Carvedilol Clinical Trials

Size	Price	Qty
50mg	USD 147
1g	USD 670

Clinical Trials

Carvedilol has been evaluated across numerous Phase 1 through Phase 4 clinical trials sponsored by academic research institutions, medical centers, and pharmaceutical organizations. These studies, which encompass recruiting, active, completed, and terminated recruitment statuses, primarily investigate therapeutic efficacy in cardiovascular and hepatic conditions—including congestive heart failure, stable angina pectoris, liver cirrhosis, portal hypertension, acute-on-chronic liver failure, and cardiotoxicity prevention in HER2-positive breast cancer. Ultimately, these investigations aim to characterize hemodynamic responses, vascular tone modulation, and overall patient outcomes across distinct disease contexts.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06449339	RECRUITING	Portal Hypertension; Hepatic Decompensation; Advanced Chronic Liver Disease	Chinese University of Hong Kong	2024-07-17	PHASE4
NCT06964464	RECRUITING	Heart Failure With Reduced Ejection Fraction (HFrEF); Sudden Cardiac Death; Ventricular Arrhythmia; Implantable Cardioverter Defibrillator (ICD); Beta-blocker Therapy; Cardiomyopathy	University of Rochester	2025-08-17	PHASE4
NCT06643221	RECRUITING	Leukemia; Hematopoetic Stem Cell Transplantation; Donor Lymphocyte Infusion; CAR T-Cell Therapy; Lymphoma; Cell Therapy	University of Arizona	2018-01-24	EARLY_PHASE1
NCT04499898	RECRUITING	Esophageal Varices	Sherief Abd-Elsalam	2018-10-01	PHASE2; PHASE3
NCT06594783	RECRUITING	Cirrhosis; Esophageal Varices	Taipei Veterans General Hospital, Taiwan	2025-01-06	PHASE4
NCT06594744	RECRUITING	Hepatocellular Carcinoma (HCC); Esophageal Varices	Taipei Veterans General Hospital, Taiwan	2024-10-01	PHASE4
NCT07577518	NOT_YET_RECRUITING	Chronic Coronary Syndrome	Seoul National University Hospital	2026-06-15
NCT07322237	RECRUITING	Cirrhotic Cardiomyopathy; Empagliflozin; Cardiometabolic Risk Factors; Cirrhosis	Post Graduate Institute of Medical Education and Research, Chandigarh	2026-04-01	PHASE4
NCT05194111	RECRUITING	Heart Failure; Heart Dysfunction	Virginia Commonwealth University	2022-08-11	PHASE1; PHASE2
NCT06861075	RECRUITING	Cirrhosis; Portal Hypertension Related to Cirrhosis	University Hospital, Clermont-Ferrand	2025-04-16
NCT06431919	RECRUITING	Decompensated Cirrhosis; Cirrhotic Cardiomyopathy; Cirrhosis, Liver; Left Ventricular Diastolic Dysfunction; Acute Kidney Injury	Post Graduate Institute of Medical Education and Research, Chandigarh	2025-06-10
NCT07465471	NOT_YET_RECRUITING	Liver Cirrhosis	Institute of Liver and Biliary Sciences, India	2026-03-01
NCT03418961	RECRUITING	Cardiotoxicity; HER2/Neu Positive; Metastatic Malignant Neoplasm in the Brain; Recurrent Breast Carcinoma; Stage IV Breast Cancer AJCC v6 and v7	SWOG Cancer Research Network	2017-11-01	PHASE3
NCT06078436	RECRUITING	Heart Failure With Reduced Ejection Fraction; Cardiogenic Shock	Min-Seok Kim	2024-01
