Bronopol SDS/MSDS (Safety Data Sheet)

3.1 Substances
Product name: Bronopol
CAS Number: 52-51-7
PubChem CID: 2450
Molecular formula: C3H6BrNO4
Molecular weight: 199.99 g/mol
IUPAC name: 2-bromo-2-nitropropane-1,3-diol

3.2 Mixtures
Not applicable (pure substance).

4.1 Description of first aid measures
Inhalation: Fresh air, rest.
Skin contact: Remove contaminated clothes. Rinse skin with plenty of water or shower.
Eye contact: First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion: Rinse mouth. Refer for medical attention .

4.2 Most important symptoms and effects, both acute and delayed
See Section 11 (Toxicological Information).

4.3 Indication of any immediate medical attention and special treatment needed
Treat symptomatically. Contact a poison control center or physician for severe exposure.

5.1 Extinguishing media
Suitable: Dry chemical, carbon dioxide (CO2), alcohol-resistant foam, water spray.
Unsuitable: High-pressure water jet (may spread fire).

5.2 Specific hazards arising from the substance or mixture
Excerpt from ERG Guide 133 [Flammable Solids]:
SMALL FIRE: Dry chemical, CO2, sand, earth, water spray or regular foam.
LARGE FIRE: Water spray, fog or regular foam. If it can be done safely, move undamaged containers away from the area around the fire.
FIRE INVOLVING METAL PIGMENTS OR PASTES (E.G. "ALUMINUM PASTE"): Aluminum Paste fires should be treated as a combustible metal fire. Use DRY sand, graphite powder, dry sodium chloride-based extinguishers or class D extinguishers. Also, see ERG Guide 170.
FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Cool containers with flooding quantities of water until well after fire is out. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. (ERG, 2024)
Use water spray, powder, alcohol-resistant foam, carbon dioxide.
Wear self contained breathing apparatus for fire fighting if necessary.
Use water spray to cool unopened containers.
Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Powder, alcohol-resistant foam, water spray, carbon dioxide.

5.3 Advice for firefighters
Wear self-contained breathing apparatus (SCBA) and full protective clothing.
Fight fire from upwind. Cool containers with water spray until fire is extinguished.
Flash point: 167 °C

6.1 Personal precautions, protective equipment and emergency procedures
Wear appropriate personal protective equipment (see Section 8).
Avoid breathing dust/vapor. Ensure adequate ventilation.
Evacuate personnel to safe areas. Keep people away from and upwind of spill.
WARNING: Highly toxic — only trained personnel should handle spills.

6.2 Environmental precautions
Prevent product from entering drains, waterways, or soil.
Contain spill with inert absorbent material.

6.3 Methods and materials for containment and cleaning up
· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.
· Keep unauthorized personnel away.
· Stay upwind, uphill and/or upstream.
· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.
· Do not touch or walk through spilled material.
Small Dry Spill
· With clean shovel, place material into clean, dry container and cover loosely; move containers from spill area.
Large Spill
· Wet down with water and dike for later disposal.
· Prevent entry into waterways, sewers, basements or confined areas.
Excerpt from ERG Guide 133 [Flammable Solids]:
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 25 meters (75 feet) in all directions.
LARGE SPILL: Consider initial downwind evacuation for at least 100 meters (330 feet).
FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
Immediate precautionary measure
· Isolate spill or leak area for at least 25 meters (75 feet) in all directions.
Large Spill
· Consider initial downwind evacuation for at least 100 meters (330 feet).
Fire
· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Sweep up and shovel. Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations ... Keep in suitable, closed containers for disposal. Contain spillage, pick up with an electrically protected vacuum cleaner or by wet-brushing and transfer to a container for disposal according to local regulations ... .
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.
Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. (Extra personal protection: P2 filter respirator for harmful particles).
SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.
Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging: Dispose of as unused product.
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Keep away from sources of ignition - No smoking. Keep away from heat and sources of ignition.
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.
Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

