PR-171 (Carfilzomib) is a potent, selective, and irreversible 20S proteasome inhibitor. It affects NF-κB and apoptotic signaling by binding to the β5 subunit to block polyubiquitinated protein degradation, effectively inducing apoptosis and inhibiting tumor cell proliferation.
PR-171 (Carfilzomib) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for PR-171 (Carfilzomib) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.