Clinical Trials

Bupivacaine has been extensively evaluated across numerous clinical trials spanning Early Phase 1 through Phase 4 for indications such as postoperative pain, labor pain, and regional anesthesia in procedures including cervical spine fusion, shoulder surgery, and breast cancer operations. Sponsored by leading academic institutions and healthcare systems—including Hartford Hospital, The Cleveland Clinic, and the University of Minnesota—these studies encompass actively recruiting, non-recruiting, completed, and terminated statuses within regional analgesia research.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04110132 NOT_YET_RECRUITING
Postoperative Pain
University of Alexandria
 2028-07-01
NCT06635889 RECRUITING
Nephrolithiasis
University of Chicago
 2025-03-26 PHASE2
NCT07212114 RECRUITING
Total Ankle Arthroplasty; Postsurgical Analgesia
Emory University
 2025-11-17 PHASE3
NCT06784180 WITHDRAWN
Opioid Use Disorder
University of North Carolina, Chapel Hill
 2026-02 PHASE4
NCT07665762 NOT_YET_RECRUITING
Pain, Postoperative; Liposomal Bupivacaine; Dexamethasone; Supraclavicular Brachial Plexus Block; High Risk Factors; Distal Radial Fracture
The University of Hong Kong
 2026-06-15 PHASE3
NCT07641647 NOT_YET_RECRUITING
Lung Transplantation; Pain Management; Liposomal Bupivacaine
Second Affiliated Hospital, Zhejiang University, School of Medicine
 2026-07-01 PHASE4
NCT07393386 NOT_YET_RECRUITING
Pain Management
Shanghai Pulmonary Hospital, Shanghai, China
 2026-02-01 PHASE4
NCT06942689 RECRUITING
Optimal Volume of Liposomal Bupivacaine
Nanjing First Hospital, Nanjing Medical University
 2025-06-01 PHASE4
NCT07176533 NOT_YET_RECRUITING
Tonsillitis
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
 2026-01-01
NCT07631091 NOT_YET_RECRUITING
Hip Osteoarthritis; Hip Arthroplasty Replacement; Postoperative Pain After Ambulatory Surgery
University of Turku
 2026-06 PHASE4
NCT07358299 NOT_YET_RECRUITING
Anesthesia, Spinal; Hip Fractures
Centre of Postgraduate Medical Education
 2026-01-15 PHASE4
NCT07216820 RECRUITING
Shoulder Surgery; Obesity
University of North Carolina, Chapel Hill
 2026-01-21
NCT03351348 ACTIVE_NOT_RECRUITING
Breast Cancer
Memorial Sloan Kettering Cancer Center
 2017-11-16 PHASE3
NCT07246642 NOT_YET_RECRUITING
Erectile Dysfunction (ED)
Wake Forest University Health Sciences
 2026-09 PHASE4
NCT05736549 RECRUITING
Total Knee Replacement; Knee Arthroplasty
Yale University
 2023-02-07 PHASE2
NCT03121261 ACTIVE_NOT_RECRUITING
Inguinal Hernia; Spinal Anesthesia
University Hospital Dubrava
 2017-05-01 PHASE4
NCT07670078 NOT_YET_RECRUITING
Modified Radical Mastectomy; Post Operative Pain, Acute; Facial Plane Blocks
Cumhuriyet University
 2026-08-25
NCT03214510 ACTIVE_NOT_RECRUITING
Liver and Intrahepatic Bile Duct Disorder
M.D. Anderson Cancer Center
 2017-10-04 PHASE3
NCT07429019 NOT_YET_RECRUITING
Pain After Surgery; PSP; Chronic Pain Syndrome; Local Anesthesia Infiltration
Hadassah Medical Organization
 2026-07-01
NCT07606911 NOT_YET_RECRUITING
Acute Pain; Orthopaedic Surgery
Shanghai Jiao Tong University Affiliated Sixth People's Hospital
 2026-10-01 PHASE4
NCT06146842 RECRUITING
Labor Pain
Brigham and Women's Hospital
 2023-12-01 PHASE4
NCT07468604 RECRUITING
Autonomic Dysfunction
University Health Network, Toronto
 2026-05-19 PHASE4
NCT06338865 RECRUITING
Laparoscopic Surgery
Cedars-Sinai Medical Center
 2024-05-03
NCT07441902 RECRUITING
Video-assisted Thoracoscopic Surgery (VATS); Pain Management; Liposomal Bupivacaine; Rhomboid Intercostal Block
Beijing Tiantan Hospital
 2026-03-02
NCT07073209 RECRUITING
Hip Fractures
Weill Medical College of Cornell University
 2025-07-10
NCT05830630 RECRUITING
Perineural; Methylene Blue; Lower Limb Amputation
Tanta University
 2023-05-01
NCT07754916 NOT_YET_RECRUITING
Thoracic Surgery; Glycemic Variability
Xiangya Hospital of Central South University
 2026-08-01
NCT07440576 RECRUITING
Pelvic Organ Prolapse (POP); Postoperative Pain
Erkan Gol
 2026-03-09
NCT06004882 RECRUITING
Peripheral Nerve Stimulation; Genicular Nerves; Chronic Knee Pain
M.D. Anderson Cancer Center
 2023-08-10
NCT06411795 RECRUITING
Duodenal Neoplasm; Pancreatic Neoplasm
Masonic Cancer Center, University of Minnesota
 2023-11-10 PHASE2
NCT07558642 NOT_YET_RECRUITING
Stellate Ganglion Block
Antalya Training and Research Hospital
 2026-08-06
NCT07747584 NOT_YET_RECRUITING
Postoperative Pain
Allied Hospital Faisalabad
 2026-08
NCT05461092 RECRUITING
Delirium; Pain, Back; Spinal Fusion; Thoracolumbar Interfascial Plane Block
University of Iowa
 2024-01-01 EARLY_PHASE1
NCT06692010 NOT_YET_RECRUITING
Clavicle Fracture
Assiut University
 2024-12-01 PHASE4
NCT05996133 RECRUITING
Cervical Spine Fusion
Hartford Hospital
 2023-12-12 PHASE4
NCT05750992 RECRUITING
Cesarean Section; Ultrasound Guided Transversus Abdominis Plane Block; Surgical Transversus Abdominis Plane Block; Bupivacaine; Acute Pain
Al-Azhar University
 2023-04-10
NCT07560501 NOT_YET_RECRUITING
Post Cesarean Section Pain
Tribhuvan University Teaching Hospital, Institute Of Medicine.
 2026-04-01 PHASE4
NCT07550348 RECRUITING
Lower Extremity; Nerve Block; Pain, Postoperative; Pain, Nerve
Ataturk University
 2025-12-01
NCT06677827 NOT_YET_RECRUITING
Upper Abdominal Cancer Surgery
Assiut University
 2024-12-01 PHASE4
NCT07324499 RECRUITING
Pain; Interscalene Blocks; Dexamethasone; Bupivacaine
Pontificia Universidad Catolica de Chile
 2026-05-19
NCT05131178 RECRUITING
Post-operative Pain; Cesarean Section
University of Colorado, Denver
 2021-11-07
NCT07609836 NOT_YET_RECRUITING
We Are Studying the Effects of Caudal Dexamethasone in Neonates Undergoing Inguinal Hernia Repair
Ain Shams University
 2026-05
NCT07681648 ENROLLING_BY_INVITATION
Postoperative Pain After Spinal Surgery
Engy Emil
 2026-07-26 PHASE4
NCT07794852 NOT_YET_RECRUITING
Intraoperative Hypotension; Spinal Aneshtesia; TURP(Transurethral Resection of Prostate)
Istanbul University
 2026-08-24
NCT07693621 RECRUITING
Dexmedetomidine; Magnesium Sulfate; Laparoscopic Cholecystectomy
Alexandria University
 2026-05-03
NCT07338916 RECRUITING
Brachial Plexus Blockade; Shoulder Surgery; Superficial Cervical Plexus Block
Hospital del Trabajador de Santiago
 2026-04
NCT07626346 RECRUITING
Shoulder Pain
Kasr El Aini Hospital
 2026-06-10
NCT06143306 RECRUITING
Total Shoulder Arthroplasty
University of Minnesota
 2024-08-14 PHASE4
NCT07588230 RECRUITING
Heart Valve Disease; Postoperative Pain
Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
 2026-05-16
NCT07775248 RECRUITING
Osteoarthritis (OA) of the Knee
Henry Ford Health System
 2025-02-11 PHASE4
NCT07678073 RECRUITING
Kidney Disease, End-Stage; Kidney Transplant; Kidney; Kidney Disease; Renal Transplant
University of Gaziantep
 2026-03-01
NCT06344091 RECRUITING
Local Analgesia Via Infiltration
Jiangsu HengRui Medicine Co., Ltd.
