CAS No. 300802-28-2
| IUPAC Name | N-[2,7-bis(piperidin-1-ylsulfonyl)fluoren-9-ylidene]hydroxylamine | |
|---|---|---|
| CAS Number | 300802-28-2 | |
| Molecular Formula |
C23H27N3O5S2 |
|
| Molecular Weight (MW) | 489.61 | |
| SMILES | C1CCN(CC1)S(=O)(=O)C2=CC3=C(C=C2)C4=C(C3=NO)C=C(C=C4)S(=O)(=O)N5CCCCC5 | |
| InChIKey | XYZXEEIUKQGUHB-UHFFFAOYSA-N |
CA3 (CIL56) is a potent inhibitor of YAP1/TEAD transcriptional activity that primarily targets therapy-resistant esophageal adenocarcinoma cells displaying high YAP1 levels and cancer stem cell properties. Mechanistically, CA3 suppresses Hippo/YAP1 pathway downstream signaling to inhibit cellular proliferation, survival, and stemness. Furthermore, CA3 treatment triggers ferroptotic cell death accompanied by the generation of iron-dependent reactive oxygen species in target cancer cells. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
97 mg/mL
(198.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
98 mg/mL
(200.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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