CAS No. 81409-90-7
Batch:
Purity:99.82
Chemical Structure
Check the
Cabergoline
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 81409-90-7 | |
|---|---|---|
| Molecular Formula |
C26H37N5O2 |
|
| Molecular Weight (MW) | 451.60 | |
| SMILES | CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C |
Cabergoline (FCE-21336) is an ergot-derived, long-acting dopamine receptor agonist and potent prolactin inhibitor. By selectively activating dopamine D2 receptors, cabergoline suppresses prolactin secretion in pituitary lactotrophs and downregulates prolactin-mediated downstream signaling pathways. Furthermore, cabergoline targets vascular endothelial growth factor receptor 2 (VEGFR2) phosphorylation, leading to decreased vascular endothelial cell permeability and inhibition of angiogenesis. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
90 mg/mL
(199.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 90 mg/mL |
| Water | Insoluble |
| DMSO |
90 mg/mL
(199.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 90 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.