NCT06263816	NOT_YET_RECRUITING	Asymptomatic Cirrhosis; Clinically Significant Portal Hypertension	University Hospital, Tours	2025-06-17	PHASE3
NCT07350070	NOT_YET_RECRUITING	HCC; Liver Cirrhosis; Portal Hypertension	Tongji Hospital	2025-12-31	PHASE2
NCT07521332	RECRUITING	Cirrhosis; Esophageal and Gastric Varices; Ascites; Hepatic Encephalopathy; Portal Vein Thrombosis; Portal Hypertension	Asian Institute Of Medical Sciences	2026-04-01	PHASE4
NCT05931276	RECRUITING	End-Stage Kidney Disease; End-Stage Renal Disease	VA Office of Research and Development	2024-05-22	PHASE3
NCT01212250	RECRUITING	Cirrhosis	Institute of Liver and Biliary Sciences, India	2010-09-01
NCT05872698	ACTIVE_NOT_RECRUITING	Cirrhosis, Liver; Portal Hypertension; Variceal Hemorrhage; Varices, Esophageal	King's College Hospital NHS Trust	2019-04-01	PHASE4
NCT07352228	ENROLLING_BY_INVITATION	Rebleeding of Portal Hypertension in Liver Cirrhosis; Propranolol; Carvedilol	Xijing Hospital	2026-01-01	PHASE4
NCT07103655	NOT_YET_RECRUITING	Hypertrophic Cardiomyopathy (HCM)	Second Affiliated Hospital, Zhejiang University, School of Medicine	2026-01-01	PHASE4
NCT03775096	ACTIVE_NOT_RECRUITING	REM Sleep Behavior Disorder; Pre-motor Parkinson Disease; Symptomatic Parkinson Disease	Michele Tagliati, MD	2019-04-04	PHASE2
NCT04218968	ACTIVE_NOT_RECRUITING	REM Sleep Behavior Disorder; Pre-motor Parkinson Disease; Symptomatic Parkinson Disease	Cedars-Sinai Medical Center	2019-12-30	PHASE2
NCT04121299	WITHDRAWN	Masked Hypertension	University of Alabama at Birmingham	2021-07	PHASE3
NCT06035978	UNKNOWN	Cardiovascular Diseases; Heart Failure With Reduced Ejection Fraction	University Hospital Ostrava	2024-03	PHASE4
NCT03879629	TERMINATED	Breast Cancer	Mayo Clinic	2019-08-21	PHASE2
NCT06844669	TERMINATED	HER2-positive Breast Cancer; HER2+ Breast Cancer	Washington University School of Medicine	2025-04-16	PHASE2
NCT06836778	NOT_YET_RECRUITING	Hepatocellular Carcinoma	Institute of Liver and Biliary Sciences, India	2025-02-20
NCT05553314	COMPLETED	Heart Failure With Preserved Ejection Fraction; Beta Blocker; Myocardial Strain	Seoul National University Bundang Hospital	2021-11-17	PHASE4
NCT04939883	UNKNOWN	Cancer	Hospital Sirio-Libanes	2021-08-01	PHASE4
NCT02993198	UNKNOWN	HER2 Positive Breast Cancer; Cardiovascular Abnormalities	Northwestern University	2015-04	PHASE2
NCT06470386	UNKNOWN	Hypertension, Portal	Shanghai Changzheng Hospital	2024-06	PHASE2; PHASE3
NCT07108075	RECRUITING	Liver Cirrhosis	Institute of Liver and Biliary Sciences, India	2025-06-14
NCT06696248	NOT_YET_RECRUITING	Hypertension, Portal	Shanghai Changzheng Hospital	2024-11-15	PHASE2; PHASE3
NCT06836856	RECRUITING	TBI Traumatic Brain Injury	Mansoura University	2025-01-20	PHASE1; PHASE2
NCT01608893	UNKNOWN	Atrial Fibrillation	University of Calgary	2012-05
NCT06304896	UNKNOWN	Chemotherapy Induced Systolic Dysfunction	Arab Contractors Medical Centre	2024-05-01	PHASE1
