria Bioscience Pty Ltd	2023-07-14	PHASE1
NCT07564726	COMPLETED	Hypertension; Hypercholesterolemia	Celltrion Pharm, Inc.	2022-08-05	PHASE3
NCT06250673	COMPLETED	Acne Cystic; Diet, Healthy	Igdir University	2023-11-01
NCT04652726	COMPLETED	Familial Hypercholesterolemia - Heterozygous	Novartis Pharmaceuticals	2021-01-27	PHASE3
NCT04659863	COMPLETED	Familial Hypercholesterolemia - Homozygous	Novartis Pharmaceuticals	2021-02-16	PHASE3
NCT06786598	COMPLETED	Breast Cancer	Latakia University	2023-01-01
NCT03967990	COMPLETED	Gut Microbiome; Cholesterol, LDL; Cholesterol, HDL	Arizona State University	2018-03-20
NCT07231367	COMPLETED	Hypercholesterolemia	University of Faisalabad	2023-07-05
NCT05267522	COMPLETED	Hypercholesterolemia; Hyperlipidemias; Physical Inactivity; Diet, Healthy	University of South Australia	2022-03-01
NCT05839236	UNKNOWN	COVID-19 Stress Syndrome; COVID-19 Vaccine Adverse Reaction; COVID-19-Associated Thromboembolism; COVID-19 Post-Intensive Care Syndrome; COVID-19-Associated Stroke; COVID-19 Respiratory Infection	Yang I. Pachankis	2023-05-01	PHASE1
NCT05263778	UNKNOWN	Cardiovascular Diseases; NSTEMI; STEMI	Kaiser Permanente	2022-03	PHASE4
NCT03734211	COMPLETED	Cardiac Allograft Vasculopathy	Lars Gullestad	2019-06-10	PHASE3
NCT04646382	COMPLETED	Cardiovascular Health	DOMCA S.A.	2021-02-01
NCT05267301	COMPLETED	Cholesterol; Triglycerides; Omega-3; Eicosapentaenoic Acid	Qualitas Health	2022-05-11	PHASE4
NCT02816099	COMPLETED	diabète de Type 1	Centre Hospitalier Universitaire Dijon	2014-11-20
NCT05858372	COMPLETED	Hyperlipidemias; Hypercholesterolemia	AHEPA University Hospital	2022-07-01
NCT05038436	COMPLETED	Cholesterol Lowering	Certmedica International GmbH	2021-09-16
NCT04765657	ACTIVE_NOT_RECRUITING	Hypercholesterolemia	Novartis Pharmaceuticals	2021-03-01	PHASE3
NCT06002893	COMPLETED	Hyperlipidemia	Liaquat University of Medical & Health Sciences	2020-03-19
NCT04073134	TERMINATED	Coronary Artery Disease; Atherosclerosis; Hyperlipidemias	Imperial College London	2019-09-11	PHASE4
NCT02354079	ACTIVE_NOT_RECRUITING	Hypobetalipoproteinemia	Nantes University Hospital	2016-01-07
NCT04147767	UNKNOWN	Hypercholesterolemia; Breast Cancer; Obesity	University of Leeds	2020-02-10
NCT04783714	COMPLETED	Hypercholesterolemia	Swisse Wellness Pty Ltd	2021-04-30
NCT04833595	UNKNOWN	Cholesterol; Lipidosis	Monash University Malaysia	2021-03-29
NCT04223557	COMPLETED	Visceral Obesity; Ultrasound Therapy; Dyslipidemias	The First Affiliated Hospital with Nanjing Medical University	2020-05-30
NCT02796378	UNKNOWN	Cardiovascular Disease; Diabetes Mellitus	University of Copenhagen	2016-06	PHASE4
NCT03718286	COMPLETED	ST Elevation Myocardial Infarction; Acute Coronary Syndrome; Hypercholesterolemia; Hyperlipidemias; Dyslipidemias; Physiological Effects of Drugs	Population Health Research Institute	2019-03-11	PHASE2
NCT04974853	COMPLETED	Hypercholesterolemia	NMP Medical Research Institute	2021-06-01
NCT04397055	COMPLETED	Hypercholesterolemia	University of Georgia	2018-05-14
NCT04749784	UNKNOWN	Blood Cholesterol Lowers; LDL-C	Perrigo CSCI	2020-10-30
NCT04529174	COMPLETED	HDL	Metagenics, Inc.	2020-08-18
NCT04359823	COMPLETED	Actinic Porokeratosis	Medical University of South Carolina	2020-08-24	PHASE1
NCT02912793	COMPLETED	Niemann-Pick Disease, Type C1	Cyclo Therapeutics, Inc.	2017-03-20	PHASE1; PHASE2
NCT03540108	COMPLETED	Hypercholesterolemia	University of Roehampton	2020-02-01
NCT02941016	WITHDRAWN	Lipid Lowering, Vascular Inflammation	Rigshospitalet, Denmark	2016-10	PHASE4
