CAS No. 187739-60-2

Batch: Purity:99.97
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CarboxyaMidotriazole orotate Chemical Structure
Chemical Structure
Check the CarboxyaMidotriazole orotate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]triazole-4-carboxamide;2,4-dioxo-1H-pyrimidine-6-carboxylic acid
CAS Number 187739-60-2
Molecular Formula

C22H16Cl3N7O6
Molecular Weight (MW) 580.76
SMILES NC(=O)C1=C(N)[N](CC2=CC(=C(C(=C2)Cl)C(=O)C3=CC=C(Cl)C=C3)Cl)N=N1.OC(=O)C4=CC(=O)NC(=O)N4
InChIKey MNWOBDDXRRBONM-UHFFFAOYSA-N

Ordering Information

Biological Activity

Carboxyamidotriazole orotate is an orally bioavailable, cytostatic signal transduction inhibitor targeting non-voltage-operated calcium channels. By suppressing calcium influx into cells, it impairs calcium-dependent signaling pathways necessary for tumor progression. Consequently, it leads to the downregulation of downstream cellular responses, inhibiting angiogenesis, endothelial cell proliferation, tumor invasion, and metastasis across various cancer models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 25 mg/mL (43.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.