CAS No. 842133-18-0

Batch: Purity:99.92
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Canagliflozin (JNJ-28431754) Chemical Structure
Chemical Structure
Check the Canagliflozin (JNJ-28431754) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2S,3R,4R,5S,6R)-2-[3-[[5-(4-fluorophenyl)thiophen-2-yl]methyl]-4-methylphenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
CAS Number 842133-18-0
Molecular Formula

C24H25FO5S
Molecular Weight (MW) 444.52
SMILES CC1=C(C=C(C=C1)C2C(C(C(C(O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F
InChIKey XTNGUQKDFGDXSJ-ZXGKGEBGSA-N

Ordering Information

Biological Activity

Canagliflozin is a highly potent and selective sodium-glucose transport protein 2 (SGLT2) inhibitor that targets CHO-hSGLT2, CHO-rSGLT2, and CHO-mSGLT2. By blocking sodium-dependent renal glucose reabsorption, canagliflozin suppresses cellular glucose uptake, increases urinary glucose excretion, and exerts pronounced anti-hyperglycemic activity in diabetic rodent models. [1][2]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 89 mg/mL (200.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.