NCT03756779	WITHDRAWN	Familial Hypercholesterolemia	University of Texas Southwestern Medical Center	2017-05-15
NCT03590496	COMPLETED	Hypercholesterolemia	Charite University, Berlin, Germany	2018-07-25
NCT03433755	TERMINATED	Primary Hypercholesterolemia; Mixed Dyslipidemia	Amgen	2019-05-09	PHASE3
NCT02770313	COMPLETED	Intermittent Fasting	Intermountain Health Care, Inc.	2016-10
NCT03510715	COMPLETED	Hypercholesterolemia	Sanofi	2018-08-31	PHASE3
NCT03331666	TERMINATED	Familial Hypercholesterolemia	Columbia University	2018-11-16	PHASE4
NCT03729141	WITHDRAWN	Cholesterol	Wake Forest University Health Sciences	2019-10
NCT03355027	UNKNOWN	Atherosclerosis; Cardiovascular Diseases	Cambridge University Hospitals NHS Foundation Trust	2017-11-30
NCT03399370	COMPLETED	ASCVD; Elevated Cholesterol	The Medicines Company	2017-12-21	PHASE3
NCT03400800	COMPLETED	ASCVD; Risk Factor, Cardiovascular; Elevated Cholesterol	The Medicines Company	2017-11-01	PHASE3
NCT04029818	COMPLETED	Cardiovascular Diseases; LDL-cholesterol	Biosearch S.A.	2019-05-24	PHASE1
NCT04841460	COMPLETED	Cholesterol, LDL; Cholesterol, HDL; Research Subjects	Texas A&M University	2019-02-18
NCT03531905	COMPLETED	Diabetes; Diabetes Mellitus, Type 2; Cholesterolemia	Esperion Therapeutics, Inc.	2018-05-09	PHASE2
NCT03805776	UNKNOWN	Intermittent Fasting; Dyslipidemias; HDL Cholesterol, Low Serum; Hepatic Enzymes and Function Abnormalities; Anemia; Kidney Diseases; Cardiac Function	Aga Khan University	2019-02-20
NCT03378999	COMPLETED	Cholesterol Metabolism	Maastricht University Medical Center	2018-06-14
NCT03479983	UNKNOWN	Hypercholesterolemia	Arjuna Natural Limited	2018-06-04
NCT03528252	COMPLETED	Cholesterol, LDL	Uppsala University	2018-05-16
NCT02772640	COMPLETED	Hypercholesterolemia	Collegium Medicum w Bydgoszczy	2016-03	PHASE4
NCT04186780	COMPLETED	Dyslipidemias	University of Sorocaba	2018-09-26
NCT02734706	COMPLETED	Hypercholesterolemia	UAS Labs LLC	2016-03
NCT02719028	COMPLETED	Hyperlipidemias	Golden Biotechnology Corporation	2016-05	PHASE2
NCT03450395	COMPLETED	Microbiome; Plasma Cholesterol; Prebiotic	PepsiCo Global R&D	2018-01-28
NCT03014830	COMPLETED	Atherosclerosis; Coronary Heart Disease	Washington University School of Medicine	2017-06-01	PHASE1
NCT01624142	COMPLETED	Severe Familial Hypercholesterolemia	Amgen	2012-06-01	PHASE2; PHASE3
NCT02589769	COMPLETED	Cardiovascular Disease; Dietary Modification; Cardiovascular Risk Factors	Oslo University Hospital	2016-09
NCT02871362	COMPLETED	Blood Pressure; Low Density Lipoprotein Cholesterol Level	InQpharm Group	2017-03-17
NCT02330406	COMPLETED	Dipeptidyl-Peptidase 4 Inhibitors; LDL Cholesterol; Glycosylated Hemoglobin; Diabetes Mellitus; Coronary Disease	Institute for Clinical Effectiveness, Japan	2015-04	PHASE4
NCT03277079	UNKNOWN	Coronary Artery Disease	University of Roma La Sapienza	2017-10-01	PHASE4
NCT02748057	COMPLETED	Hypercholesterolemia; Familial Hypercholesterolemia	Organon and Co	2016-05-18	PHASE3
NCT01972477	WITHDRAWN	Diabetic Patients; Low HDL-cholesterol (< 35 mg/dL); Lifestyle Intervention for at Least 1 Month	Dexa Medica Group	2016-07	PHASE2; PHASE3
NCT02634580	COMPLETED	Hypercholesterolemia	Amgen	2016-02-27	PHASE3
NCT02612090	COMPLETED	Hypercholesterolemia; Glycemic Response	Clinical Nutrition Research Center, Illinois Institute of Technology	2016-01-04
NCT05750602	COMPLETED	Hypercholesterolemia	Lescuyer Laboratory	2013-11
NCT02492685	WITHDRAWN	Gallbladder Polyp	Yonsei University	2015-07
NCT02480374	COMPLETED	Epithelial Ovarian Cancer; Fallopian Tube Cancer; Primary Peritoneal Cancer	Imunon	2015-09	PHASE1