NCT03778554	ACTIVE_NOT_RECRUITING	Acute Myocardial Infarction; Non-ST Elevation Myocardial Infarction (nSTEMI); ST Elevation Myocardial Infarction	Bispebjerg Hospital	2018-12-17	PHASE4
NCT07397481	COMPLETED	Liver Cirrhosis; Arterial Hypertension	Kafrelsheikh University	2024-03-01	PHASE4
NCT06566794	COMPLETED	Drug Interaction	Helsinki University Central Hospital	2024-08-22
NCT05180292	UNKNOWN	Acute on Chronic Liver Failure	Institute of Liver and Biliary Sciences, India	2022-01-07
NCT05651789	UNKNOWN	Portal Hypertension; Varice Bleed; Cirrhosis, Liver	West China Hospital	2023-01
NCT05767229	COMPLETED	Portal Hypertension	Institute of Liver and Biliary Sciences, India	2023-03-13
NCT05021406	UNKNOWN	Liver Cirrhosis; Portal Hypertension	Beijing Friendship Hospital	2021-01-08
NCT04111133	UNKNOWN	Cirrhotic Cardiomyopathy; Left Ventricular Dysfunction; Cirrhosis, Liver; Portal Hypertension	Post Graduate Institute of Medical Education and Research, Chandigarh	2020-01-01
NCT06108518	UNKNOWN	Rheumatoid Arthritis	Tanta University	2024-06-01	EARLY_PHASE1
NCT03776955	UNKNOWN	Cirrhoses, Liver; Oesophageal Varices	King's College Hospital NHS Trust	2019-06-17	PHASE4
NCT04023110	COMPLETED	Cardiotoxicity; Risk Factor, Cardiovascular; Toxicity Due to Chemotherapy; Breast Cancer; Cardiomyopathies; Heart Failure	Abramson Cancer Center at Penn Medicine	2019-08-09	PHASE1
NCT06041932	UNKNOWN	Liver Cirrhosis	Institute of Liver and Biliary Sciences, India	2023-11-01
NCT05699824	UNKNOWN	Liver Cirrhosis	Institute of Liver and Biliary Sciences, India	2023-07-01
NCT04345796	COMPLETED	Tricuspid Regurgitation; Right Ventricular Dilatation	Asan Medical Center	2021-02-15	PHASE3
NCT05849766	COMPLETED	Dilated Cardiomyopathy	October 6 University	2023-04-27	PHASE3
NCT06298656	Not yet recruiting	Acute-On-Chronic Liver Failure	Institute of Liver and Biliary Sciences India	2024-03-10	--
NCT06078436	Recruiting	Heart Failure With Reduced Ejection Fraction\|Cardiogenic Shock	Min-Seok Kim\|Asan Medical Center	2024-01	Not Applicable
NCT05057572	COMPLETED	Liver Cirrhosis	Institute of Liver and Biliary Sciences, India	2021-10-01
NCT04254822	UNKNOWN	Liver Cirrhoses; Variceal Hemorrhage; Esophageal Varices	Air Force Military Medical University, China	2020-06-01
NCT06041932	Not yet recruiting	Liver Cirrhosis	Institute of Liver and Biliary Sciences India	2023-11-01	Not Applicable
NCT04543643	UNKNOWN	Cirrhosis Due to Hepatitis B; Cirrhosis Due to Hepatitis C; Gastroesophageal Varices	Tianjin Second People's Hospital	2021-11-01	PHASE3
NCT05553717	UNKNOWN	IHD; Gastro-Intestinal Disorder; Aspirin Induced Esophageal Ulcer	Tanta University	2022-10
NCT06015373	COMPLETED	Clinically Significant Portal Hypertension	Centro Hospitalar De São João, E.P.E.	2023-06-01
NCT04190433	WITHDRAWN	Breast Carcinoma; Hematopoietic and Lymphoid Cell Neoplasm; Lymphoma; Sarcoma	Mayo Clinic	2020-09-01	PHASE2
NCT06004453	Recruiting	Heart Failure	Novartis Pharmaceuticals\|Novartis	2023-04-04	--
