CAS No. 1197397-89-9
Batch:
Purity:99.95
Chemical Structure
Check the
CBL0137 Hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[6-acetyl-9-[2-(propan-2-ylamino)ethyl]carbazol-3-yl]ethanone;hydrochloride | |
|---|---|---|
| CAS Number | 1197397-89-9 | |
| Molecular Formula |
C21H24N2O2.HCl |
|
| Molecular Weight (MW) | 372.89 | |
| SMILES | CC(C)NCCN1C2=C(C=C(C=C2)C(=O)C)C3=C1C=CC(=C3)C(=O)C.Cl | |
| InChIKey | IXRKBBVMDMKAEB-UHFFFAOYSA-N |
CBL0137 Hydrochloride is a small-molecule activator of p53 and inhibitor of NF-κB that targets the histone chaperone FACT (facilitates chromatin transcription) complex. By binding to FACT, it traps the complex on chromatin, causing depletion of soluble FACT and suppressing NF-κB signaling while inducing p53 activation. This dual action leads to inhibition of tumor cell proliferation and induction of apoptosis across various cancer models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
20 mg/mL
(53.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 20 mg/mL |
| Ethanol | Insoluble |
| DMSO |
19 mg/mL
(50.95 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 9 mg/mL |
| Ethanol | Insoluble |
| DMSO |
38 mg/mL
(101.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 24 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- CBL0137 Hydrochloride Mechanism of Action: FACT Complex Inhibition in Neuroblastoma Cell Research
- CBL0137 Hydrochloride Clinical Trials
- CBL0137 Hydrochloride Working Concentration | Cell Culture | Treatment
- CBL0137 Hydrochloride Solubility in DMSO
- CBL0137 Hydrochloride Stock Solution
- CBL0137 Hydrochloride Storage
- CBL0137 Hydrochloride Stability
- CBL0137 Hydrochloride Combination Database
- CBL0137 Hydrochloride Molecular Weight
- CBL0137 Hydrochloride SMILES
- CBL0137 Hydrochloride Chemical Structure (2D and 3D)
- CBL0137 Hydrochloride IC50 for Cell-based and Cell-free Assays
- CBL0137 Hydrochloride APExBIO (C3192)? Try a better option.
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- CBL0137 Hydrochloride SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.