CAS No. 21102-95-4
| CAS Number | 21102-95-4 | |
|---|---|---|
| Molecular Formula |
C22H31N3O3.2HCl |
|
| Molecular Weight (MW) | 458.42 | |
| SMILES | COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)CC4(CCCC4)CC3=O.Cl.Cl |
BMY 7378 Dihydrochloride is a selective α1D-adrenoceptor antagonist and a 5-HT1A receptor partial agonist/antagonist. It selectively binds and inhibits α1D-adrenoceptors over other adrenergic receptor subtypes, modulating vascular tone and smooth muscle contraction. Additionally, BMY 7378 interacts with 5-HT1A serotonin receptors to regulate serotonergic neurotransmission and downstream signaling pathways. These selective pharmacological actions make it a valuable tool for distinguishing α1D-adrenoceptor function in cardiovascular and central nervous system research. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
92 mg/mL
(200.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 92 mg/mL |
| Ethanol | 20 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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- BMY 7378 Dihydrochloride Solubility in DMSO
- BMY 7378 Dihydrochloride Stock Solution
- BMY 7378 Dihydrochloride Storage
- BMY 7378 Dihydrochloride Stability
- BMY 7378 Dihydrochloride Molecular Weight
- BMY 7378 Dihydrochloride SMILES
- BMY 7378 Dihydrochloride Chemical Structure (2D and 3D)
- BMY 7378 Dihydrochloride SDS｜MSDS