CAS No. 34316-15-9
Batch:
Purity:98.81
Chemical Structure
Check the
Chelerythrine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium | |
|---|---|---|
| CAS Number | 34316-15-9 | |
| Molecular Formula |
C21H18NO4 |
|
| Molecular Weight (MW) | 348.37 | |
| SMILES | COC1=C(OC)C2=C[N+](=C3C(=C2C=C1)C=CC4=CC5=C(OCO5)C=C34)C | |
| InChIKey | LLEJIEBFSOEYIV-UHFFFAOYSA-N |
Chelerythrine is a benzophenanthridine alkaloid acting as a potent antagonist of protein kinase C (PKC, IC= and an inhibitor of Bcl-xL–Bak BH3 peptide binding (IC=. By targeting the catalytic domain of PKC, it disrupts cellular phosphorylation signaling to inhibit tumor cell growth. Furthermore, direct inhibition of Bcl-xL promotes mitochondrial cytochrome c release and triggers apoptosis, contributing to its antitumor efficacy. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
2 mg/mL
(5.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.