 2024-05-21 PHASE4
NCT07616180 NOT_YET_RECRUITING
TAP Block; Caesarean Section; Postoperative Pain
Cairo University
 2026-06-06 PHASE4
NCT04126824 ACTIVE_NOT_RECRUITING
Uterine Fibroids; Adenomyosis
University of California, Los Angeles
 2022-01-06 EARLY_PHASE1
NCT07027540 NOT_YET_RECRUITING
Laparoscopic Cholecystectomy
Assiut University
 2025-08-01 PHASE3
NCT06474949 NOT_YET_RECRUITING
Tibial Plateau Fractures
University of Washington
 2024-08-01 PHASE4
NCT07450781 ENROLLING_BY_INVITATION
Shoulder Pain , Laparoscopic Cholecystectomy
Alexandria University
 2026-02-01
NCT07416084 NOT_YET_RECRUITING
Hypotension After Spinal Anesthesia
Liaquat National Hospital & Medical College
 2026-02-01 PHASE2
NCT06002217 COMPLETED
Fusion of Spine, Lumbar Region
Clinique Saint Jean, France
 2024-02-05
NCT07081373 RECRUITING
Anal Fistula
Sixth Affiliated Hospital, Sun Yat-sen University
 2025-07-16
NCT07648784 RECRUITING
Epidural Dosage of Lidocaine Bupivacaine in Lower Limb Surgeries
Shaheed Mohtarma Benazir Bhutto Institue of Trauma
 2025-12-18
NCT06937385 NOT_YET_RECRUITING
Headache; Migraine; Tension Headache; Occipital Neuralgia
HCA Florida North Florida Hospital
 2025-05-01 PHASE3
NCT05193227 RECRUITING
Postoperative Pain; Postsurgical Pain
University of British Columbia
 2021-10-27 PHASE2
NCT07271979 COMPLETED
Liposomal Bupivacaine; Preperitoneal Infiltration; Analgesia
Qilu Hospital of Shandong University
 2026-01-04
NCT07094386 RECRUITING
Post Operative Pain
Cairo University
 2025-08-15
NCT06694077 NOT_YET_RECRUITING
Tonsillectomy Postoperative Adverse Events; Dexamethasone Administration; Bupivacaine
Assiut University
 2024-12-01 PHASE4
NCT07482709 RECRUITING
Post Operative Pain in Total Abdominal Hystrectomy
Liaquat National Hospital & Medical College
 2025-11-01 PHASE1; PHASE2
NCT07171931 NOT_YET_RECRUITING
Postoperative Pain Management in Total Knee Arthroplasty
Kocaeli University
 2025-09-15
NCT06545409 RECRUITING
RATS Surgery; Thymectomy; Locoregional Anesthesia; Postoperative Pain Management; Serratus Posterior Superior Intercostal Plane Block; Robotic-Assisted Thoracoscopic Surgery
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
 2025-03-01
NCT07725731 COMPLETED
Periodontal Surgery
The University of Texas Health Science Center at San Antonio
 2024-10-02 PHASE1; PHASE2
NCT07340801 COMPLETED
Analgesia
Fayoum University
 2025-11-01 PHASE4
NCT06778668 NOT_YET_RECRUITING
Postoperative Pain, Acute
Uludag University
 2025-02-10
NCT07071012 COMPLETED
Nephrectomy; Pain Scores; Paravertebral Block; External Oblique Intercostal Block
Hacettepe University
 2025-08-01
NCT06513013 COMPLETED
Cesarean Section
Assiut University
 2023-12-20 PHASE2; PHASE3
NCT06756347 NOT_YET_RECRUITING
Regional Anesthesia
Assiut University
 2025-01-01
NCT07196631 COMPLETED
Rebound Pain; Liposomal Bupivacaine
Liu Jiuhong
 2025-09-20 PHASE4
NCT07002580 RECRUITING
Patients Undergoing Arthroscopic Knee Surgery
Sakarya University
 2025-07-01
NCT05233462 RECRUITING
Regional Anesthesia Morbidity; Cesarean Section Complications; Local Anesthetic Complication
University Hospital, Caen
 2022-02-23
NCT07137208 COMPLETED
Cesarean Section Wound
Mansoura University
 2025-10-01
NCT06972485 COMPLETED
Geriatric Patient; Spinal Anesthesia; Hip Surgery
Eskisehir Osmangazi University
 2025-05-15
NCT06704698 RECRUITING
Pain Syndrome; Dizziness; Vomiting; Itching; Sweet Syndrome; Cold; Satisfaction, Patient
Zhejiang Cancer Hospital
 2024-12-03
NCT06405724 UNKNOWN
Analgesia
Feng Gao
 2024-05-10 PHASE3
NCT04232306 WITHDRAWN
Postoperative Pain; Cesarean Section
Wake Forest University Health Sciences
 2024-03 PHASE4
NCT06683807 NOT_YET_RECRUITING
Headache
Assiut University
 2024-12
NCT07460115 COMPLETED
Modified Radical Mastectomy
Gulab Devi Hospital
 2025-05-28
NCT07058194 COMPLETED
Cholecystectomy, Laparoscopic; Pain, Postoperative; Electrocardiography; Regional Anesthesia; Cardiac Electrophysiology
Harran University
 2025-07-20
NCT07556614 COMPLETED
Hip Fractures; Supra-inguinal Fascia Iliaca Block; Spinal Anesthesia
Ghurki Trust and Teaching Hospital
 2025-06-01 PHASE4
NCT06680167 COMPLETED
Spinal Anesthesia
Sohag University
 2024-10-09 EARLY_PHASE1
NCT06235606 COMPLETED
Acute Pain
The University of Hong Kong
 2024-05-08 PHASE3
NCT06656299 RECRUITING
Cholecystitis; Cholecystitis, Acute; Cholecystitis, Chronic; Cholecystitis; Gallstone
Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
 2024-10-30
NCT06069791 COMPLETED
Post-Traumatic Headache
Yale University
 2024-01-26 PHASE1
NCT06956950 RECRUITING
Pain Score Reduction
Tanta University
 2025-05 PHASE2; PHASE3
NCT05900427 TERMINATED
Total Shoulder Arthroplasty; Reverse Total Shoulder Arthroplasty
Johnny K. Lee
 2023-10-23 PHASE4
NCT07035184 NOT_YET_RECRUITING
Pediatrics; Spinal Aneshtesia; Infraumbilical Surgeries
Cairo University
 2025-08-01
NCT07349680 COMPLETED
Postherpetic Neuralgia
Assiut University
 2023-03-15 PHASE3
NCT06860893 COMPLETED
Prostate Cancer Surgery
University Hospital of North Norway
 2025-02-28 PHASE4
NCT06520475 COMPLETED
Post Operative Pain
Cairo University
 2024-08-01 PHASE3
NCT07518225 COMPLETED
Postoperative Pain; Orthognathic Surgery
Esra Beyler
 2022-09-02
NCT06575010 UNKNOWN
Rotator Cuff Tears; Postoperative Pain
Rothman Institute Orthopaedics
 2024-08-26 PHASE4
NCT06769737 NOT_YET_RECRUITING
Spinal Anesthesia Evaluation
King Abdulaziz Medical City
 2025-03-01 PHASE4
NCT06833697 COMPLETED
Breast Surgery; Erector Spinae Plane Block; Serratus Posterior Superior Intercostal Plane Block
Medipol University
 2025-01-27
NCT06252662 RECRUITING
Breast Cancer
United States Naval Medical Center, Portsmouth
 2024-10-15 PHASE4
NCT06465992 UNKNOWN
Foot Surgery; Ankle Surgery; Post Operative Pain; Popliteal Nerve Block
Rothman Institute Orthopaedics
 2024-06-17 PHASE4
NCT07149168 COMPLETED
Pain During Spinal Positioning
Ain Shams University
 2024-12-10 PHASE1
NCT06842342 COMPLETED
Sacral Erector Block Versus Pericapsular Block Versus Lumber Plexus Block