NCT05767229	Recruiting	Portal Hypertension	Institute of Liver and Biliary Sciences India	2023-03-13	Not Applicable
NCT04198259	UNKNOWN	Gastric Varices Bleeding; Liver Cirrhoses	Air Force Military Medical University, China	2020-06-01
NCT03736265	UNKNOWN	Cirrhosis, Liver; Portal Hypertension	Beijing Friendship Hospital	2017-10-09
NCT04049786	UNKNOWN	Obesity; Bariatric Surgery; Roux-en Y Gastric Bypass	Natalia Valadares de Moraes	2019-06-01	PHASE4
NCT02717507	COMPLETED	Hematopoietic and Lymphoid Cell Neoplasm; Malignant Solid Neoplasm	Children's Oncology Group	2016-04-04	PHASE2
NCT05179070	UNKNOWN	Heart Failure With Reduced Ejection Fraction HFrEF	Universitas Sebelas Maret	2021-09-10	PHASE4
NCT03980249	WITHDRAWN	Glioblastoma; Glioblastoma Multiforme	West Virginia University	2020-09	EARLY_PHASE1
NCT02177175	COMPLETED	Breast Cancer	Memorial Sloan Kettering Cancer Center	2014-06-24	PHASE2
NCT03542058	UNKNOWN	Chemotherapy Related Cardiac Dysfunction	Makerere University	2018-06	PHASE3
NCT02944201	UNKNOWN	Prostate Cancer	Montefiore Medical Center	2017-04-01	PHASE2
NCT03720067	UNKNOWN	Cirrhosis; Portal Hypertension; Variceal Hemorrhage	Universidade Federal do Rio de Janeiro	2019-01-25	PHASE2; PHASE3
NCT02230891	COMPLETED	Hypertension; Diabetes; Cardiovascular Disease	VA Office of Research and Development	2014-10-01	PHASE2
NCT03948685	UNKNOWN	Heart Failure With Preserved Ejection Fraction	Yonsei University	2019-05	PHASE4
NCT03069339	UNKNOWN	Cirrhosis	Institute of Liver and Biliary Sciences, India	2017-03-15
NCT03861598	TERMINATED	Glioblastoma Multiforme; Glioblastoma	West Virginia University	2019-07-19	EARLY_PHASE1
NCT03538015	TERMINATED	Hypoglycemia Unawareness	Owen Chan, PhD	2019-04-22	PHASE2
NCT02945982	UNKNOWN	Portal Hypertension	ShuGuang Hospital	2018-04-05	PHASE4
NCT02925975	UNKNOWN	Portal Hypertension; Cirrhosis	Changqing Yang	2015-01	PHASE4
NCT02357004	WITHDRAWN	Hypertensive	University of Alabama at Birmingham	2015-02
NCT02907749	COMPLETED	Cirrhosis; Portal Hypertension	Changqing Yang	2018-01-01	PHASE4
NCT03587558	UNKNOWN	Ventricular Premature Complexes; Outflow Tract; Carvedilol	Keimyung University Dongsan Medical Center	2017-09-05	PHASE4
NCT02946892	COMPLETED	Single Ventricle; Fontan	University of Texas Southwestern Medical Center	2016-11	PHASE4
NCT03576664	COMPLETED	Sleep Deprivation; Sleep Wake Disorders; Sleep	Gitte Moos Knudsen	2018-08-28	EARLY_PHASE1
NCT02507011	TERMINATED	Pulmonary Arterial Hypertension	University of Minnesota	2016-01-31	PHASE2
NCT02066649	WITHDRAWN	Portal Hypertension Related to Cirrhosis	Rutgers, The State University of New Jersey	2018-07	PHASE3
NCT02056626	COMPLETED	Hypertension	University of Rochester	2011-03	PHASE4
NCT02695732	UNKNOWN	Liver Cirrhosis; Esophageal and Gastric Varices	Shanghai Zhongshan Hospital	2015-12	PHASE4
NCT02619526	UNKNOWN	Heart Failure	Dong-A University	2016-12
NCT03209180	UNKNOWN	Heart Failure With Reduced Ejection Fraction	Seoul National University Bundang Hospital	2016-10-27	PHASE4
