CAS No. 104376-79-6

Batch: Purity:99.06
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Ceftriaxone disodium salt hemi (heptahydrate) Chemical Structure
Chemical Structure
Check the Ceftriaxone disodium salt hemi (heptahydrate) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 104376-79-6
Molecular Formula

C18H16N8O7S3.7/2H2O.2Na
Molecular Weight (MW) 661.6
SMILES CN1C(=NC(=O)C(=O)N1)SCC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)[O-].[Na+]

Ordering Information

Biological Activity

Ceftriaxone disodium salt hemi (heptahydrate) is a third-generation cephalosporin antibiotic that targets penicillin-binding proteins to inhibit bacterial cell wall synthesis. By binding to essential penicillin-binding proteins, ceftriaxone prevents peptidoglycan cross-linking, leading to bacterial cell wall degradation and cell lysis. Additionally, ceftriaxone upregulates glutamate transporter 1 expression, enhancing glutamate clearance and exerting neuroprotective activity in central nervous system disease models. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 100 mg/mL
DMSO 1 mg/mL (1.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.