Tanta University
 2025-01-10
NCT06443619 UNKNOWN
Post-mastectomy Pain Syndrome
Mansoura University
 2024-06-04
NCT06330168 COMPLETED
Calcitonin; Paravertebral; Thoracotomy
Tanta University
 2024-03-28
NCT07046325 COMPLETED
Post Operative Pain, Acute; Arthroscopic Shoulder Surgery
Ain Shams University
 2025-01-20
NCT07734233 COMPLETED
Benign Prostatic Hyperplasia; Transurethral Resection of the Prostate (TURP)
Haseki Training and Research Hospital
 2024-10-10
NCT06570096 COMPLETED
Premixed; Sequential; Lidocaine; Bupivacaine; Supraclavicular Brachial Plexus Block; Arteriovenous Fistula
Tanta University
 2024-08-24
NCT04117074 COMPLETED
Surgery; Analgesia
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
 2021-04-14 PHASE3
NCT05794828 COMPLETED
Pain Management
The University of Texas Health Science Center at San Antonio
 2023-09-15 EARLY_PHASE1
NCT05598255 TERMINATED
Analgesic Effect
Algemeen Ziekenhuis Maria Middelares
 2022-07-01 PHASE4
NCT06145165 UNKNOWN
Liposomal Bupivacaine; Postoperative Recovery; Unilateral Knee Arthroplasty
Nanjing First Hospital, Nanjing Medical University
 2023-12-10 PHASE4
NCT06290583 COMPLETED
Spinal Anesthetics Causing Adverse Effects in Therapeutic Use
South Valley University
 2024-04-21
NCT05536063 UNKNOWN
Pediatric Cardiac Surgery
Assiut University
 2023-05
NCT05720949 COMPLETED
ACL; Anterior Cruciate Ligament Injuries
Hospital for Special Surgery, New York
 2023-01-12 PHASE4
NCT06331182 COMPLETED
Dexmedetomidine; Ketamine; External Oblique Intercostal Plane Block; Post Thoracotomy Pain
Tanta University
 2024-03-26
NCT06834841 UNKNOWN
Post Spinal Shivering
Ain Shams University
 2024-04-01
NCT06501079 UNKNOWN
Renal Neoplasm
National Cancer Institute, Egypt
 2024-05-01
NCT06006624 UNKNOWN
ACL; Postoperative Pain
Rothman Institute Orthopaedics
 2023-08-21 PHASE4
NCT04189783 ACTIVE_NOT_RECRUITING
Retroperitoneal Sarcoma
M.D. Anderson Cancer Center
 2020-06-08 PHASE2
NCT06646172 RECRUITING
Median Sternotomy
Tongji Hospital
 2024-10-24
NCT06766474 COMPLETED
Skin Graft Complications; Pain Management
Minia University
 2023-03-01 PHASE2
NCT06847620 COMPLETED
Hand Surgery
Ain Shams University
 2024-03-01 PHASE4
NCT06482229 COMPLETED
Regional Anesthesia Morbidity
Sivas State Hospital
 2024-07-01
NCT06483581 UNKNOWN
Post Operative Pain
Cumhuriyet University
 2024-07
NCT06557018 UNKNOWN
Osteoarthritis, Knee
Dezhou Hospital Qilu Hospital of Shandong University
 2024-06-25 PHASE4
NCT06847425 COMPLETED
Anaesthesia
Ain Shams University
 2024-03-20
NCT06689358 COMPLETED
Pain, Postoperative
King Hussein Cancer Center
 2022-11-01
NCT05958589 COMPLETED
Postoperative Pain
University of Novi Sad
 2022-01-08 PHASE3
NCT05017246 TERMINATED
Cancer Debulking; Enlarged Uterus; Fibroid Uterus; Adnexal Mass
Washington University School of Medicine
 2022-01-18 PHASE2
NCT03434678 COMPLETED
Pancreatic Cancer
Memorial Sloan Kettering Cancer Center
 2018-01-30 PHASE3
NCT07058493 COMPLETED
Knee Surgeries
Cairo University
 2024-01-02
NCT06386783 UNKNOWN
Dexmedetomidine; Fentanyl
Aswan University
 2023-07-01 PHASE3
NCT06702202 COMPLETED
Peripheral Arterial Disease; Subarachnoid Block; Femoropopliteal Block; Tissue Oxygen Saturation
Indonesia University
 2024-01-01
NCT06541613 COMPLETED
External Oblique Intercostal Plane Block; Laparoscopic Cholecystectomy
Theodor Bilharz Research Institute
 2024-04-25 PHASE4
NCT03599635 COMPLETED
Acute Pain
University of Minnesota
 2018-07-01 PHASE4
NCT05845125 TERMINATED
Shoulder Pain
Claire Bourgeois
 2023-05-21 PHASE4
NCT06301503 COMPLETED
Lower Extremity Surgery
Udayana University
 2024-03-09 PHASE3
NCT05666076 COMPLETED
Orthopedic Disorder; Shoulder Pain; Surgery; Analgesia
Bakirkoy Dr. Sadi Konuk Research and Training Hospital
 2024-01-02
NCT06137924 UNKNOWN
Pain, Postoperative; Nausea, Postoperative; Vomiting, Postoperative; Analgesia; Opioid Use
Universidad Simón Bolívar
 2023-12-02 PHASE3
NCT06020781 COMPLETED
Dexmedetomidine; Bupivacaine; Supraclavicular Brachial Plexus Block
Kafrelsheikh University
 2023-10-09
NCT06046105 UNKNOWN
Postoperative Pain, Acute
Ain Shams University
 2023-09-15 PHASE2; PHASE3
NCT05751421 UNKNOWN
Pain, Postoperative
Rothman Institute Orthopaedics
 2023-02-28 PHASE3
NCT05707169 UNKNOWN
Varicose Veins; Venous Reflux; Venous Insufficiency; Venous Leg Ulcer
Mansoura University
 2023-01-04
NCT06292273 COMPLETED
Post Operative Pain
Menoufia University
 2023-10-10
NCT06011746 COMPLETED
Ketamine; Levobupivacaine; Paravertebral Block; Acute Pain; Chronic Pain
Tanta University
 2023-08-30 PHASE4
NCT04559347 TERMINATED
Thoracic Surgery
Poovendran Saththasivam
 2020-12-10 PHASE2
NCT05495750 COMPLETED
Perioperative Inflammatory Response; Postoperative Pain
Alaa Mohamed Abdel Salam Ibrahim Soliman
 2022-06-24 PHASE4
NCT06619080 COMPLETED
Osteoarthritis, Knee/Rehabilitation
Hospital Universitario Fundación Alcorcón
 2023-04-26
NCT05261672 UNKNOWN
Postoperative Pain
Assiut University
 2022-03-15
NCT05717114 COMPLETED
Post Operative Pain
Menoufia University
 2023-02-05
NCT06166602 COMPLETED
Regional Anesthesia; Postoperative Pain; Hip Surgery
Istanbul Medeniyet University
 2023-07-30
NCT05663801 COMPLETED
Cancer; Breast
Beni-Suef University
 2022-12-01 PHASE2
NCT05374499 COMPLETED
Post Operative Pain
University of Southern California
 2022-09-01 PHASE4
NCT05687981 UNKNOWN
Hernia, Inguinal
Tanta University
 2023-01 EARLY_PHASE1
NCT04867369 COMPLETED
Tendonitis
NYU Langone Health
 2021-07-14 PHASE4
NCT04640896 COMPLETED
Myofacial Pain; Pain, Neck; Pain, Back; Cervical Fusion
George Washington University
 2020-11-05 PHASE4
NCT05351489 COMPLETED
Transurethral Resection of Prostate
Mansoura University
 2022-05-30 EARLY_PHASE1
NCT04345341 COMPLETED
the Efficacy of Analgesia of Laparoscopic TAP Block in Minimally Invasive Gynecology Surgeries
Yale University
 2020-11-01 PHASE2
NCT05855798 COMPLETED
Postoperative Analgesia
Cukurova University
 2023-05-10 PHASE4
NCT06135545 WITHDRAWN
Lung Cancer
Shiyou Wei
 2023-10-01
