CAS No. 681159-27-3
Batch:
Purity:99.81
Chemical Structure
Check the
CBR-5884
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | ethyl 5-(furan-2-carbonylamino)-3-methyl-4-thiocyanatothiophene-2-carboxylate | |
|---|---|---|
| CAS Number | 681159-27-3 | |
| Molecular Formula |
C14H12N2O4S2 |
|
| Molecular Weight (MW) | 336.39 | |
| SMILES | CCOC(=O)C1=C(C(=C(S1)NC(=O)C2=CC=CO2)SC#N)C | |
| InChIKey | QBVIRPJBDIZKBC-UHFFFAOYSA-N |
CBR-5884 is a selective inhibitor of phosphoglycerate dehydrogenase (PHGDH) with an IC50 of. By disrupting the oligomeric state of PHGDH, CBR-5884 effectively suppresses de novo serine biosynthesis from glucose in cancer cells. Downstream, this inhibition selectively blocks cell proliferation and displays target-specific cytotoxicity in human cancer cell lines characterized by high serine biosynthetic pathway activity. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
67 mg/mL
(199.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.