CAS No. 53716-49-7
Batch:
Purity:99.98
Chemical Structure
Check the
Carprofen
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 53716-49-7 | |
|---|---|---|
| Molecular Formula |
C15 H12ClNO2 |
|
| Molecular Weight (MW) | 273.71 | |
| SMILES | CC(C1=CC2=C(C=C1)C3=C(N2)C=CC(=C3)Cl)C(=O)O |
Biological Activity
Carprofen is a non-steroidal anti-inflammatory drug (NSAID) that acts as a selective inhibitor of canine cyclooxygenase-2 (COX-2) with an IC50 of. By inhibiting COX-2, carprofen suppresses the synthesis of pro-inflammatory prostaglandins, leading to reduced inflammatory responses and pain signaling. It demonstrates selectivity for COX-2 over COX-1, making it a key agent in studying cyclooxygenase pathway modulation and inflammatory regulation in veterinary models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
55 mg/mL
(200.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 55 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.