CAS No. 404-86-4

Batch: Purity:99.7
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Capsaicin(Vanilloid) Chemical Structure
Chemical Structure
Check the Capsaicin(Vanilloid) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
CAS Number 404-86-4
Molecular Formula

C18H27NO3
Molecular Weight (MW) 305.41
SMILES CC(C)C=CCCCCC(=O)NCC1=CC(=C(C=C1)O)OC
InChIKey YKPUWZUDDOIDPM-SOFGYWHQSA-N

Biological Activity

Capsaicin is a naturally occurring vanilloid compound that acts as a transient receptor potential vanilloid 1 (TRPV1) agonist. Activation of TRPV1 ion channels by capsaicin induces calcium influx in sensory neurons, triggering membrane depolarization and activation of nociceptive signaling pathways. This cation influx leads to transient burning sensations followed by neuronal desensitization, modulating pain perception and inflammatory responses. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 54 mg/mL (176.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 54 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Caterina MJ, et al. Nature. 1997;389(6653):816-24.

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Note: Technical data last updated: Sep 1, 2026.