7.1 Precautions for safe handling
Excerpt from ERG Guide 133 [Flammable Solids]:
ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. Do not touch or walk through spilled material.
SMALL DRY SPILL: With clean shovel, place material into clean, dry container and cover loosely; move containers from spill area.
LARGE SPILL: Wet down with water and dike for later disposal. Prevent entry into waterways, sewers, basements or confined areas. (ERG, 2024)
Fireproof. Separated from food and feedstuffs and incompatible materials. See Chemical Dangers. Dry. Well closed. Keep in a well-ventilated room. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.
Keep container tightly closed in a dry well-ventilated place.
Separated from food and feedstuffs and incompatible materials. Dry. Well closed. Keep in a well-ventilated room.
Keep away from heat, sparks, and open flames. Use explosion-proof equipment.

7.2 Conditions for safe storage, including any incompatibilities
Fireproof. Separated from food and feedstuffs and incompatible materials. See Chemical Dangers. Dry. Well closed. Keep in a well-ventilated room. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.
Keep container tightly closed in a dry well-ventilated place.
Separated from food and feedstuffs and incompatible materials. Dry. Well closed. Keep in a well-ventilated room.
Store away from incompatible materials (see Section 10).
[Note: Specific storage temperature not available in public databases. Refer to supplier Certificate of Analysis (COA) for exact storage conditions.]

9.1 Information on basic physical and chemical properties
a) Appearance: 2-bromo-2-nitropropane-1,3-diol appears as white crystals. Ignite easily and burn readily. May detonate under strong shock. Decomposes when heated, evolving toxic gases. Toxic by skin absorption, inhalation or ingestion.
b) Odor: Odorless
c) Odor threshold: No data available
d) pH: No data available
e) Melting point/freezing point: 266 to 271 °F (NTP, 1992)
f) Initial boiling point and boiling range: 305.1 °F at 760 mmHg (NTP, 1992)
g) Flash point: 167 °C
h) Evaporation rate: No data available
i) Flammability (solid, gas): No data available
j) Upper/lower flammability or explosive limits: No data available
k) Vapor pressure: 1.2601e-05 mmHg at 68 °F (NTP, 1992)
l) Vapor density: No data available
m) Relative density: Relative density (water = 1): 1.9
n) Water solubility: greater than or equal to 100 mg/mL at 63 °F (NTP, 1992)
o) Partition coefficient: n-octanol/water: Log P (n-octanol/water): -0.6
p) Auto-ignition temperature: No data available
q) Decomposition temperature: No data available
r) Viscosity: No data available
s) Explosive properties: No data available
t) Oxidizing properties: No data available

9.2 Other information
Topological Polar Surface Area (TPSA): 86.3 Ų
Complexity: 107

11.1 Information on toxicological effects
Acute toxicity:
No acute toxicity data available.
Skin corrosion/irritation:
Causes severe skin burns and eye damage (H314).
Serious eye damage/eye irritation:
Causes serious eye damage (H318).
Respiratory or skin sensitization:
No data available.
Germ cell mutagenicity:
No data available.
Carcinogenicity:
No data available.
Reproductive toxicity:
No data available.
Specific target organ toxicity (single exposure):
H370, H373
Specific target organ toxicity (repeated exposure):
No data available.
Aspiration hazard:
No data available.

11.2 Additional information
Carcinogen classification:
No indication of carcinogenicity (not listed by IARC). (L135)
Exposure routes:
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.
Oral (A2881) ; inhalation (A2881) ; dermal (A2881)
Signs and symptoms of exposure:
Cough. Sore throat.
Redness.
Redness. Stinging sensation. Pain. Burns.
Sore throat. Tingling sensation.
Data source: Hazardous Substances Data Bank (HSDB) via PubChem.

