CAS No. 864289-85-0
Batch:
Purity:99.98
Chemical Structure
Check the
C-021
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-cycloheptyl-6,7-dimethoxy-2-(4-piperidin-1-ylpiperidin-1-yl)quinazolin-4-amine | |
|---|---|---|
| CAS Number | 864289-85-0 | |
| Molecular Formula |
C27H41N5O2 |
|
| Molecular Weight (MW) | 467.65 | |
| SMILES | COC1=CC2=NC(=NC(=C2C=C1OC)NC3CCCCCC3)N4CCC(CC4)N5CCCCC5 | |
| InChIKey | WYVBISCFCHREDA-UHFFFAOYSA-N |
C-021 is a potent CC chemokine receptor 4 (CCR4) antagonist that inhibits ligand-induced cell chemotaxis. Blockade of CCR4 signaling with C-021 suppresses downstream TGF-β/Smad pathway activation, resulting in reduced fibroblast activation and attenuated tissue fibrosis in vivo. In addition, targeted CCR4 inhibition by C-021 diminishes neuropathic hypersensitivity and enhances the analgesic potency of opioid therapeutics in preclinical models. [1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
150 mg/mL
(320.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 23 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.