CAS No. 2270879-17-7

Batch: Purity:99.88
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BRM/BRG1 ATP Inhibitor-1 (BRM014) Chemical Structure
Chemical Structure
Check the BRM/BRG1 ATP Inhibitor-1 (BRM014) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-[3-(difluoromethyl)-1,2-thiazol-5-yl]-3-[2-fluoro-5-(hydroxymethyl)-4-pyridinyl]urea
CAS Number 2270879-17-7
Molecular Formula

C11H9F3N4O2S
Molecular Weight (MW) 318.27
InChIKey CKYCAIAVJIFWPE-UHFFFAOYSA-N

Ordering Information

Biological Activity

BRM/BRG1 ATP Inhibitor-1 (BRM is an orally active, allosteric dual inhibitor of Brahma Homolog (BRM)/SMARCA2 and Brahma-related gene 1 (BRG1)/SMARCA4 ATPase activity. By disrupting the catalytic ATPases of the SWI/SNF chromatin remodeling complex, the compound suppresses BRM-dependent transcriptional regulation, leading to downstream antiproliferative responses and significant tumor growth inhibition in BRG1-mutant cancer xenograft models. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 64 mg/mL (201.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 64 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.