12.1 Toxicity
LD50; Species: Anas platyrhynchos (Mallard duck) oral 509.5 mg/kg /99.4% a.i./ /from table/
LC50; Species: Anas platyrhynchos (Mallard duck) oral >10,000 ppm /in the diet/ for 8 days /100% a.i./ /from table/
LC50; Species: Colinus virginianus (Northern bobwhite) oral 4487.6 ppm /in the diet/ /8 days /100% a.i./ /from table/
LC50; Species: Oncorhynchus mykiss (Rainbow trout); Conditions: flow through; Concentration: 41.6 ppm for 96 hr (95% confidence interval: 36-45 ppm) /100% a.i./ /from table/
For more Ecotoxicity Values (Complete) data for BRONOPOL (9 total), please visit the HSDB record page.
The substance is very toxic to aquatic organisms. The substance may cause long-term effects in the aquatic environment.
Bronopol's production and use as a preservative for cosmetics and pharmaceuticals may result in its release to the environment through various waste streams; its use as an agricultural bacteriostat will result in its direct release to the environment. If released to air, a vapor pressure of 1.26X10-5 mm Hg at 20 °C indicates bronopol will exist in both the vapor and particulate phases in the atmosphere. Vapor-phase bronopol will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 11 days. Particulate-phase bronopol will be removed from the atmosphere by wet and dry deposition. Bronopol rapidly photodegrades at pH 4 exhibiting a photolysis half-life of 24 hours in water; u

12.2 Persistence and degradability
No data available.

12.3 Bioaccumulative potential
Log P (n-octanol/water): -0.6
Low potential for bioaccumulation (Log P < 3).

12.4 Mobility in soil
No data available.

12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available.

12.6 Other adverse effects
This substance is classified as hazardous to the aquatic environment.

13.1 Waste treatment methods
Waste Treatment Methods: Waste material must be disposed of in accordance with national and local regulations. Leave chemicals in original containers and do not mix with other waste. Handle uncleaned containers in the same manner as the product itself.

14.1 UN number
UN 3241

14.2 UN proper shipping name
2-Bromo-2-nitropropane-1,3-diol

14.3 Transport hazard class(es)
Class 4.1
IMO classification: Class 4.1
DOT label: Flammable Solid

14.4 Packing group
Packing group III

14.5 Environmental hazards
Marine pollutant: Yes (classified as environmentally hazardous per GHS).

14.6 Special precautions for user
Transport in original packaging. Ensure containers are tightly sealed.
For bulk or commercial quantities, consult applicable transport regulations (DOT, IATA, IMDG).
DOT Emergency Response Guide (ERG) number: 133

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable.

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
US EPA / TSCA: Subject to EPA TSCA regulations
EU ECHA / REACH: Registered (REACH Active)

SARA 302 Components:
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components:
This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards:
Acute (short-term) health hazard
Chronic (long-term) health hazard
Environmental hazard
Fire hazard

Massachusetts Right To Know Components:
This material contains components subject to the Massachusetts Right to Know Act. See Section 2 for hazard classification.
Pennsylvania Right To Know Components:
This material contains components subject to the Pennsylvania Right to Know Act. See Section 2 for hazard classification.
New Jersey Right To Know Components:
This material contains components subject to the New Jersey Right to Know Act. See Section 2 for hazard classification.

California Prop. 65 Components:
This product does not contain any chemicals known to the State of California to cause cancer, birth defects, or any other reproductive harm.

Other regulatory listings:
- The Australian Inventory of Industrial Chemicals: Chemical: 1,3-Propanediol, 2-bromo-2-nitro-
- Status Regulation (EC): 2002/2076
- FIFRA Requirements: Residues of 2-ethyl-1-hexanol are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest. Use: In-can preser
- FDA Requirements: 2-Bromo-2-nitro-1,3-propanediol is an indirect food additive for use only as a component of adhesives. Limit: For use only as an antibacterial preservative.

15.2 Chemical safety assessment
A chemical safety assessment has not been carried out for this substance.
For research-use-only compounds, no CSA is required under REACH Annex I.

Revision Date: 2026/09/09
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.