NCT02638415	UNKNOWN	Gastroesophageal Varices; Cirrhosis	Shanghai Zhongshan Hospital	2015-12	PHASE4
NCT01659346	WITHDRAWN	Hepatocellular Carcinoma With Portal Vein Thrombosis	Institute of Liver and Biliary Sciences, India	2016-02
NCT03169426	COMPLETED	Myocardial Infarction	Seoul National University Hospital	2017-05-17	PHASE4
NCT02251509	UNKNOWN	Atrial Fibrillation	Creighton University	2016-12	PHASE4
NCT02583698	COMPLETED	Acute on Chronic Liver Failure	Institute of Liver and Biliary Sciences, India	2015-10-01
NCT02385422	UNKNOWN	Liver Cirrhosis; Esophageal and Gastric Varices; Hemorrhage	Shanghai Zhongshan Hospital	2015-03	PHASE4
NCT02975323	UNKNOWN	Portal Hypertension	Aga Khan University	2014-12	PHASE3
NCT01724450	COMPLETED	Breast Cancer; Heart Failure; Cardiotoxicity	University of Sao Paulo	2013-04	PHASE3
NCT03867994	COMPLETED	Contrast-induced Nephropathy	rabab ahmed mohamed	2016-02-01	PHASE2
NCT02504723	COMPLETED	Esophageal and Gastric Varices	Kaohsiung Veterans General Hospital.	2011-12	PHASE4
NCT02465645	COMPLETED	Cirrhosis With Esophageal Varices	Institute of Liver and Biliary Sciences, India	2015-06-01
NCT02809820	COMPLETED	Acute Coronary Syndrome	Federico II University	2016-05	PHASE4
NCT01354444	COMPLETED	Alzheimer's Disease	Johns Hopkins University	2011-06	PHASE4
NCT02294292	COMPLETED	Diastolic Dysfunction; Chronic Liver Disease	Institute of Liver and Biliary Sciences, India	2014-07-01
NCT01586156	COMPLETED	Pulmonary Hypertension	The Cleveland Clinic	2012-12
NCT01656005	COMPLETED	Chronic Obstructive Pulmonary Disease	University of Dundee	2012-08	PHASE4
NCT02137733	UNKNOWN	Chronic Heart Failure	Mebix Inc	2013-06
NCT01723371	WITHDRAWN	Pulmonary Arterial Hypertension	The Hospital for Sick Children	2012-09	PHASE1; PHASE2
NCT01196481	COMPLETED	Cirrhosis	Institute of Liver and Biliary Sciences, India	2012-12
NCT01383044	TERMINATED	Variceal Bleeding	E-DA Hospital	2011-07-08	PHASE4
NCT01059396	COMPLETED	Portal Hypertension Gastropathy; Esophageal Varices; Spontaneous Bacterial Peritonitis; Hepatic Encephalopathy; Ascites	Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau	2010-01-28	PHASE4
NCT01155635	COMPLETED	Myocardial Infarction	Takeshi Morimoto	2010-07	PHASE4
NCT02120339	TERMINATED	Pulmonary Hypertension; Cardiac MRI <40	University of Minnesota	2014-05	PHASE1
NCT02012075	UNKNOWN	Heart Failure	Jiangsu HengRui Medicine Co., Ltd.	2013-12	PHASE3
NCT02286934	COMPLETED	Healthy	Seoul National University Hospital	2014-09	PHASE1
NCT00964678	COMPLETED	Pulmonary Arterial Hypertension	Virginia Commonwealth University	2010-06	PHASE1; PHASE2
NCT01171183	COMPLETED	Cocaine Dependence; Cocaine Withdrawal	University of Arkansas	2010-08	PHASE2
NCT01196507	COMPLETED	Cirrhosis	Institute of Liver and Biliary Sciences, India	2010-11
NCT01970059	UNKNOWN	Hypertension	Jiangsu HengRui Medicine Co., Ltd.	2013-10	PHASE3
NCT01756430	COMPLETED	Hypertension	Chong Kun Dang Pharmaceutical	2012-12	PHASE3