NCT05708742 COMPLETED
Pain; Ankle Injuries
Fayoum University Hospital
 2023-01-01
NCT06003933 COMPLETED
Post Operative Pain; Cervical Spine Instability
Yasser S Mostafa, MD
 2023-03-03
NCT05532618 COMPLETED
Anterior Cruciate Ligament Injuries
St. Antonius Hospital
 2022-08-01
NCT04471597 COMPLETED
Thyroid Diseases
Zagazig University
 2020-07-20
NCT05767749 COMPLETED
Anesthetics, Local
Weill Medical College of Cornell University
 2023-03-14 PHASE4
NCT05289323 COMPLETED
Post-Dural Puncture Headache
Alexandria University
 2022-04-25 PHASE4
NCT02689024 TERMINATED
Hip Fractures; Anesthesia
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
 2016-05 PHASE4
NCT05074823 COMPLETED
Ketamine Causing Adverse Effects in Therapeutic Use
Assiut University
 2022-02-26 PHASE4
NCT05196256 UNKNOWN
Obstetric Pain; Analgesia
Brugmann University Hospital
 2022-06-30 PHASE3
NCT07176299 COMPLETED
Cholelithiasis; Cholecystectomy, Laparoscopic; Pain, Postoperative; Anesthesia, Local; Nerve Block
University of Warmia and Mazury in Olsztyn
 2021-09-14
NCT07689617 COMPLETED
Drug-Resistant Epilepsy; Epilepsy; Vagus Nerve Stimulation
Firat University
 2022-05-01
NCT05727098 COMPLETED
Breast Cancer
National Cancer Institute, Egypt
 2023-01-01 PHASE2; PHASE3
NCT04826484 TERMINATED
Urologic Diseases; Hypospadias; Undescended Testes; Chordee; Hydrocele; Orchiectomy
Johns Hopkins University
 2021-10-01 PHASE3
NCT06293807 COMPLETED
Periodontal Diseases
The University of Texas Health Science Center at San Antonio
 2022-06-06 EARLY_PHASE1
NCT04551833 UNKNOWN
Regional Anesthesia
Assiut University
 2021-04-01 PHASE4
NCT05526469 COMPLETED
Congenital Heart Disease
Ain Shams University
 2022-07-24
NCT04074226 TERMINATED
Postoperative Pain
University of Texas Southwestern Medical Center
 2021-03-20
NCT05905757 COMPLETED
Transversus Abdominis Plane Block
Yuzuncu Yil University
 2022-03-01
NCT05550597 COMPLETED
Postoperative Pain; Cesarean Section
Nepal Mediciti Hospital
 2022-08-15
NCT06531603 COMPLETED
Post Operative Pain; Bradycardia; Hypotension; Nausea; Vomiting
Sahiwal medical college sahiwal
 2022-02-20 PHASE2; PHASE3
NCT04849858 TERMINATED
Ovarian Cancer; Fibroids; Uterine Cancer
University of California, Irvine
 2019-05-20 PHASE3
NCT03638960 COMPLETED
Shoulder Pain; Postoperative Pain
University of Southern California
 2019-02-21 PHASE4
NCT06085417 COMPLETED
Bupivacaine; Dexamethasone; Magnesıum Sulphate; Adjuvant
Yuzuncu Yil University
 2023-01-02
NCT05342844 COMPLETED
Analgesia
Mansoura University
 2022-05-01
NCT07208253 COMPLETED
Inguinal Hernia Repair (Not Urgent)
Gürkan Değirmencioğlu
 2021-04-01
NCT03413371 COMPLETED
Vitreoretinal Surgeries; Postoperative Nausea and Vomiting; Postoperative Pain; Oculocardiac Reflex
Medical University of Silesia
 2018-04-26
NCT05813158 COMPLETED
Comparing of 2 Different Volumes in ESPB in Patients Undergoing MRM
Cairo University
 2022-09-09 PHASE2; PHASE3
NCT04613830 COMPLETED
Pediatric Cancer
Assiut University
 2020-11-20 PHASE3
NCT05369468 COMPLETED
Dexmedtomidine in Erector Spinae Block for Laparscopic Cholecystectomy
Tanta University
 2020-01-22 PHASE1; PHASE2
NCT05361642 UNKNOWN
Drug Use
Ain Shams University
 2022-02-03
NCT04167176 COMPLETED
Postoperative Pain
Assiut University
 2020-09-15
NCT05082441 UNKNOWN
Benign Neoplasm
Samaritan Health Services
 2020-09-01 PHASE4
NCT03115151 TERMINATED
Pain
University of Texas Southwestern Medical Center
 2017-05-08 PHASE4
NCT04938037 COMPLETED
Chronic Shoulder Pain
TC Erciyes University
 2021-06-01
NCT05069350 COMPLETED
Pain, Acute
Research Institute of Ophthalmology, Egypt
 2021-09-01 EARLY_PHASE1
NCT04152564 COMPLETED
Abdominal Cancer
South Egypt Cancer Institute
 2018-10-29
NCT04479371 WITHDRAWN
Hypospadias
University of Texas Southwestern Medical Center
 2021-07 PHASE1
NCT04565301 COMPLETED
Pain, Postoperative
Cairo University
 2021-06-20
NCT06109415 COMPLETED
Postoperative Pain; Total Shoulder Arthroplasty; Multimodal Analgesia
Heron Therapeutics
 2021-10-20 PHASE4
NCT04920994 COMPLETED
Abdominal Surgery
Sameh Fathy
 2021-08-13
NCT04461028 WITHDRAWN
Rotator Cuff Tears
University of Pennsylvania
 2019-02-21 PHASE3
NCT04751344 UNKNOWN
Liposomal Bupivacaine; Postoperative Pain; Forefoot Surgery; Opioid Use; Bunion
Alexandra Black
 2020-06-16 PHASE4
NCT04998071 UNKNOWN
Postoperative Pain
Queen Sirikit National Institute of Child Health
 2021-08-15
NCT05118620 WITHDRAWN
Hip Arthropathy; Postoperative Pain, Acute; Pain, Postoperative
University of California, San Diego
 2021-12-09 PHASE4
NCT05133687 COMPLETED
Anesthesia, Caudal; Pediatrics
Kasr El Aini Hospital
 2021-11-15 PHASE3
NCT03672500 TERMINATED
Second Degree Perineal Tear During Delivery - Delivered; Episiotomy; Complications; Anesthesia, Local
Sunnybrook Health Sciences Centre
 2018-09-14
NCT04782778 COMPLETED
Anesthesia, Local; Postoperative Pain
Istanbul University
 2021-04-01
NCT04974385 COMPLETED
Analgesia
University of Virginia
 2021-08-04 PHASE3
NCT06735443 COMPLETED
Hemodynamic Stability; Post Operative Pain; Inguinal Hernia Repair
Sahiwal medical college sahiwal
 2021-03-06 PHASE2; PHASE3
NCT04275661 COMPLETED
Analgesia; Breast Cancer
Assiut University
 2020-08-01 PHASE2
NCT03248791 UNKNOWN
Cesarean Section Complications; Spinal Anesthesia
Cairo University
 2017-08-20 PHASE4
NCT04733560 UNKNOWN
Pelvic Organ Prolapse
Fraser Health
 2021-04-01
NCT04865211 UNKNOWN
Pain, Postoperative
The Cooper Health System
 2021-04-05 PHASE2
NCT04727229 COMPLETED
Treatment Resistant Depression; Major Depressive Disorder
Unity Health Toronto
 2021-09-23 PHASE4
NCT04204343 COMPLETED
Anesthesia, Local
Istanbul University
 2019-01-01
NCT05184465 COMPLETED
Anesthesia, Spinal
Mogilev Regional Clinical Hospital
 2017-12-18
NCT03738696 COMPLETED
Rotator Cuff Injury
University of Alabama at Birmingham
 2019-12-15 PHASE4
NCT04791475 COMPLETED
Brachial Plexus Block; Dexmedetomidine; Dexamethasone; Bupivacaine
Tribhuvan University Teaching Hospital, Institute Of Medicine.