NCT03425630	COMPLETED	Hypercholesterolemia	Ispharm srl	2016-07
NCT07519967	COMPLETED	Cholesterol; Hypercholesterolaemia	University College Cork	2016-05-30
NCT01528709	COMPLETED	Saphenous Vein Graft Disease	Boca Raton Regional Hospital	2012-03	PHASE3
NCT02847741	UNKNOWN	Current Major Depressive Disorder	University Hospital, Montpellier	2012-06
NCT02593487	UNKNOWN	Hyperlipemia; Coronary Heart Disease	Daping Hospital and the Research Institute of Surgery of the Third Military Medical University	2015-11	PHASE4
NCT02255682	COMPLETED	Cardiovascular Disease; Diabetes Mellitus	University of Copenhagen	2015-01	PHASE4
NCT01764633	COMPLETED	Dyslipidemia	Amgen	2013-02-08	PHASE3
NCT01911390	COMPLETED	Hyperlipidemias	Poudre Valley Health System	2013-07
NCT02532218	UNKNOWN	Hyperlipidemia	Arisaph Pharmaceuticals Inc	2015-08	PHASE2
NCT02327039	COMPLETED	Type 2 Diabetes	University of Padova	2015-03	PHASE4
NCT02508896	COMPLETED	Hypercholesterolemia	Affiris AG	2015-07	PHASE1
NCT02089035	COMPLETED	Hypercholesterolemia	University of Reading	2014-05
NCT02644109	COMPLETED	Dyslipidemias; Hypercholesterolemia	University of Chile	2015-10	PHASE4
NCT02142569	WITHDRAWN	Cholesterol Lowering	University of California, Los Angeles	2013-10-30	PHASE2; PHASE3
NCT01661543	COMPLETED	Hypercholesterolemia	University of Alberta	2013-01
NCT01807078	UNKNOWN	Coronary Artery Disease	University of Roma La Sapienza	2014-01	PHASE4
NCT02185963	COMPLETED	Diabetes	Seoul National University Bundang Hospital	2014-10	PHASE4
NCT02077257	UNKNOWN	Acute Coronary Syndrome	Committee of Cardio-Cerebral-Vascular Diseases of GSC	2014-03	PHASE4
NCT02497235	COMPLETED	Epilepsy, Molecular Mechanisms of Pharmalogical Action, Protective Agents	Takeda	2015-07	PHASE1
NCT03109067	COMPLETED	Healthy Volunteers	Institut National de la Santé Et de la Recherche Médicale, France	2011-09-21
NCT02549144	COMPLETED	Lipids	Azienda Ospedaliero, Universitaria Pisana	2015-01-01
NCT01821131	UNKNOWN	Above Optimal Plasma LDL Concentrations	St. Boniface Hospital	2014-01
NCT00999453	COMPLETED	Hypercholesterolemia	Clinical Research Center for End Stage Renal Disease, Korea	2009-10
NCT02325492	TERMINATED	Gallstones	Galmed Pharmaceuticals Ltd	2014-10	PHASE2
NCT01452100	TERMINATED	Cholesterol Embolism Systemic	University Hospital, Toulouse	2011-06	PHASE2
NCT05734170	COMPLETED	Diet; Habits	Edward Via Virginia College of Osteopathic Medicine	2015-07-28
NCT02198703	COMPLETED	Moderate Hypercholesterolemia	AB Biotics, SA	2014-09
NCT02779673	COMPLETED	LDL-cholesterol Level 130-159mg/dL	Yonsei University	2014-07
NCT01849068	COMPLETED	Metabolic Syndrome X	Laval University	2013-06	PHASE3
NCT02492464	COMPLETED	Atherosclerosis	University of Bologna	2015-05
NCT03263104	COMPLETED	Healthy	University of Roehampton	2015-01
NCT01744977	COMPLETED	Hypercholesterolemia	Durham VA Medical Center	2012-12
NCT02314442	COMPLETED	Hypercholesterolemia	Alnylam Pharmaceuticals	2014-12	PHASE1
NCT01958216	UNKNOWN	Occlusion of Bile Duct With an External Bile Diversion.	Nantes University Hospital	2013-09
NCT02055976	COMPLETED	Hypercholesterolemia	Pfizer	2014-03	PHASE2
NCT00986999	TERMINATED	HIV Infections; Cardiovascular Disease	University of Hawaii	2009-09	PHASE2; PHASE3
NCT01489371	COMPLETED	Ovarian Clear Cell Cystadenocarcinoma; Ovarian Endometrioid Adenocarcinoma; Ovarian Seromucinous Carcinoma; Ovarian Serous Cystadenocarcinoma; Ovarian Undifferentiated Carcinoma; Recurrent Fallopian Tube Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma	Gynecologic Oncology Group	2012-07-09	PHASE1