NCT02547597	COMPLETED	Stable Angina Pectoris	Gachon University Gil Medical Center	2011-04	PHASE4
NCT01793870	COMPLETED	Metabolic, Cardiovascular	GlaxoSmithKline	2013-01-15	PHASE1
NCT00430040	TERMINATED	Diabetes Mellitus, Type 2; Hypertension	University at Buffalo	2007-02	PHASE4
NCT01568645	WITHDRAWN	Pulmonary Hypertension	National Heart, Lung, and Blood Institute (NHLBI)	2012-03-02	PHASE1
NCT01243827	UNKNOWN	Hypertension	Yoshio Matsui	2010-11	PHASE4
NCT00566969	COMPLETED	Cocaine Dependence; Opiate Dependence	Yale University	2007-09
NCT01425164	UNKNOWN	Coronary Heart Disease; Angina; Hemodialysis	University of Campania Luigi Vanvitelli	2011-01	PHASE4
NCT01413048	UNKNOWN	Essential Hypertension	Ahn-Gook Pharmaceuticals Co.,Ltd	2011-01	PHASE3
NCT01110824	COMPLETED	Acute Myeloid Leukemia; Precursor-cell Lymphoblastic Leukemia-Lymphoma; Lymphoid Neoplasm; Multiple Myeloma; Lymphoma; Autologous Hematopoietic Stem Cell Transplantation	Hospital Clinic of Barcelona	2008-04	PHASE3
NCT01577914	COMPLETED	Fasting State	IPCA Laboratories Ltd.	2011-07	PHASE1
NCT01221792	UNKNOWN	Post-Traumatic Stress Disorder	Columbia Northwest Pharmaceuticals	2010-10	PHASE2
NCT01270672	COMPLETED	Mood Disorder; Substance-Related Disorders; Amphetamine-Related Disorders	University Hospital, Basel, Switzerland	2011-01
NCT02406586	COMPLETED	Hypertension; Diabetes	Emory University	2009-07
NCT01070641	UNKNOWN	Portal Hypertension	Aga Khan University	2002-06	PHASE4
NCT00638222	TERMINATED	Vascular Disease; Kidney Disease	University of Toledo Health Science Campus	2008-05
NCT00524134	TERMINATED	Epilepsy	Columbia University	2008-12	PHASE2; PHASE3
NCT00553969	COMPLETED	Pre-hypertension	University of Minnesota	2007-11	PHASE1; PHASE2
NCT00827775	COMPLETED	Intradialytic Hypertension	University of Texas Southwestern Medical Center	2009-06	PHASE4
NCT00313157	COMPLETED	Atrial Fibrillation	Asker & Baerum Hospital	2006-04	PHASE3
NCT00669279	COMPLETED	Hypertension	University of Florida	2008-04	PHASE4
NCT01178528	COMPLETED	Heart Failure	IRCCS San Raffaele	2009-09	PHASE3
NCT00459056	COMPLETED	Abdominal Obesity; Hypertension	St. Paul Heart Clinic	2007-04	PHASE3
NCT00657241	COMPLETED	Hypertension	State University of New York at Buffalo	2008-04	PHASE3
NCT01103154	COMPLETED	Variceal Rebleeding	E-DA Hospital	2005-03	PHASE4
NCT00496834	COMPLETED	Hypertension	Organon and Co	2008-02-01	PHASE4
NCT00673075	COMPLETED	Hypertension; Coronary Artery Disease	Forest Laboratories	2008-05	PHASE4
NCT00742508	COMPLETED	Heart Failure, Congestive	GlaxoSmithKline	2008-08-28	PHASE1
NCT00493480	COMPLETED	Cirrhosis; Portal Hypertension	Hvidovre University Hospital	2003-09	PHASE3
NCT00292162	COMPLETED	Chronic Heart Failure; Atrial Fibrillation	NHS Greater Glasgow and Clyde	2007-01
NCT00819845	UNKNOWN	Duchenne Muscular Dystrophy; Becker Muscular Dystrophy	Catholic University, Italy	2008-12	PHASE4
NCT00433043	TERMINATED	Congestive Heart Failure	St. Luke's-Roosevelt Hospital Center	2007-01	PHASE4
