CAS No. 50-63-5

Batch: Purity:99.97
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Chloroquine diphosphate Chemical Structure
Chemical Structure
Check the Chloroquine diphosphate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 50-63-5
Molecular Formula

C18H26ClN3.2H3O4P
Molecular Weight (MW) 515.86
SMILES CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O

Biological Activity

Chloroquine diphosphate is an antimalarial and antirheumatoid 4-aminoquinoline derivative that acts as an activator of ataxia telangiectasia mutated (ATM) kinase and an inhibitor of toll-like receptor (TLR) signaling. By increasing endosomal pH and inhibiting lysosomal degradation, chloroquine impairs autophagic flux and blocks endosomal TLR activation. Additionally, chloroquine induces ATM autophosphorylation and downstream signaling independently of direct DNA double-strand break induction, modulating cellular stress responses and immune activation. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 100 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Bakkenist CJ, et al. Nature. 2003;421(6922):499-506.

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Note: Technical data last updated: Sep 1, 2026.