CAS No. 112965-21-6

Batch: Purity:97
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MC903 (Calcipotriene) Chemical Structure
Chemical Structure
Check the MC903 (Calcipotriene) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name trans-(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
CAS Number 112965-21-6
Molecular Formula

C27H40O3
Molecular Weight (MW) 412.60
SMILES CC(C=CC(C1CC1)O)C2CCC3C2(CCCC3=CC=C4CC(CC(C4=C)O)O)C
InChIKey LWQQLNNNIPYSNX-UROSTWAQSA-N

Ordering Information

Biological Activity

MC903 (Calcipotriene) is a synthetic vitamin D3 analogue that acts as a potent agonist of the vitamin D receptor (VDR). By binding to VDR, MC903 regulates gene expression to suppress epidermal keratinocyte proliferation and promote cellular differentiation. Additionally, topical application of MC903 stimulates thymic stromal lymphopoietin (TSLP) expression in keratinocytes, modulating immune and inflammatory pathways in cutaneous tissue models. [1]

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 83 mg/mL (201.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 83 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.