 2021-02-22
NCT04786756 COMPLETED
Anesthesia, Local; Postoperative Pain
Istanbul University
 2020-01-01
NCT04773301 COMPLETED
Hip Fractures
Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
 2021-02-13 PHASE4
NCT04540848 WITHDRAWN
Post Operative Pain
The University of Texas Health Science Center, Houston
 2021-03-01 PHASE4
NCT04920669 COMPLETED
Postoperative Pain
Mohamed Elsayed Hassan
 2021-07-01
NCT04082676 COMPLETED
Maternal Hypotension After Spinal Anesthesia
B.P. Koirala Institute of Health Sciences
 2019-11-30 PHASE4
NCT05225766 COMPLETED
Postoperative Pain, Acute
Uludag University
 2021-02-25
NCT04799184 COMPLETED
Anesthetics Complications; Anesthetic Toxicity; Bupivacaine Overdose; Nerve Block; Surgery
Pontificia Universidad Catolica de Chile
 2019-04-03 PHASE4
NCT04928521 COMPLETED
Cardiac Surgery; Postoperative Pain
Ankara City Hospital Bilkent
 2021-06-01
NCT03975283 UNKNOWN
Post Operative Pain
McMaster University
 2019-08 PHASE4
NCT04821947 UNKNOWN
Anesthesia
Ain Shams University
 2021-04-01
NCT04903743 UNKNOWN
Diabetic Patient
Alexandria University
 2021-01-10
NCT04033562 TERMINATED
Opioid-use Disorder; Opioid Use; Opioid Dependence; Opioid Abuse; Medication Assisted Treatment; Infusion Catheter, Wound; Lidopatch; Ambu ACTion; Pregnancy Related; Cesarean Section
WellSpan Health
 2020-01-15 PHASE4
NCT04782960 UNKNOWN
Anesthesia, Local
Fayoum University
 2021-04
NCT04720287 COMPLETED
Postoperative Analgesia
Ain Shams University
 2021-02-01 PHASE4
NCT03174782 TERMINATED
Postoperative Pain
University of California, San Francisco
 2018-01-01 PHASE4
NCT03607227 COMPLETED
Head and Neck Cancer; Pain, Musculoskeletal
Region Skane
 2018-09-01 PHASE4
NCT04047446 COMPLETED
Shoulder Pain
Hospital for Special Surgery, New York
 2019-07-11 PHASE4
NCT04221568 UNKNOWN
Labor Pain
Assiut University
 2020-03-01 PHASE1
NCT04618146 UNKNOWN
Pain, Postoperative; Pruritus; Nausea, Postoperative; Vomiting, Postoperative
Minia University
 2020-11-10
NCT04718259 COMPLETED
Analgesia; Children, Only; Bupivacaine; Midazolam
Tanta University
 2020-01-18 EARLY_PHASE1
NCT04544228 COMPLETED
Postoperative Pain
Cairo University
 2020-09-05
NCT04116554 COMPLETED
Analgesia
Fayoum University
 2019-12-27 PHASE4
NCT04508894 COMPLETED
Supraclavicular Brachial Plexus Block
Minia University
 2019-04-21
NCT04173611 TERMINATED
Healthy
Pacira Pharmaceuticals, Inc
 2020-06-08 PHASE1
NCT03388671 UNKNOWN
Analgesia
Assiut University
 2017-12-25 PHASE2; PHASE3
NCT04065919 UNKNOWN
Cardiothoracic Surgery
Florida Heart and Lung Institute
 2019-10-01 PHASE4
NCT04113720 COMPLETED
Post-tonsillectomy Analgesia; Levobupivacaine
Assiut University
 2019-11-15 PHASE1; PHASE2
NCT03729375 COMPLETED
Pain, Postoperative; Carpal Tunnel Syndrome
University of South Florida
 2018-10-04 PHASE1
NCT04443634 UNKNOWN
Postoperative Pain
Cairo University
 2020-06-25
NCT03954639 WITHDRAWN
Bunion; Metatarsophalangeal Fusion; Midfoot Fusion; Hindfoot Fusion; Total Ankle Arthroplasty; Forefoot Surgery
Pacira Pharmaceuticals, Inc
 2020-06-15 PHASE3
NCT03574376 UNKNOWN
Trauma; Trauma Injury; Pain, Acute
Chadrick Evans
 2018-08-29 PHASE4
NCT04313764 UNKNOWN
Colorectal Cancer; Postoperative Pain
Ataturk University
 2020-06-18
NCT03305666 COMPLETED
Drug Effect; Rib Fractures; Rib Trauma; Surgical Procedure, Unspecified; Pain; Catheter (Other); Nerve Pain; Local Infiltration; Anesthesia, Local; Intercostal Rib; Opioid Dependence; Chest Injury Trauma; Pneumonia
Denver Health and Hospital Authority
 2017-10-05 PHASE4
NCT04244097 COMPLETED
Pain, Postoperative
Kasr El Aini Hospital
 2020-04-10 PHASE2
NCT04790292 COMPLETED
Anesthesia
Ain Shams University
 2020-01-01 PHASE4
NCT03109691 UNKNOWN
Bilateral Superficial Cervical Block
Assiut University
 2018-01-28
NCT04368364 TERMINATED
Pain, Postoperative
The University of Texas Health Science Center, Houston
 2020-05-22 PHASE4
NCT04232904 UNKNOWN
Liver Transplant; Complications; Inflammatory Response
Inonu University
 2019-12-02 PHASE4
NCT02752230 WITHDRAWN
Post Operative Pain
Kettering Health Network
 2016-11-29 PHASE4
NCT03388814 WITHDRAWN
Pain, Postoperative; Breast Cancer; Opioid Use; Surgery
Wake Forest University Health Sciences
 2018-11 EARLY_PHASE1
NCT03395912 COMPLETED
Cesarean Section
HaEmek Medical Center, Israel
 2018-01-25
NCT04254523 COMPLETED
Analgesia, Epidural; Pain, Postoperative
CHU de Quebec-Universite Laval
 2019-11-14
NCT04670497 COMPLETED
Regional Anesthesia
Menoufia University
 2018-07-01
NCT03638011 TERMINATED
Caesarean Section
Maimonides Medical Center
 2018-09-25 PHASE4
NCT03702621 COMPLETED
Colorectal Surgery
Indiana University
 2018-08-30 PHASE3
NCT02818894 TERMINATED
Total Hip Arthroplasty
Thomas L Bradbury
 2016-09-27 PHASE4
NCT03070054 COMPLETED
Pain
University of Utah
 2016-06 EARLY_PHASE1
NCT03797079 COMPLETED
Chest Trauma
Sameh Fathy
 2019-01-20
NCT05158647 COMPLETED
Magnesium Sulfate Causing Adverse Effects in Therapeutic Use
Abdelrady S Ibrahim, MD
 2018-08-12 PHASE2
NCT02862912 COMPLETED
Adverse Reaction to Spinal Anesthetic; Maternal Care for Cervical Incompetence
Columbia University
 2016-11-08 PHASE4
NCT02277782 TERMINATED
Pregnancy
Brigham and Women's Hospital
 2015-09-01
NCT03427502 COMPLETED