NCT02475018	COMPLETED	Hypercholesterolemia	Inner Mongolia Yili Industrial Group Co., Ltd	2014-07
NCT00663234	TERMINATED	HIV Infections; Hyperlipidemia	International Maternal Pediatric Adolescent AIDS Clinical Trials Group	2009-08	PHASE1; PHASE2
NCT02221297	COMPLETED	Hypercholesterolemia; Hyperlipidemias; Dyslipidemias	Raisio Group	2014-05
NCT02023879	COMPLETED	Hypercholesterolemia	Sanofi	2013-12-16	PHASE3
NCT03563547	COMPLETED	Heterozygous Familial Hypercholesterolemia	Austrian Academic Institute for Clinical Nutrition	2009-09-03
NCT01941836	COMPLETED	Hypercholesterolemia	Esperion Therapeutics, Inc.	2013-09	PHASE2
NCT01562171	COMPLETED	Obesity; Hypercholesterolemia	University of Manitoba	2012-03
NCT01935674	COMPLETED	HIV; Hypercholesterolaemia	Juan A. Arnaiz	2013-09	PHASE4
NCT02069106	WITHDRAWN	Mixed Hyperlipoproteinemia	Nordic Pharma, USA	2014-02	PHASE4
NCT02259153	COMPLETED	Lipid Metabolism Disorders; Sterols; Diet, High-Fat; Cholesterol; Fatty Acids; Hyperlipidemias	Instituto Aragones de Ciencias de la Salud	2014-03
NCT01890967	COMPLETED	Hypercholesterolemia	Eli Lilly and Company	2013-06	PHASE2
NCT01043380	COMPLETED	Hypercholesterolemia; Coronary Artery Disease	Kumamoto University	2010-01	PHASE4
NCT01930149	COMPLETED	Cardiovascular Diseases; Lipid Testing; Primary Prevention of Cardiovascular Disease	Northwestern University	2013-12
NCT02038387	UNKNOWN	Chronic Hepatitis C Virus; Non Alcoholic Fatty Liver Disease	University of Roma La Sapienza	2012-07
NCT01227330	COMPLETED	Hypercholesterolemia; Medication Adherence	University of Missouri-Columbia	2010-10	PHASE1; PHASE2
NCT01720537	COMPLETED	Hypercholesterolemia	Pfizer	2012-07	PHASE1
NCT01426438	COMPLETED	HIV-1 Infection	Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections	2011-11	PHASE2
NCT01849497	COMPLETED	Primary Hypercholesterolemia; Mixed Dyslipidemia	Amgen	2013-04-18	PHASE3
NCT01825668	UNKNOWN	Hypercholesterolemia; CVD	University of Manitoba	2013-03
NCT01547585	COMPLETED	Hypercholesterolemia; Cardiovascular Disease; CRP	Guelph Food Research Centre	2012-05
NCT02331043	COMPLETED	Dyslipidemias; Hypercholesterolemia; Hyperlipidemias	Raisio Group	2013-03
NCT00879710	COMPLETED	Type 1 Diabetes Mellitus; Type 2 Diabetes Mellitus; Hypercholesterolemia	Medical College of Wisconsin	2008-08
NCT01890031	COMPLETED	Low Risk (0-10% Chance) of Developing Cardiovascular Disease Within 10 Years Based on Risk Factors; Moderate Risk (10-20% Chance) of Developing Cardiovascular (Heart) Disease Within 10 Years Based on Risk Factors	University of Rochester	2012-01	PHASE1
NCT01581372	COMPLETED	Dyslipidemias	University of Alberta	2011-12
NCT01364961	COMPLETED	Dyslipidemia	Maastricht University Medical Center	2011-01
NCT01154036	COMPLETED	Hypercholesterolemia	Organon and Co	2010-07	PHASE3
NCT01043354	COMPLETED	Hypercholesterolemia	Narrows Institute for Biomedical Research	2008-09
NCT01375751	COMPLETED	Hypercholesterolemia, Familial	Amgen	2011-08-02	PHASE2
NCT01375764	COMPLETED	Hyperlipidemia	Amgen	2011-07-28	PHASE2
NCT01566305	COMPLETED	Hypercholesterolemia; Buttermilk; Dietary Modification; Cardiovascular Disease	Maastricht University Medical Center	2010-10
NCT01370603	COMPLETED	Hypercholesterolemia	Organon and Co	2011-09	PHASE3
NCT01380730	COMPLETED	Hyperlipidemia	Amgen	2011-07-01	PHASE2
NCT01350141	COMPLETED	Hypercholesterolemia; Dyslipidemia	Pfizer	2011-06	PHASE2
NCT01362218	TERMINATED	Elevated LDL Cholesterol	Ferrer Internacional S.A.	2010-10	PHASE2
NCT01375777	COMPLETED	Hyperlipidemia	Amgen	2011-07-06	PHASE2
