CAS No. 154361-50-9
| IUPAC Name | pentyl N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate | |
|---|---|---|
| CAS Number | 154361-50-9 | |
| Molecular Formula |
C15H22FN3O6 |
|
| Molecular Weight (MW) | 359.35 | |
| SMILES | CCCCCOC(=O)NC1=NC(=O)N(C=C1F)C2C(C(C(O2)C)O)O | |
| InChIKey | GAGWJHPBXLXJQN-UORFTKCHSA-N |
Capecitabine is an orally bioavailable fluoropyrimidine carbamate prodrug of 5-fluorouracil (5-FU) that functions as a DNA synthesis inhibitor. Upon tumor-selective enzymatic activation to 5-FU, it is metabolized into active metabolites FdUMP and FUTP. FdUMP inhibits thymidylate synthase to suppress DNA synthesis, while FUTP incorporates into RNA strands to disrupt protein synthesis. These combined actions reduce cell proliferation, cause DNA condensation, and induce apoptosis. [1][2]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
72 mg/mL
(200.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 72 mg/mL |
| Water | 6 mg/mL |
| DMSO |
72 mg/mL
(200.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 72 mg/mL |
| Water | 18 mg/mL |
| DMSO |
72 mg/mL
(200.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 72 mg/mL |
| Water | 6 mg/mL |
| DMSO |
72 mg/mL
(200.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 72 mg/mL |
| Water | 6 mg/mL |
| DMSO |
72 mg/mL
(200.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 72 mg/mL |
| Water | 6 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Capecitabine Mechanism of Action: Thymidylate Synthase Inhibition in Breast Cancer Cell Research
- Capecitabine Clinical Trials
- Capecitabine Working Concentration | Cell Culture | Treatment
- Capecitabine Solubility in DMSO
- Capecitabine Stock Solution
- Capecitabine Storage
- Capecitabine Stability
- Capecitabine Combination Database
- Capecitabine Molecular Weight
- Capecitabine SMILES
- Capecitabine Chemical Structure (2D and 3D)
- Capecitabine IC50 for Cell-based and Cell-free Assays
- Capecitabine Sigma (PHR1405)? Try a better option.
- Capecitabine Cayman (10487)? Try a better option.
- Capecitabine APExBIO (A8647)? Try a better option.
- Capecitabine MedChemExpress (HY-B0016)? Try a better option.
- Capecitabine SDS｜MSDS