NCT00295542	COMPLETED	Hypertension	University of Vigo	2000-03	PHASE4
NCT01798992	COMPLETED	Idiopathic Dilated Cardiomyopathy	University of Colorado, Denver	2000-09	PHASE4
NCT00391846	COMPLETED	Heart Failure; Ventricular Dysfunction, Left	AstraZeneca	2006-10	PHASE4
NCT00732511	UNKNOWN	Endothelial Function; Diabetes Mellitus; Hypertension	State University of New York - Downstate Medical Center	2008-04	PHASE4
NCT00606775	UNKNOWN	Duchenne Muscular Dystrophy; Cardiomyopathies	Suzuka Hospital	2007-12	PHASE4
NCT00108082	COMPLETED	Hypertrophy, Left Ventricular	GlaxoSmithKline	2005-01	PHASE3
NCT00624065	COMPLETED	Hypertension	GlaxoSmithKline	2008-03	PHASE3
NCT00508365	COMPLETED	Hypertension	GlaxoSmithKline	2007-09-25	PHASE1
NCT00642434	COMPLETED	Diabetes	University of New Mexico	2004-01	PHASE4
NCT03370835	COMPLETED	Pulmonary Disease, Chronic Obstructive; Asthma; Adverse Effect of Beta-adrenoreceptor Antagonists	VA Greater Los Angeles Healthcare System	2004-06	PHASE4
NCT00384566	WITHDRAWN	Heart Failure; Chronic Obstructive Airway Disease	The Alfred	2005-06	PHASE4
NCT00323037	COMPLETED	Congestive Heart Failure	CTI-1, LLC	2006-03	PHASE3
NCT00347360	COMPLETED	Hypertension	GlaxoSmithKline	2006-07	PHASE3
NCT00273052	COMPLETED	Hypertension	GlaxoSmithKline	2006-01-05	PHASE3
NCT00585091	COMPLETED	Heart Failure	University of Utah	2003-10
NCT00444834	TERMINATED	Hypertension	Egalet Ltd	2007-04	PHASE2
NCT00924833	COMPLETED	Hypoxia; Altitude; Heart Failure	Istituto Auxologico Italiano	2006-05	PHASE4
NCT00272805	COMPLETED	Chronic Heart Failure	Cardiovascular Clinical Sciences Inc	2005-10	PHASE3
NCT00123604	COMPLETED	Hypertension; Type 2 Diabetes Mellitus	St. Paul Heart Clinic	2004-06	PHASE4
NCT00123903	TERMINATED	Heart Failure, Congestive and Microalbuminuria	GlaxoSmithKline	2005-07	PHASE3
NCT00129363	COMPLETED	Congestive Heart Failure	Shaddy, Robert, M.D.	2002-01	PHASE3
NCT00864149	COMPLETED	Healthy	Actavis Inc.	2005-10	PHASE1
NCT00864435	COMPLETED	Healthy	Actavis Inc.	2005-10	PHASE1
NCT01261065	COMPLETED	Heart Failure; Cardiomyopathy	Michael E. DeBakey VA Medical Center	2001-12	PHASE4
NCT00052026	COMPLETED	Congestive Heart Failure	Shaddy, Robert, M.D.	2000-05	PHASE3
NCT00802230	COMPLETED	Heart Failure	University of Utah	2002-09	PHASE4
NCT00060918	COMPLETED	Hypertension	GlaxoSmithKline	2001-06	PHASE4
NCT00648622	COMPLETED	Healthy	Mylan Pharmaceuticals Inc	2004-04	PHASE1
NCT00060931	COMPLETED	Hypertension	GlaxoSmithKline	2001-06	PHASE4
NCT00650416	COMPLETED	Healthy	Mylan Pharmaceuticals Inc	2004-03	PHASE1
NCT01557140	COMPLETED	Chagas Cardiomyopathy; Heart Failure; Dilated Cardiomyopathy	Federal University of Minas Gerais	2003-05	PHASE4
NCT00775619	COMPLETED	Healthy	Ranbaxy Laboratories Limited	2003-09
NCT00776113	COMPLETED	Healthy	Ranbaxy Laboratories Limited	2003-08
NCT01064154	COMPLETED	Healthy	Dr. Reddy's Laboratories Limited	2002-05	PHASE1
NCT01064180	COMPLETED	Healthy	Dr. Reddy's Laboratories Limited	2002-05	PHASE1
