CAS No. 394730-60-0

Batch: Purity:97
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Boceprevir Chemical Structure
Chemical Structure
Check the Boceprevir product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1R,2S,5S)-N-(4-amino-1-cyclobutyl-3,4-dioxobutan-2-yl)-3-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
CAS Number 394730-60-0
Molecular Formula

C27H45N5O5
Molecular Weight (MW) 519.68
SMILES CC1(C2C1C(N(C2)C(=O)C(C(C)(C)C)NC(=O)NC(C)(C)C)C(=O)NC(CC3CCC3)C(=O)C(=O)N)C
InChIKey LHHCSNFAOIFYRV-DOVBMPENSA-N

Ordering Information

Biological Activity

Boceprevir is an orally bioavailable hepatitis C virus (HCV) protease inhibitor that targets the HCV NS3 serine protease with a Ki value of 14 nM. By reversibly binding to the active site of the NS3 protease, it blocks essential polyprotein cleavage required for viral maturation. This inhibition disrupts viral RNA replication complexes and suppresses HCV polyprotein processing in infected host cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (192.42 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.