Ceralasertib (AZD6738) SDS | MSDS

1.PRODUCT AND COMPANY IDENTIFICATION

Product identifier

Product Name: Ceralasertib (AZD6738)
Catalog Number: S7693
CAS Number: 1352226-88-0
IUPAC Name: 4-[4-[1-[[S(R)]-S-methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridine

Relevant identified uses and uses advised against

Identified uses: For research and development use only; laboratory chemicals; manufacture of substances.
Uses advised against: Not for pharmaceutical, household, or other unapproved uses.

Details of the supplier

Company : Selleck Chemicals
TollFree : +1 877 796-6397
Tel : +1 832 582-8158
Fax : +1 832 582-8590

Emergency telephone number

Emergency phone #: +1 832 582-8158

2. HAZARD IDENTIFICATION

2.1 Classification of the substance or mixture
The substance is classified under the GHS as follows:

Acute toxicity, Oral (Category 4)
Carcinogenicity (Category 2)
Reproductive toxicity (Category 1B)
Specific target organ toxicity – single exposure (Category 1)
Specific target organ toxicity – repeated exposure (Category 1)

2.2 GHS label elements, including precautionary statements
Pictogram: GHS07 , GHS08
Signal word: Danger
Hazard statement(s):

H302: Harmful if swallowed
H351: Suspected of causing cancer
H360: May damage fertility or the unborn child
H370: Causes damage to organs
H372: Causes damage to organs through prolonged or repeated exposure

Precautionary statement(s):

Prevention: P264 Wash thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection. P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Response: P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P318 IF exposed or concerned, get medical advice. P308+P316 IF exposed or concerned: Get emergency medical help immediately. P321 Specific treatment (see on this label). P319 Get medical help if you feel unwell.
Storage: P405 Store locked up.
Disposal: P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

2.3 Other hazards which do not result in classification
No specific data provided for this section.

3. COMPOSITION/INFORMATION ON INGREDIENTS

3.1 Substances

Chemical name: 4-[4-[1-[[S(R)]-S-methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridine
Common names and synonyms: Ceralasertib
CAS number: 1352226-88-0
EC number: No specific data provided for this section.

4. FIRST-AID MEASURES

4.1 Description of necessary first-aid measures

General advice: No specific data provided for this section.
If inhaled: Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth-to-mouth resuscitation if the victim ingested or inhaled the chemical.
Following skin contact: Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.
Following eye contact: Rinse with pure water for at least 15 minutes. Consult a doctor.
Following ingestion: Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

4.2 Most important symptoms/effects, acute and delayed
No specific data provided for this section.

4.3 Indication of immediate medical attention and special treatment needed, if necessary
No specific data provided for this section.

5. FIRE-FIGHTING MEASURES

5.1 Extinguishing media
Use dry chemical, carbon dioxide, or alcohol-resistant foam.

5.2 Specific hazards arising from the chemical
No specific data provided for this section.

5.3 Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.

6. ACCIDENTAL RELEASE MEASURES

6.1 Personal precautions, protective equipment and emergency procedures
Avoid formation of powder. Avoid breathing mist, gas, or vapours. Avoid contact with skin and eyes. Use personal protective equipment. Wear chemical-impermeable gloves. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Keep people away from and upwind of spill/leak.

6.2 Environmental precautions
Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of in accordance with appropriate laws and regulations.

7. HANDLING AND STORAGE

7.1 Precautions for safe handling
Handle in a well-ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of powder and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

7.2 Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool, and well-ventilated place. Store apart from foodstuff containers or incompatible materials. Keep away from moisture. Store at low temperature and under nitrogen.

powder: -20°C for 3 years
In solvent: -80°C for 1 year

8. EXPOSURE CONTROLS/PERSONAL PROTECTION

8.1 Control parameters

Occupational Exposure limit values: No specific data provided for this section.
Biological limit values: No specific data provided for this section.

8.2 Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection: Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).
Skin protection: Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves must satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374.
Respiratory protection: If exposure limits are exceeded or irritation is experienced, use a full-face respirator.
Thermal hazards: No specific data provided for this section.