NCT02832089	COMPLETED	Atrial Fibrillation	Andhra Medical College	2000-12	PHASE3
NCT00834795	COMPLETED	Healthy	Teva Pharmaceuticals USA	2001-12	PHASE1
NCT00834873	COMPLETED	Healthy	Teva Pharmaceuticals USA	2001-12	PHASE1
NCT00000294	COMPLETED	Cocaine-Related Disorders	National Institute on Drug Abuse (NIDA)	1998-09	PHASE2
NCT00402376	TERMINATED	Heart Failure	University Hospital, Strasbourg, France	2007-04	PHASE4
NCT00198614	COMPLETED	Coronary Disease; Atrial Fibrillation	Ministry of Health, Labour and Welfare, Japan	2005-01
NCT00497003	COMPLETED	Endothelial Function; Beta Blocker	Bispebjerg Hospital	2004-02	PHASE4
NCT00348530	UNKNOWN	Systolic Heart Failure; Myocardial Disease; Cardiomyopathy	Medical University of Silesia	2006-01	PHASE4
NCT00214318	COMPLETED	Heart Failure	University of Wisconsin, Madison	2005-01
NCT00344513	COMPLETED	Heart Failure, Congestive	GlaxoSmithKline	2002-12-16	PHASE4
NCT00374465	UNKNOWN	Dilated Cardiomyopathy	Medical University of Silesia	2006-01	PHASE4
NCT00240656	COMPLETED	Hypertension, Pulmonary	Hebei Medical University	2005-10	PHASE1
NCT00381030	COMPLETED	Heart Failure, Congestive	Denver Health and Hospital Authority	2002-10	PHASE4
NCT00517725	COMPLETED	Chronic Heart Failure	Centro Cardiologico Monzino	2007-07	PHASE4
NCT00004854	COMPLETED	Heart Diseases	National Center for Research Resources (NCRR)		PHASE1

(data from https://clinicaltrials.gov, updated on 2025-06-22)

Check the Carvedilol product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Carvedilol acts as a non-selective antagonist of beta-1, beta-2, and alpha-1 adrenergic receptors, blocking norepinephrine binding to inhibit intracellular G-protein-mediated signaling pathways in vascular smooth muscle and cardiac tissue. This dual antagonism induces peripheral vasodilation and attenuates cardiac workload by slowing heart rate and reducing contractile force, providing hemodynamic benefits in clinical conditions such as congestive heart failure, hypertension, and portal hypertension.

Appendix RUO and cGMP Quality Standards

Quality Dimension	RUO (Research Use Only)	cGMP (Current Good Manufacturing Practice)
Clinical Applicability	Prohibited in human clinical trials or medical diagnostics.	Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status	Non-regulated grade; exempt from drug manufacturing laws.	Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment	Unclassified analytical or research laboratories.	Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control	Basic purity and activity testing.	Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation	Basic equipment calibration; no process validation required.	Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance	Vendor self-declared without required formal QMS.	Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact	High risk of IND rejection if used as a critical raw material.	Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).