CAS No. 2323027-38-7
Batch:
Purity:99.94
Chemical Structure
Check the
Ceapin-A7
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]pyrazol-4-yl]-5-(furan-2-yl)-1,2-oxazole-3-carboxamide | |
|---|---|---|
| CAS Number | 2323027-38-7 | |
| Molecular Formula |
C20H12F6N4O3 |
|
| Molecular Weight (MW) | 470.32 | |
| SMILES | FC(F)(F)C1=CC=C(C[N]2C=C(NC(=O)C3=NOC(=C3)C4=CC=CO4)C=N2)C(=C1)C(F)(F)F | |
| InChIKey | UJTDYOXTXGBHEG-UHFFFAOYSA-N |
Biological Activity
Ceapin-Ais a selective inhibitor of activating transcription factor 6α (ATF6α) within the unfolded protein response (UPR) pathway. It blocks ATF6α trafficking from the endoplasmic reticulum to the Golgi apparatus during ER stress, preventing its proteolytic processing and activation. This inhibition suppresses downstream chaperone gene expression and sensitizes cells to ER stress without altering the IRE1 or PERK signaling arms. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(212.62 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 8 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.