NCT01267227	COMPLETED	Hyperlipidemia; Blood Pressure; Oxidative Stress	University of Mississippi Medical Center	2010-12	PHASE2; PHASE3
NCT01294683	TERMINATED	Primary Hypercholesterolemia; Dyslipidemia	Merck Sharp & Dohme LLC	2011-02-04	PHASE3
NCT01335997	TERMINATED	Primary Hypercholesterolemia; Mixed Dyslipidemia	Merck Sharp & Dohme LLC	2011-05-01	PHASE3
NCT01251991	COMPLETED	Hypercholesterolemia	Aalborg University Hospital	2011-01	PHASE4
NCT01882517	COMPLETED	Hypercholesterolemia; Hyperlipidemias; Dyslipidemias	Raisio Group	2011-03
NCT01354340	COMPLETED	Hypercholesterolaemia	Lescuyer Laboratory	2011-04
NCT01288443	COMPLETED	Hypercholesterolemia	Sanofi	2011-01	PHASE2
NCT01461798	UNKNOWN	Risk Reduction Behavior	Jose María Maya Mejía	2011-10
NCT01139398	COMPLETED	Delivery of Health Care	Lescuyer Laboratory	2010-05
NCT01341613	COMPLETED	Hypercholesterolemia	Micropharma Limited	2011-05	PHASE2
NCT00548145	TERMINATED	Alzheimer Disease; Hypercholesterolemia	Osaka University	2007-11
NCT01262638	COMPLETED	Dyslipidemia	Esperion Therapeutics, Inc.	2010-12	PHASE2
NCT01239004	COMPLETED	Dyslipidemia; Hyperlipidemia; Hyperglycemia	Radiant Research	2010-11	PHASE4
NCT01340456	COMPLETED	CYP3A4 Induction	Karolinska University Hospital	2011-05
NCT01354327	COMPLETED	Hypercholesteremia	Lescuyer Laboratory	2008-12
NCT01716390	COMPLETED	Hypercholesterolemia	Raisio Group	2011-01
NCT00955227	COMPLETED	Hypercholesterolemia; Hyperlipidemia	University of Manitoba	2009-07
NCT01342666	COMPLETED	Hypoalphalipoproteinemia	Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran	2009-03
NCT03988153	COMPLETED	Healthy	Chung Shan Medical University	2010-11-10	PHASE1
NCT01163838	WITHDRAWN	Hypercholesterolemia; Dyslipidemia	Pfizer	2010-08	PHASE1
NCT01799720	COMPLETED	Overweight	Universidad Miguel Hernandez de Elche	2010-10
NCT01163851	COMPLETED	Hypercholesterolemia; Dyslipidemia	Pfizer	2010-07	PHASE1
NCT01454011	COMPLETED	Secondary Hypogonadism	Gulhane School of Medicine	2008-09	PHASE4
NCT01138787	COMPLETED	Cholesterol Absorption Inhibition	Unilever R&D	2010-06
NCT01152073	COMPLETED	Hyperlipidemia	Healthy Drink Discoveries, Inc.	2009-10
NCT00529542	COMPLETED	Polycystic Ovary Syndrome	Milton S. Hershey Medical Center	2004-12	PHASE2
NCT00125593	COMPLETED	Kidney Disease, Chronic	University of Oxford	2003-06	PHASE4
NCT01082562	TERMINATED	Atherosclerosis; Hypercholesterolemia	Bristol-Myers Squibb	2010-04	PHASE1
NCT00746811	COMPLETED	Primary Hypercholesterolemia	Provident Clinical Research	2010-01	PHASE4
NCT01031758	COMPLETED	Healthy	University of Pennsylvania	2009-11
NCT01028274	COMPLETED	LDL Cholesterol; Triglycerides	Nordic Pharma, USA	2009-09	PHASE1; PHASE2
NCT01031862	COMPLETED	Healthy	University of Pennsylvania	2009-11
NCT00688922	UNKNOWN	Acute Myocardial Infarction	Osaka Acute Coronary Insufficiency Study Group	2008-07	PHASE4
NCT00846937	COMPLETED	Ileostoma	University of Helsinki	2009-02
NCT00754741	COMPLETED	Diabetes	Henry Ford Health System	2008-07	PHASE3
NCT00857818	TERMINATED	Schizophrenia; Schizoaffective Disorder; Bipolar I Disorder; Metabolic Syndrome	Otsuka Pharmaceutical Development & Commercialization, Inc.	2009-04	PHASE3
NCT01122355	COMPLETED	Hypertriglyceridemia With Low HDL-cholesterol	Yonsei University	2009-02	PHASE4
NCT00927459	TERMINATED	Hypercholesterolemia	Arbutus Biopharma Corporation	2009-06	PHASE1
NCT00223041	TERMINATED	Renal Transplantation	University Hospital Schleswig-Holstein	2003-04	PHASE2; PHASE3
NCT00615810	COMPLETED	HIV Infections	Gilead Sciences	2008-03	PHASE4
NCT00863265	COMPLETED	Hypercholesterolemia; Coronary Heart Disease	Washington University School of Medicine	2009-06	EARLY_PHASE1
