CAS No. 153504-70-2

Batch: Purity:98.06
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Cevimeline HCl hemihydrate Chemical Structure
Chemical Structure
Check the Cevimeline HCl hemihydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 153504-70-2
Molecular Formula

C10H18ClNOS.1/2H2O
Molecular Weight (MW) 244.78
SMILES CC1OC2(CN3CCC2CC3)CS1.CC1OC2(CN3CCC2CC3)CS1.O.Cl.Cl

Ordering Information

Biological Activity

Cevimeline HCl hemihydrate (AF 102B) is a parasympathomimetic agent that functions as an agonist at muscarinic acetylcholine receptors M1 and M3. Activation of these muscarinic receptor subtypes triggers downstream intracellular calcium mobilization and cholinergic signaling cascades within exocrine tissues. This pathway stimulation facilitates exocrine gland function, markedly increasing salivary and lacrimal secretion.

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 40 mg/mL (163.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 40 mg/mL
Ethanol 40 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.