CAS No. 1643368-58-4
Batch:
Purity:99.76
Chemical Structure
Check the
BMS-986142
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (7S)-3-fluoro-4-[3-(8-fluoro-1-methyl-2,4-dioxoquinazolin-3-yl)-2-methylphenyl]-7-(2-hydroxypropan-2-yl)-6,7,8,9-tetrahydro-5H-carbazole-1-carboxamide | |
|---|---|---|
| CAS Number | 1643368-58-4 | |
| Molecular Formula |
C32H30F2N4O4 |
|
| Molecular Weight (MW) | 572.60 | |
| SMILES | CC1=C(C=CC=C1N2C(=O)C3=C(C(=CC=C3)F)N(C2=O)C)C4=C(C=C(C5=C4C6=C(N5)CC(CC6)C(C)(C)O)C(=O)N)F | |
| InChIKey | ZRYMMWAJAFUANM-INIZCTEOSA-N |
BMS-986142 is a potent and reversible inhibitor of BTK that demonstrates high selectivity across a panel of 384 kinases. Inhibition of BTK blocks B-cell receptor signaling pathways, suppressing downstream activation, cytokine production, and cell proliferation in B lymphocytes and myeloid cells. Consequently, BMS-986142 attenuates inflammatory responses and autoimmune pathogenesis in preclinical disease models. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(174.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.