Postoperative Agitation: Impaired Awareness, Abnormal Cognitive Function, Confusion, and Verbal and Physical Agitation During Recovery From General Anesthesia; Deviated Nasal Septum; Chronic Rhinosinusitis (Diagnosis); Nasal Polyps
Lumbini Medical College
 2018-06-01
NCT02618876 COMPLETED
Postoperative Pain
Assiut University
 2015-11
NCT03862287 UNKNOWN
Orthopedic Disorder; Leg Injuries
McGill University Health Centre/Research Institute of the McGill University Health Centre
 2018-11-01
NCT02863120 COMPLETED
Knee Osteoarthritis
Texas Orthopaedics, Sports and Rehabilitation Associates
 2016-07 PHASE4
NCT03335293 WITHDRAWN
Pregnancy; Cesarean Section
University of Florida
 2019-10 PHASE4
NCT04037774 UNKNOWN
Drug Effect
Services Institute of Medical Sciences, Pakistan
 2019-09-02 PHASE4
NCT03735771 COMPLETED
Labor Pain
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
 2018-12-03
NCT03706313 COMPLETED
Post-operative Pain
Duke University
 2019-01-15 PHASE4
NCT03708198 COMPLETED
Thoracic
University of Virginia
 2018-06-11 PHASE4
NCT04036201 COMPLETED
Peribulbar Block
Ain Shams University
 2019-07-31
NCT03434951 UNKNOWN
Pain, Postoperative
South Carelia Central Hospital
 2017-11-06 PHASE4
NCT03926663 UNKNOWN
Intranasal Dexmedetomidine; Intranasal Bupivacaine; Septoplasty Surgeries
Cairo University
 2019-07-20 PHASE4
NCT03619785 UNKNOWN
Rib Fractures; Rib Fracture Multiple
Andrew A Herring
 2018-11-06 PHASE4
NCT03155646 COMPLETED
Transversus Abdominis Plane Block
Assiut University
 2017-06-10 PHASE2; PHASE3
NCT03865147 UNKNOWN
Wounds Injuries; Anesthesia, Local
Medical Ethics UK Ltd
 2019-01-15 PHASE2
NCT03899038 COMPLETED
Lower Limb Surgery
Huazhong University of Science and Technology
 2019-04-08
NCT03103100 COMPLETED
Labor Pain
University of Alabama at Birmingham
 2015-10-08 PHASE3
NCT02682082 TERMINATED
Pancreatic Cancer
Centre hospitalier de l'Université de Montréal (CHUM)
 2016-05-27
NCT03867188 TERMINATED
Soft Tissue Sarcoma; Soft Tissue Tumor; Soft Tissue Tumor and/or Sarcoma
Wake Forest University Health Sciences
 2019-01-14 EARLY_PHASE1
NCT05444036 COMPLETED
Surgery; Pediatric Surgery
Egymedicalpedia
 2018-09-01 PHASE1
NCT02995291 COMPLETED
Anesthesia, Local
Dalhousie University
 2017-02-10 PHASE4
NCT03830086 COMPLETED
Postoperative Pain; Anesthesia
IRCCS Azienda Ospedaliero-Universitaria di Bologna
 2019-02-07
NCT03792906 COMPLETED
Cesarean Section Complications; Spinal Anesthetic Toxicity
Cairo University
 2019-01-18 PHASE4
NCT02315573 COMPLETED
Carpal Tunnel Syndrome
St. Mary's Research Center, Canada
 2014-10
NCT03701126 UNKNOWN
Anesthesia
Zagazig University
 2018-11-01
NCT03023982 UNKNOWN
Anesthesia; Surgery; Block; Thoracic Injury
Soroka University Medical Center
 2017-02 PHASE2
NCT03250507 COMPLETED
Hysterectomy
Henry Ford Health System
 2017-03-13 PHASE4
NCT03401450 COMPLETED
ACL Surgery
NYU Langone Health
 2018-02-01 PHASE4
NCT03182114 UNKNOWN
Cesarean Section Complications
Cairo University
 2017-06-12 PHASE4
NCT04000100 COMPLETED
Postoperative Pain
ABEER HASSANIN
 2018-07-15
NCT02858622 COMPLETED
Renal Failure
Cairo University
 2016-12
NCT03623230 COMPLETED
Anesthesia, Conduction; Arthroplasty, Replacement, Knee; Pain, Postoperative; Anesthesia and Analgesia
Bozyaka Training and Research Hospital
 2018-08-10 PHASE4
NCT03602469 UNKNOWN
Arthroscopic Shoulder Surgery
Mansoura University
 2018-07
NCT02973048 COMPLETED
Pregnant Women; Pain; Hypotension
Centre Hospitalier Universitaire Saint Pierre
 2018-03-12 PHASE3
NCT03234816 COMPLETED
Cesarean Section Complications
Cairo University
 2017-08-02 PHASE4
NCT02988700 COMPLETED
Pain, Postoperative
Assiut University
 2016-11 PHASE2; PHASE3
NCT03538496 COMPLETED
Postoperative Pain
Ataturk University
 2017-12-01
NCT03512990 UNKNOWN
Brachial Plexus Block; Shoulder Surgery
Federal University of São Paulo
 2018-04-09
NCT03024957 UNKNOWN
Immune System Suppression
Assiut University
 2017-01 PHASE1; PHASE2
NCT03156296 COMPLETED
Laparoscopic Orcheopexy
Assiut University
 2017-06-10 PHASE2
NCT03373591 COMPLETED
Bariatric Surgery Analgesia
Montefiore Medical Center
 2018-01-30 PHASE2
NCT03303794 TERMINATED
Anesthesia
Montefiore Medical Center
 2017-10-25 PHASE3
NCT03261193 TERMINATED
Pain, Postoperative
Nicholas Schott
 2017-09-05 PHASE3
NCT03265886 COMPLETED
Surgery to the Distal One Third of the Upper Limb
Mansoura University
 2017-10-01
NCT03094663 COMPLETED
Knee Arthropathy
Hospital for Special Surgery, New York
 2017-02-28 PHASE4
NCT02875015 COMPLETED
Postoperative Pain
Atlantic Health System
 2016-04
NCT03372486 COMPLETED
Upper Extremity Trauma
Mansoura University
 2017-12-18
NCT03470363 COMPLETED
Knee Surgery With Tourniquet
University of Liege
 2016-01-01
NCT03692546 COMPLETED
Rotator Cuff Tear; Postoperative Pain
Orthopaedic & Neurosurgery Specialists
 2017-02-01
NCT03007966 COMPLETED
Nerve Block; Herniorrhaphy; Regional Anesthesia
Wake Forest University Health Sciences
 2017-01-30 PHASE2
NCT03011333 COMPLETED
Postoperative Pain
Heron Therapeutics
 2017-01-14 PHASE2
NCT03316352 COMPLETED
Anesthesia, Spinal; Ultrasonography
Seoul National University Hospital
 2017-10-24
NCT02665273 COMPLETED
Migraine
Montefiore Medical Center
 2015-07-01 PHASE3
NCT02726620 COMPLETED
Hypotension
Vanderbilt University Medical Center
 2017-01-05
NCT02521831 WITHDRAWN
Inguinal Hernia
Emmett Whitaker, M.D.
