CAS No. 313669-88-4
Batch:
Purity:98.87
Chemical Structure
Check the
BMS-986122
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 313669-88-4 | |
|---|---|---|
| Molecular Formula |
C16H15BrClNO3S2 |
|
| Molecular Weight (MW) | 448.78 | |
| SMILES | COC1=CC=C(C=C1Br)C2SCCN2[S](=O)(=O)C3=CC=C(Cl)C=C3 |
BMS-is a selective positive allosteric modulator (PAM) of the µ-opioid receptor (µ-OR). It potentiates orthosteric agonist-mediated G protein activation, adenylyl cyclase inhibition, and β-arrestin recruitment, as well as DAMGO-stimulated [S]GTPγS binding in brain membranes. This positive modulation enhances endogenous opioid signaling pathways, downstream inhibiting GABA release in the periaqueductal gray to promote antinociceptive responses. [1][2]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
90 mg/mL
(200.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.