CAS No. 555-60-2
| IUPAC Name | 2-[(3-chlorophenyl)hydrazinylidene]propanedinitrile | |
|---|---|---|
| CAS Number | 555-60-2 | |
| Molecular Formula |
C9H5ClN4 |
|
| Molecular Weight (MW) | 204.62 | |
| SMILES | C1=CC(=CC(=C1)Cl)NN=C(C#N)C#N | |
| InChIKey | UGTJLJZQQFGTJD-UHFFFAOYSA-N |
CCCP (Carbonyl cyanide 3-chlorophenylhydrazone) is a potent protonophore mitochondrial uncoupler and oxidative phosphorylation inhibitor. By increasing inner mitochondrial membrane permeability to protons, CCCP rapidly dissipates the mitochondrial membrane potential (MMP). This loss of potential impairs ATP synthesis, triggers PINK1 stabilization on the outer mitochondrial membrane, and recruits Parkin to damaged mitochondria, ultimately driving selective autophagic degradation through the mitophagy pathway. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
41 mg/mL
(200.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 14 mg/mL |
| Water | Insoluble |
| DMSO |
41 mg/mL
(200.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 41 mg/mL |
| Water | Insoluble |
| DMSO |
41 mg/mL
(200.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 20 mg/mL |
| Water | Insoluble |
| DMSO |
40 mg/mL
(195.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 20 mg/mL |
| Water | Insoluble |
| DMSO |
41 mg/mL
(200.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 21 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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- CCCP (Carbonyl cyanide 3-chlorophenylhydrazone) Clinical Trials
- CCCP (Carbonyl cyanide 3-chlorophenylhydrazone) Solubility in DMSO
- CCCP (Carbonyl cyanide 3-chlorophenylhydrazone) Stock Solution
- CCCP (Carbonyl cyanide 3-chlorophenylhydrazone) Storage
- CCCP (Carbonyl cyanide 3-chlorophenylhydrazone) Stability
- CCCP (Carbonyl cyanide 3-chlorophenylhydrazone) Molecular Weight
- CCCP (Carbonyl cyanide 3-chlorophenylhydrazone) SMILES
- CCCP (Carbonyl cyanide 3-chlorophenylhydrazone) Chemical Structure (2D and 3D)
- CCCP (Carbonyl cyanide 3-chlorophenylhydrazone) SDS｜MSDS