NCT00438425	COMPLETED	Hyperlipidemia; Cardiovascular Disease	University of Toronto	2007-06-25
NCT00772902	COMPLETED	HIV-1	Gilead Sciences	2008-10	PHASE4
NCT00945737	COMPLETED	Hypercholesterolemia	Solae, LLC	2009-04
NCT01061450	COMPLETED	Diastolic Dysfunction; Hypertension	Brasilia Heart Study Group	2006-11	PHASE4
NCT01285544	COMPLETED	Dyslipidemia; Cardiovascular Disease; Hypercholesterolemia	Seoul National University Hospital	2008-09	PHASE4
NCT00653523	COMPLETED	Hypercholesterolemia	Organon and Co	2007-12-01	PHASE3
NCT00812955	COMPLETED	Dyslipidemia, Hypercholesterolemia, Hypertriglyceridemia	AstraZeneca	2008-11	PHASE3
NCT00725829	UNKNOWN	Acute Coronary Syndrome	Jagiellonian University	2008-06
NCT01008345	COMPLETED	Coronary Artery Disease; Diabetes	Hotel Dieu de France Hospital	2008-09	PHASE4
NCT00947635	COMPLETED	Immunosuppression; Hyperlipidemias; Diabetes Mellitus, Type 1	University of Alberta	2005-11	PHASE1; PHASE2
NCT00920894	COMPLETED	Elevated Blood Lipids	Clinical Life Sciences Ltd.	2009-01
NCT01084226	COMPLETED	Hypercholesterol	University of Helsinki	2008-02	PHASE2
NCT00762164	COMPLETED	Hypercholesterolemia	Bronx VA Medical Center	2007-03	PHASE4
NCT00724217	UNKNOWN	Hyperlipidemia	Logan College of Chiropractic	2008-07	PHASE1; PHASE2
NCT00535405	COMPLETED	Hypercholesterolemia	Organon and Co	2007-11	PHASE3
NCT00923403	COMPLETED	Hypercholesterolemia	University of Manitoba	2008-08	PHASE1; PHASE2
NCT01035086	COMPLETED	Hypercholesterolemia	University of Jena	2008-06
NCT00690937	COMPLETED	Hypercholesterolemia	Genzyme, a Sanofi Company	2008-02	PHASE2
NCT00515476	COMPLETED	Metabolic Syndrome X	Hannover Medical School	2007-06
NCT00526058	COMPLETED	Hypercholesterolemia	B. Braun Medical Inc.	2007-08
NCT00677248	COMPLETED	Hypercholesterolemia	Karo Bio AB	2008-04	PHASE2
NCT00291473	COMPLETED	Esophageal Cancer; Lung Cancer; Stomach Cancer; Breast Cancer; Ovarian Cancer	Ludwig Institute for Cancer Research	2005-07	PHASE1
NCT00282659	COMPLETED	Coronary Artery Disease; Hypertension; Dyslipidemia; Diabetes	Hartford Hospital	2006-01	PHASE4
NCT00540293	COMPLETED	Dyslipidemias	Pfizer's Upjohn has merged with Mylan to form Viatris Inc.	2007-10	PHASE4
NCT00124072	COMPLETED	Cardiovascular Disease	University of Oxford	1998-07	PHASE3
NCT00260442	COMPLETED	Sarcopenia; Cardiovascular Disease	Texas A&M University	2005-11
NCT00423579	COMPLETED	Hypercholesterolemia; Coronary Disease	Organon and Co	2006-07-01	PHASE4
NCT00479713	COMPLETED	Hypercholesterolemia	Organon and Co	2007-02-01	PHASE3
NCT00536510	COMPLETED	Hypercholesterolemia; Hyperlipidemia	Merck Sharp & Dohme LLC	2007-04	PHASE3
NCT00276484	COMPLETED	Hypercholesterolemia	Organon and Co	2006-02	PHASE3
NCT00427960	TERMINATED	Hypercholesterolaemia	AstraZeneca	2006-12	PHASE4
NCT00794677	COMPLETED	Hypercholesterolemia	UCSF Benioff Children's Hospital Oakland	2006-06	PHASE4
NCT00276458	COMPLETED	Hypercholesterolemia	Organon and Co	2006-02	PHASE3
NCT00924391	COMPLETED	Coronary Heart Disease	University of Manitoba	2007-09	PHASE2
NCT01036308	COMPLETED	Healthy	University of Jena	2007-07
NCT00145574	COMPLETED	Hypercholesterolemia	Daiichi Sankyo	2005-11	PHASE4
NCT00769132	COMPLETED	Hypercholesterolemia	Merck Sharp & Dohme LLC	2007-08-03	PHASE1
NCT02089867	COMPLETED	Coronary Artery Disease	Jose Rocha Faria Neto	2006-10	PHASE2; PHASE3
NCT00231569	COMPLETED	Hypercholesterolemia	Kastle Therapeutics, LLC	2005-09	PHASE2
NCT00280995	COMPLETED	Hypercholesterolemia, Familial	Kastle Therapeutics, LLC	2006-01	PHASE2