9. PHYSICAL AND CHEMICAL PROPERTIES

Physical state: powder
Color: White
Odour: No specific data provided for this section.
Melting point/freezing point: No specific data provided for this section.
Boiling point or initial boiling point and boiling range: No specific data provided for this section.
Flammability: No specific data provided for this section.
Lower and upper explosion limit/flammability limit: No specific data provided for this section.
Flash point: No specific data provided for this section.
Auto-ignition temperature: No specific data provided for this section.
Decomposition temperature: No specific data provided for this section.
pH: No specific data provided for this section.
Kinematic viscosity: No specific data provided for this section.
Solubility: H2O: < 1 mg/mL (insoluble or slightly soluble); Ethanol: 39 mg/mL (94.54 mM), Sonication is recommended; DMSO: 250 mg/mL (606.05 mM), Sonication is recommended. (< 1 mg/ml refers to the product slightly soluble or insoluble)
N-octanol-water partition coefficient: No specific data provided for this section.
Vapour pressure: No specific data provided for this section.
Density and/or relative density: 1.52 g/cm3 (Predicted)
Relative vapour density: No specific data provided for this section.
Particle characteristics: No specific data provided for this section.

10. STABILITY AND REACTIVITY

10.1 Reactivity
No specific data provided for this section.

10.2 Chemical stability
No specific data provided for this section.

10.3 Possibility of hazardous reactions
No specific data provided for this section.

10.4 Conditions to avoid
No specific data provided for this section.

10.5 Incompatible materials
No specific data provided for this section.

10.6 Hazardous decomposition products
No specific data provided for this section.

11. TOXICOLOGICAL INFORMATION

Acute toxicity: Oral: no data available; Inhalation: no data available; Dermal: no data available.
Skin corrosion/irritation: No specific data provided for this section.
Serious eye damage/irritation: No specific data provided for this section.
Respiratory or skin sensitization: No specific data provided for this section.
Germ cell mutagenicity: No specific data provided for this section.
Carcinogenicity: No specific data provided for this section.
Reproductive toxicity: No specific data provided for this section.
STOT-single exposure: No specific data provided for this section.
STOT-repeated exposure: No specific data provided for this section.
Aspiration hazard: No specific data provided for this section.

12. ECOLOGICAL INFORMATION

12.1 Toxicity

Toxicity to fish: no data available.
Toxicity to daphnia and other aquatic invertebrates: no data available.
Toxicity to algae: no data available.
Toxicity to microorganisms: no data available.

12.2 Persistence and degradability
No specific data provided for this section.

12.3 Bioaccumulative potential
No specific data provided for this section.

12.4 Mobility in soil
No specific data provided for this section.

12.5 Other adverse effects
No specific data provided for this section.

13. DISPOSAL CONSIDERATIONS

13.1 Disposal methods

Product: The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging: Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14. TRANSPORT INFORMATION

14.1 UN Number
No specific data provided for this section.

14.2 UN Proper Shipping Name
No specific data provided for this section.

14.3 Transport hazard class(es)
No specific data provided for this section.

14.4 Packing group, if applicable
No specific data provided for this section.

14.5 Environmental hazards
No specific data provided for this section.

14.6 Special precautions for user
No specific data provided for this section.

14.7 Transport in bulk according to IMO instruments
No specific data provided for this section.

15. REGULATORY INFORMATION

15.1 Safety, health and environmental regulations specific for the product in question

European Inventory of Existing Commercial Chemical Substances (EINECS): Not Listed.
EC Inventory: Not Listed.
United States Toxic Substances Control Act (TSCA) Inventory: Not Listed.
China Catalog of Hazardous chemicals 2015: Not Listed.
New Zealand Inventory of Chemicals (NZIoC): Not Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS): Not Listed.
Vietnam National Chemical Inventory: Not Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC): Not Listed.
Korea Existing Chemicals List (KECL): Not Listed.

16. OTHER INFORMATION

Revision Date: 2026/07/09
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.