CAS No. 346640-08-2
Batch:
Purity:98.18
Chemical Structure
Check the
CCF642
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (5E)-3-(4-methoxyphenyl)-5-[(5-nitrothiophen-2-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one | |
|---|---|---|
| CAS Number | 346640-08-2 | |
| Molecular Formula |
C15H10N2O4S3 |
|
| Molecular Weight (MW) | 378.45 | |
| SMILES | COC1=CC=C(C=C1)N2C(=O)C(=CC3=CC=C(S3)[N+](=O)[O-])SC2=S | |
| InChIKey | SPYIETQLOVDJCF-XYOKQWHBSA-N |
CCF642 is a small-molecule protein disulfide isomerase (PDI) inhibitor exhibiting targeted antimyeloma activity. By suppressing PDI function, this compound disrupts endoplasmic reticulum proteostasis and exacerbates endoplasmic reticulum stress in cancer cells. This loss of protein folding capacity impairs cell viability, activates apoptotic signaling pathways, and effectively reduces multiple myeloma cell proliferation and survival. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
15 mg/mL
(39.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.