CAS No. 94-20-2
Batch:
Purity:99.85
Chemical Structure
Check the
Chlorpropamide
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 1-(4-chlorophenyl)sulfonyl-3-propylurea | |
|---|---|---|
| CAS Number | 94-20-2 | |
| Molecular Formula |
C10H13ClN2O3S |
|
| Molecular Weight (MW) | 276.74 | |
| SMILES | CCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)Cl | |
| InChIKey | RKWGIWYCVPQPMF-UHFFFAOYSA-N |
Biological Activity
Chlorpropamide is a sulfonylurea class agent that acts as an inhibitor of ATP-sensitive potassium (KATP) channels and Na+/K+-ATPase. By blocking KATP channels in pancreatic beta cells, chlorpropamide induces membrane depolarization, promoting voltage-gated calcium influx and stimulating insulin secretion. Additionally, chlorpropamide modulates intracellular cyclic AMP signaling and hepatic glucose metabolism, contributing to its anti-diabetic activity. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
55 mg/mL
(198.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 55 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.