Ceralasertib (AZD6738) is a potent, selective, ATP-competitive ATR inhibitor. It affects DNA damage response and ATR-Chk1 signaling by blocking Chk1 phosphorylation and inducing replication catastrophe, effectively inhibiting tumor cell proliferation and promoting apoptosis.
Ceralasertib (AZD6738) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Ceralasertib (AZD6738) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.