 2015-10 PHASE3
NCT03159000 WITHDRAWN
Migraine
Thomas Jefferson University
 2017-05-01 PHASE4
NCT02159807 COMPLETED
Pregnancy
St. Luke's-Roosevelt Hospital Center
 2015-04-24
NCT02698228 WITHDRAWN
Lower Limb Injuries; Fracture
Epicentre
 2016-03 PHASE4
NCT03155568 UNKNOWN
Anesthesia, Regional
Assiut University
 2017-06-15
NCT02674113 WITHDRAWN
Femoroacetabular Impingement
University of Missouri-Columbia
 2015-10
NCT02462148 COMPLETED
Osteoarthritis, Knee
Wake Forest University Health Sciences
 2015-07 PHASE4
NCT02621255 COMPLETED
Closed Fracture of Hip
Cukurova University
 2015-11 PHASE4
NCT02336529 UNKNOWN
Pain; Neuropathic Pain; Breast Cancer
Kenneth Geving Andersen
 2016-07 PHASE3
NCT03039426 COMPLETED
Cesarean Delivery
Department of Medical Services Ministry of Public Health of Thailand
 2017-01-01 PHASE4
NCT02713178 COMPLETED
Pain
Pacira Pharmaceuticals, Inc
 2016-06-03 PHASE3
NCT02574520 COMPLETED
Post Operative Pain
Durect
 2015-11 PHASE3
NCT02783586 COMPLETED
Postoperative Pain
Medical University of Warsaw
 2016-04-08 PHASE4
NCT02414373 COMPLETED
Post Operative Urinary Retention
Insel Gruppe AG, University Hospital Bern
 2015-04 PHASE4
NCT02982889 COMPLETED
Acute Pain
Liquidia Technologies, Inc.
 2016-12-05 PHASE1
NCT02947178 COMPLETED
Hip Pain Chronic; Anesthesia; Bupivacaine
Walter Reed National Military Medical Center
 2016-03-01 PHASE4
NCT02504580 COMPLETED
Postoperative Pain
Heron Therapeutics
 2015-07 PHASE2
NCT03067740 UNKNOWN
Pain, Postoperative
Zagazig University
 2016-06 PHASE4
NCT03072329 COMPLETED
Penile Surgery
Hôpital d'enfants Béchir-Hamza
 2016-10
NCT02762929 COMPLETED
Postoperative Pain; Bunions
Heron Therapeutics
 2016-05 PHASE2
NCT02758405 COMPLETED
Labor Pain
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
 2016-05
NCT02469610 COMPLETED
Chest Pain; Surgery
Carmel Medical Center
 2015-06 PHASE4
NCT02777866 UNKNOWN
Surgical Site Infection; Wound Infection; Postoperative Pain; Local Anesthetics
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
 2016-05
NCT02658760 UNKNOWN
Femoral Fractures
Hamidreza Mahboobi
 2015-06 PHASE3
NCT02879435 UNKNOWN
Labor Pain
Mark Kosanovich
 2016-06
NCT03230227 COMPLETED
Postoperative Pain
Assiut University
 2015-02
NCT03007927 COMPLETED
Pain, Postoperative
SEBASTIAN ROCHE
 2016-08 PHASE4
NCT02927379 COMPLETED
Abdominal Cancer
Assiut University
 2016-06 PHASE3
NCT02274870 COMPLETED
Post-operative Pain
Northwell Health
 2014-11 PHASE4
NCT02740192 COMPLETED
Pain
Henry Ford Health System
 2016-04 EARLY_PHASE1
NCT02737813 COMPLETED
Cardiac Output; Hypotension; Anesthesia, Spinal
Mahidol University
 2016-03-29 PHASE4
NCT02525718 COMPLETED
Breast Cancer
Northwestern University
 2015-08 PHASE2
NCT02393664 UNKNOWN
Lung Neoplasms
National Taiwan University Hospital
 2015-03 PHASE2; PHASE3
NCT02800694 UNKNOWN
Labour Analgesia
Minia University
 2016-07
NCT02892500 TERMINATED
Ankle Injuries
Sanford Health
 2016-04 PHASE2
NCT03415087 COMPLETED
Elective Caesarean Section
Ain Shams University
 2016-01-01
NCT03346993 COMPLETED
Effect Increased
Erzurum Palandöken State Hospital
 2016-07-01 PHASE1
NCT02223364 COMPLETED
Total Knee Arthroplasty
Mayo Clinic
 2014-07 PHASE4
NCT02480621 COMPLETED
Ankle Fracture
Jamaica Hospital Medical Center
 2014-12 PHASE3
NCT02851394 COMPLETED
Heart Surgery Via Sternotomy; Post-operative Analgesia
Centre Hospitalier Universitaire Dijon
 2015-10 PHASE4
NCT02802683 COMPLETED
Hypotension
Seoul National University Hospital
 2015-09 PHASE4
NCT02510287 COMPLETED
Labor Pain
Fundación Santa Fe de Bogota
 2015-07
NCT02369510 COMPLETED
Spinal Anesthesia; Cesarean Section
Icahn School of Medicine at Mount Sinai
 2015-02 PHASE4
NCT02112006 COMPLETED
Hand Injury; Wrist Injury; Finger Injury
Jose Soberon, MD
 2014-04
NCT02368054 COMPLETED
Cervical Intraepithelial Neoplasia
Helse Fonna
 2015-05 PHASE4
NCT02752971 COMPLETED
Postoperative Pain
Hospital Central Dr. Luis Ortega
 2015-02 PHASE3
NCT02790099 COMPLETED
Pain
Queen Mary Hospital, Hong Kong
 2014-09 PHASE4
NCT02517905 COMPLETED
Dental Pain
Pacira Pharmaceuticals, Inc
 2015-08 PHASE3
NCT02625506 COMPLETED
Breast Cancer; Radical Mastectomy Surgery
Mansoura University
 2012-06-01
NCT01751347 COMPLETED
Carpal Tunnel Syndrome; Trigger Finger
University of British Columbia
 2013-02 PHASE4
NCT01902108 COMPLETED
Post-operative Pain
St Joseph University, Beirut, Lebanon
 2013-01 PHASE4
NCT01566838 COMPLETED
Postoperative Pain
Inova Health Care Services
 2012-10
NCT00819962 UNKNOWN
Postoperative Pain
King Saud University
 2014-09 EARLY_PHASE1
NCT02620566 COMPLETED
Anesthesia
University Clinic for Anesthesia Reanimation and Intensive Care Mother Theresa
 2015-09 PHASE1; PHASE2
NCT02346110 COMPLETED
Arthrosis, Unspecified, Ankle and Foot
University of Aarhus
 2015-04 PHASE4
NCT02141178 WITHDRAWN
Pain After Carpal Tunnel Release
University of Pittsburgh
 2015-05
NCT02285491 COMPLETED
Postoperative Cesarean Delivery Pain
Ain Shams Maternity Hospital
 2014-11 EARLY_PHASE1
NCT02801188 COMPLETED
Fracture of Proximal Femur
Mansoura University
 2014-10-01
NCT04196946 COMPLETED
Anesthesia; Analgesia
Nigde Omer Halisdemir University
 2013-09-02
NCT02331563 WITHDRAWN
Postoperative Nausea and Vomiting
Kırıkkale University
 2014-10 PHASE3
NCT02064530 COMPLETED
Pain
TC Erciyes University
 2014-02 PHASE4
NCT02728323 TERMINATED
Pain
Emiliano Petrucci
 2013-10 PHASE3
NCT02397330 UNKNOWN
Regional Anesthesia; Interscalene Block; Shoulder Surgery
Tunisian Military Hospital
 2015-04
NCT02808728 UNKNOWN
Osteoarthritis; Total Knee Arthroplasty; Pain Management
DeClaire LaMacchia Orthopaedic Institute
 2014-05 PHASE4
NCT02752308 COMPLETED
Hypospadias
Isfahan University of Medical Sciences
 2014-09 PHASE2; PHASE3
NCT02232178 COMPLETED
Hernioplasty
Innocoll
 2014-10-20 PHASE2
NCT02031510 COMPLETED
Elective Laparoscopic Cholecystectomy
Imam Abdulrahman Bin Faisal University
 2014-01 PHASE1; PHASE2
NCT02026050 COMPLETED
Postoperative Pain
TC Erciyes University
 2014-01 PHASE4
NCT01960543 COMPLETED
Complication of Anesthesia
Corporacion Parc Tauli
 2013-10 PHASE4
NCT01812044 COMPLETED
Strabismus
Duke University
 2013-03
NCT02289079 COMPLETED
Acute Pain
University of Minnesota
 2013-06 PHASE4
NCT01632709 COMPLETED
Amputation Stumps; Neuroma
Shirley Ryan AbilityLab
 2012-05 PHASE4
NCT02004899 COMPLETED
Anesthetic, Sedative or Analgesic Complications in Labor or Delivery
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
 2013-12 PHASE3
NCT02037802 COMPLETED
Renal Failure
Cairo University
 2014-03
NCT01874236 TERMINATED
SI Joint Pain
SI-BONE, Inc.
