CAS No. 722494-26-0
Batch:
Purity:99.53
Chemical Structure
Check the
bpV (HOpic)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | potassium;(E)-hydroxy-(5-oxo-2-pyridinylidene)methanolate;oxovanadium;diperoxide | |
|---|---|---|
| CAS Number | 722494-26-0 | |
| Molecular Formula |
C6H4NO8V.2K |
|
| Molecular Weight (MW) | 347.24 | |
| SMILES | [K+].[K+].OC1=CC=C2N(=C1)|[V+3]|3|4(|[O-][O-]|3)(|[O-][O-]|4)(|[O-]C2=O)=O | |
| InChIKey | JYRQLHHGDQXCCJ-UHFFFAOYSA-M |
bpV (HOpic) is a potent, cell-permeable inhibitor of PTEN, exhibiting approximately 350-fold and 1800-fold higher IC50 values for PTP-β and PTP-1B, respectively. By inhibiting PTEN phosphatase activity, it increases intracellular phosphatidylinositol 3,4,5-trisphosphate levels and promotes activation of the downstream PI3K/AKT signaling pathway, thereby influencing cellular survival and growth processes. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 69 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.