NCT00263081	TERMINATED	Hypercholesterolemia	Takeda	2005-11	PHASE3
NCT00860509	COMPLETED	Hypercholesterolemia; Coronary Heart Disease	Washington University School of Medicine	2006-11
NCT00216463	COMPLETED	Hypercholesterolemia	Kastle Therapeutics, LLC	2005-08	PHASE2
NCT00166530	COMPLETED	Atherosclerosis	Organon and Co	2005-11	PHASE4
NCT00405067	COMPLETED	Hypercholesterolemia	Aegerion Pharmaceuticals, Inc.	2006-05	PHASE2
NCT00267280	TERMINATED	Hyperlipidemia; Dyslipidemia; Hypercholesterolemia	Pfizer	2006-01	PHASE3
NCT00220974	COMPLETED	Hypercholesterolemia	The George Institute	2004-10
NCT00147251	COMPLETED	Cardiovascular Disease; Hypertension; Hyperlipidemia; Diabetes; Carotid Atherosclerosis	Cynthia West	2003-05	PHASE4
NCT00678067	COMPLETED	Hypercholesterolemia	University of Milan	2005-06
NCT00101439	COMPLETED	Hypercholesterolemia	Organon and Co	2005-11-10	PHASE3
NCT00202904	COMPLETED	Hypercholesterolemia; Coronary Heart Disease	Organon and Co	2005-05	PHASE4
NCT00319449	COMPLETED	Hypercholesterolemia; Coronary Arteriosclerosis	Organon and Co	2005-09	PHASE4
NCT00860054	COMPLETED	Hypercholesterolemia; Coronary Heart Disease	Washington University School of Medicine	2006-03
NCT00158899	COMPLETED	Dyslipidaemias; Dyslipidaemia	GlaxoSmithKline	2004-08	PHASE2
NCT00697203	COMPLETED	Dyslipidemia	Hoffmann-La Roche	2005-07	PHASE2
NCT00136799	COMPLETED	Mixed Dyslipidemia; Hypercholesterolemia	Novartis	2005-06	PHASE3
NCT00143663	COMPLETED	Dyslipidemia	Takeda	2005-09	PHASE3
NCT00397826	COMPLETED	Hypercholesterolemia	Cardinal Tien Hospital	2005-01	PHASE4
NCT00171093	COMPLETED	HYPERTENSION; HYPERCHOLESTEROLEMIA	Novartis	2004-09	PHASE3
NCT01571869	COMPLETED	Mildly Hypercholesterolemic Subjects	Danone Global Research & Innovation Center	2005-04
NCT00110435	COMPLETED	Type 2 Diabetes Mellitus; Hypercholesterolemia	Organon and Co	2005-05	PHASE3
NCT01600820	COMPLETED	Hypercholesterolemia	Danone Spain	2005-02
NCT01921010	COMPLETED	Cardiovascular Outcomes	Cedars-Sinai Medical Center	2003-06	PHASE4
NCT00239330	COMPLETED	Hypercholesteremia	AstraZeneca	2003-06	PHASE3
NCT01574469	COMPLETED	Mildly Hypercholesterolemic Subjects	Danone Global Research & Innovation Center	2004-09
NCT00090298	COMPLETED	Hypercholesterolemia	Organon and Co	2004-04	PHASE3
NCT00240266	COMPLETED	Metabolic Syndrome; Dyslipidemia	AstraZeneca	2003-08	PHASE3
NCT00090168	COMPLETED	Hypercholesterolemia; Atherosclerotic Disease; Coronary Disease	Organon and Co	2004-01-27	PHASE3
NCT00092612	COMPLETED	Hypercholesterolemia; Coronary Disease	Organon and Co	2003-05	PHASE3
NCT01882283	COMPLETED	Hypercholesterolemia	University of Minnesota	2002-04
NCT00652301	COMPLETED	Cholesterol	Organon and Co	2003-07	PHASE3
NCT00092586	COMPLETED	Hypercholesterolemia	Organon and Co	2002-09	PHASE3
NCT00651144	COMPLETED	Hypercholesterolemia; Atherosclerosis	Organon and Co	2003-03	PHASE1
NCT00551447	COMPLETED	Coronary Disease	Organon and Co	2002-01	PHASE3
NCT03882996	COMPLETED	Hypercholesterolemia	Organon and Co	2000-10-06	PHASE3
NCT00009841	COMPLETED	Head and Neck Cancer	University of Pittsburgh	1999-03	PHASE1
NCT01422317	COMPLETED	Coronary Disease; Myocardial Infarction	Helse Stavanger HF	1995-09	PHASE3
NCT03741621	COMPLETED	Lipidemia; Healthy	Unity Health Toronto	1992-01	PHASE2
NCT00657527	COMPLETED	Myocardial Ischaemia; Coronary Artery Disease	AstraZeneca	2001-12	PHASE3
NCT00327691	COMPLETED	Cardiovascular Disease; Cerebrovascular Accident; Coronary Heart Disease	Pfizer	1998-04	PHASE4
NCT00518960	UNKNOWN	Metabolic Syndrome; Hyperlipidemia	Health Enhancement Products, Inc.	2007-04
