CAS No. 1380575-43-8
Batch:
Purity:99.88
Chemical Structure
Check the
Ceritinib dihydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1380575-43-8 | |
|---|---|---|
| Molecular Formula |
C28H38Cl3N5O3S |
|
| Molecular Weight (MW) | 631.06 | |
| SMILES | Cl.Cl.CC(C)OC1=C(NC2=NC=C(Cl)C(=N2)NC3=CC=CC=C3[S](=O)(=O)C(C)C)C=C(C)C(=C1)C4CCNCC4 |
Ceritinib dihydrochloride is a selective, ATP-competitive, and orally bioavailable inhibitor of ALK (IC50 =, InsR (IC50 =, IGF-1R (IC50 =, and STK22D (IC50 =. By suppressing ALK kinase activity, it blocks downstream signal transduction through the STAT3, AKT/mTOR, and MAPK pathways, impairing cell proliferation and inducing apoptosis in ALK-dependent cancer cells, demonstrating potent antitumor activity. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
13 mg/mL
(20.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(158.46 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 50 mg/mL |
| Ethanol | 11 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Ceritinib dihydrochloride Clinical Trials
- Ceritinib dihydrochloride Solubility in DMSO
- Ceritinib dihydrochloride Stock Solution
- Ceritinib dihydrochloride Storage
- Ceritinib dihydrochloride Stability
- Ceritinib dihydrochloride Molecular Weight
- Ceritinib dihydrochloride SMILES
- Ceritinib dihydrochloride Chemical Structure (2D and 3D)
- Ceritinib dihydrochloride SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.