 2013-04-22 PHASE4
NCT01734161 COMPLETED
Postoperative Nausea and Vomiting
Weill Medical College of Cornell University
 2012-11 PHASE4
NCT02728310 TERMINATED
Pain
San Salvatore Hospital of L'Aquila
 2012-09 PHASE3
NCT02116842 UNKNOWN
Pregnancy; Labour; Primigravida Labour; Epidural Block
University of Leeds
 2012-12 PHASE4
NCT01786655 COMPLETED
Safety of Neosaxitoxin in Healthy Volunteers
Charles Berde
 2013-05 PHASE1
NCT01960595 UNKNOWN
Pain
Kaohsiung Medical University Chung-Ho Memorial Hospital
 2013-08 PHASE4
NCT02244086 COMPLETED
Obstetric Pain
Coordinación de Investigación en Salud, Mexico
 2013-06 PHASE4
NCT01701115 COMPLETED
Shoulder Arthroscopy; Interscalene Block
Hospital for Special Surgery, New York
 2012-08
NCT01750554 COMPLETED
Patients Undergoing Spine Surgery
University of California, San Francisco
 2012-12
NCT01305603 COMPLETED
Pain, Postoperative
Bispebjerg Hospital
 2011-02
NCT01838707 COMPLETED
Pain
Assiut University
 2007-12 PHASE2
NCT01133119 COMPLETED
Pain
The Hospital for Sick Children
 2010-02 PHASE2
NCT01756443 COMPLETED
Open Reduction Internal Fixation(ORIF) of Lateral Malleolus
Cork University Hospital
 2011-08 PHASE4
NCT01843296 COMPLETED
Lumbar Spine Disc Herniation
Isfahan University of Medical Sciences
 2012-11 PHASE4
NCT01688596 COMPLETED
Pain, Postoperative
Milton S. Hershey Medical Center
 2012-09 PHASE1
NCT01582490 COMPLETED
Mammoplasty; Postoperative Pain
Pacira Pharmaceuticals, Inc
 2012-04 PHASE4
NCT01509638 COMPLETED
Retraction of Colostomy
Pacira Pharmaceuticals, Inc
 2012-03 PHASE4
NCT01832675 COMPLETED
Application Site Discomfort
Ove Andersen
 2012-03 PHASE2
NCT01507233 TERMINATED
Bowel Obstruction
Pacira Pharmaceuticals, Inc
 2012-05 PHASE4
NCT00801047 COMPLETED
Labor; Pain
Hadassah Medical Organization
 2010-02 PHASE4
NCT01548794 COMPLETED
Anesthesia; Inguinal Hernia
Diskapi Teaching and Research Hospital
 2012-03 PHASE4
NCT01921361 COMPLETED
Perioperative/Postoperative Complications
TC Erciyes University
 2011-01 PHASE4
NCT01184794 COMPLETED
Post Operative Analgesia
Ashford and St. Peter's Hospitals NHS Trust
 2009-08 PHASE3
NCT00484731 COMPLETED
Chronic Pain
Luzerner Kantonsspital
 2006-07
NCT01404442 COMPLETED
Post Operative Pain
Qazvin University Of Medical Sciences
 2011-05 PHASE1; PHASE2
NCT01172197 TERMINATED
Pain; Arthroplasty, Replacement, Knee
NHS Tayside
 2009-01 PHASE4
NCT01342562 COMPLETED
Benign Prostatic Hypertrophy
Yonsei University
 2010-11
NCT00887003 COMPLETED
Chronic Low Back Pain
McMaster University
 2005-05
NCT01091766 COMPLETED
Anaesthesia; Toxicity
University Children's Hospital, Zurich
 2010-03 PHASE4
NCT01675895 COMPLETED
Benign Prostate Hyperplasia
Diskapi Teaching and Research Hospital
 2009-07 PHASE4
NCT01264575 COMPLETED
Spinal Anesthesia; Total Knee Replacement Arthroplasty
Seoul Medical Center
 2009-12
NCT00970086 TERMINATED
Postoperative Pain; Reaction; Anesthesia
University Hospital, Basel, Switzerland
 2009-08 PHASE4
NCT00801138 TERMINATED
Anesthesia, Local; Shoulder Surgery
The Cleveland Clinic
 2008-11
NCT01559740 COMPLETED
Postoperative Pain
Ann & Robert H Lurie Children's Hospital of Chicago
 2010-07 PHASE2
NCT00927888 COMPLETED
Pain, Postoperative
Stanford University
 2007-08 PHASE4
NCT00871442 WITHDRAWN
Labor Pain
Neil Roy Connelly, MD
 2009-05 PHASE3
NCT01528722 COMPLETED
Cholecystitis; Gall Stone Pancreatitis
University Hospitals Coventry and Warwickshire NHS Trust
 2009-01
NCT00578136 COMPLETED
Umbilical Hernia
Children's Hospital of Philadelphia
 2006-11
NCT03713762 COMPLETED
Anesthesia, Local
Centro Medico Docente la Trinidad
 2009-10-01 PHASE3
NCT01858090 COMPLETED
Elective Caesarean Section Surgeries
Baskent University
 2009-01 PHASE3
NCT00485693 COMPLETED
Postoperative Pain
Pacira Pharmaceuticals, Inc
 2007-06 PHASE2
NCT00792311 COMPLETED
Pain
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
 2008-11
NCT00523289 UNKNOWN
Injuries, Hand; Anesthesia Conduction; Anesthetics, Local
University of Sao Paulo
 2007-10 PHASE4
NCT00749749 COMPLETED
Pain, Postoperative
Innocoll
 2008-09-10 PHASE2
NCT00405262 COMPLETED
Postoperative Pain
The Hospital for Sick Children
 2006-05 PHASE3
NCT02343432 COMPLETED
Pain
Neslihan Uztüre
 2008-03
NCT00895843 COMPLETED
Postoperative Pain; Wisdom Tooth
University of Manchester
 2006-11
NCT00472134 COMPLETED
Hernia, Ventral
University Hospitals Cleveland Medical Center
 2005-12
NCT02430090 COMPLETED
Anesthesia
Ankara City Hospital Bilkent
 2006-11 PHASE2
NCT00296751 COMPLETED
Labor Pain
Rambam Health Care Campus
 2006-03
NCT00636415 COMPLETED
Analgesia
Federal University of São Paulo
 2004-06
NCT00001088 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
 1997-07 PHASE1
NCT00437996 COMPLETED
Normal Pregnancy
Hospices Civils de Lyon
 2007-02 PHASE3
NCT00287326 TERMINATED
Pain
University of North Carolina, Chapel Hill
 2006-01 PHASE3
NCT00332735 COMPLETED
Spinal Anesthesia
Reinier de Graaf Groep
 2006-05 PHASE3
NCT00195312 TERMINATED
HIV Infections
Wyeth is now a wholly owned subsidiary of Pfizer
 2005-08 PHASE1

(data from https://clinicaltrials.gov, updated on 2025-04-03)

Check the Bupivacaine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Bupivacaine functions as a potent voltage-gated sodium channel blocker that binds to the intracellular subunit of sodium channels, preventing sodium ion influx and blocking action potential conduction along nerve fibers. This inhibition of neuronal signal transmission prevents nociceptive signaling, providing effective local anesthesia and postoperative pain relief across clinical settings such as regional nerve blocks and surgical analgesia.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.