NCT00267254	COMPLETED	Hyperlipidemia; Dyslipidemia; Hypercholesterolemia	Pfizer	2006-01	PHASE3
NCT00457379	UNKNOWN	Coronary Artery Disease	Hannover Medical School	2007-04
NCT00654394	COMPLETED	Carotid Artery Stenosis; Hypercholesterolemia	AstraZeneca	2000-01	PHASE3
NCT00457340	COMPLETED	Arrhythmia	Pfizer's Upjohn has merged with Mylan to form Viatris Inc.	2000-02	PHASE4
NCT00522158	COMPLETED	Type 2 Diabetes Mellitus; Cardiovascular Disease; LDL Cholesterol; Cognition	Baskent University		PHASE4
NCT00051415	COMPLETED	Hypercholesterolemia	National Center for Complementary and Integrative Health (NCCIH)	2003-01	PHASE2; PHASE3
NCT00653965	COMPLETED	Hypercholesterolemia; Dyslipidaemia	AstraZeneca	2003-05	PHASE3
NCT00449410	COMPLETED	Atrial Fibrillation; Neuropsychology; Magnetic Resonance Imaging; Inflammation; Hemostasis	Radboud University Medical Center	2005-05	PHASE4
NCT00258999	COMPLETED	Atherosclerosis	University of Wisconsin, Madison	2005-10
NCT00454831	COMPLETED	Hypercholesterolemia	DNP Canada	2006-02	PHASE2
NCT00288483	TERMINATED	Hypercholesterolemia; Combined Hyperlipidemia	Drug Commission of the German Medical Association	2000-09	PHASE3
NCT00404001	COMPLETED	Hypercholesterolemia	Ironwood Pharmaceuticals, Inc.	2006-11	PHASE2
NCT00106158	COMPLETED	Neoplasms	Ludwig Institute for Cancer Research	2004-06	PHASE1
NCT00136942	COMPLETED	Hyperlipidemia	Pfizer's Upjohn has merged with Mylan to form Viatris Inc.	2005-04	PHASE3
NCT00211705	COMPLETED	Hyperlipidemia	Mitsukoshi Health and Welfare Foundation	1994-02	PHASE4
NCT00057044	COMPLETED	Physicians' Practice Patterns; Coronary Heart Disease	US Department of Veterans Affairs	2001-10
NCT00654407	COMPLETED	Hypercholesterolemia	AstraZeneca	2001-11	PHASE3
NCT00653588	COMPLETED	Hypercholesterolemia; Coronary Heart Disease	AstraZeneca	2003-04	PHASE3
NCT00345722	COMPLETED	Hyperlipidemia; Cardiovascular Diseases; Hypercholesterolemia	University of Toronto	2006-06	PHASE2
NCT00654537	COMPLETED	Hypercholesterolemia	AstraZeneca	2001-04	PHASE3

(data from https://clinicaltrials.gov, updated on 2026-03-13)

Check the Cholesterol product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

As an essential structural sterol, cholesterol integrates into cellular lipid bilayers to modulate membrane fluidity, permeability, and microdomain assembly, including lipid rafts. Disruption of lipid bilayer cholesterol architecture alters downstream receptor-mediated cell signaling cascades and vesicular trafficking, leading to dysregulated cellular lipid handling that contributes to hypercholesterolemia, dyslipidemia, and vascular atherosclerosis.

Appendix RUO and cGMP Quality Standards

Quality Dimension	RUO (Research Use Only)	cGMP (Current Good Manufacturing Practice)
Clinical Applicability	Prohibited in human clinical trials or medical diagnostics.	Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status	Non-regulated grade; exempt from drug manufacturing laws.	Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment	Unclassified analytical or research laboratories.	Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control	Basic purity and activity testing.	Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation	Basic equipment calibration; no process validation required.	Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance	Vendor self-declared without required formal QMS.	Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact	High risk of IND rejection if used as a critical raw material.	Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).