CAS No. 96187-53-0

Batch: Purity:99.88
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Brequinar (DUP785) Chemical Structure
Chemical Structure
Check the Brequinar (DUP785) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid
CAS Number 96187-53-0
Molecular Formula

C23H15F2NO2
Molecular Weight (MW) 375.37
SMILES CC1=C(C2=C(C=CC(=C2)F)N=C1C3=CC=C(C=C3)C4=CC=CC=C4F)C(=O)O
InChIKey PHEZJEYUWHETKO-UHFFFAOYSA-N

Ordering Information

Biological Activity

Brequinar is a potent inhibitor of dihydroorotate dehydrogenase (DHODH), a key enzyme in de novo pyrimidine synthesis. By blocking DHODH activity within the mitochondrial pyrimidine pathway, Brequinar depletes intracellular pyrimidine nucleotide pools. This metabolic inhibition suppresses DNA and RNA synthesis, leading to cell cycle arrest, myeloid cell differentiation, and the inhibition of cellular proliferation across multiple cancer cell lines. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 9 mg/mL (23.97 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.