CAS No. 1257213-50-5
| CAS Number | 1257213-50-5 | |
|---|---|---|
| Molecular Formula |
C29H26N2O5 |
|
| Molecular Weight (MW) | 482.53 | |
| SMILES | CC(OC(=O)NC1=C(ON=C1C)C2=CC=C(C=C2)C3=CC=C(C=C3)C4(CC4)C(O)=O)C5=CC=CC=C5 |
BMS-986020 is a potent and selective antagonist of lysophosphatidic acid receptor 1 (LPA1). Inhibition of LPA1 disrupts downstream signaling pathways that drive fibroblast recruitment, vascular leak, and extracellular matrix accumulation following tissue injury. By suppressing these pro-fibrotic cellular responses, LPA1 antagonism attenuates lung injury and disease progression, highlighting its therapeutic potential in idiopathic pulmonary fibrosis. [1][2]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
97 mg/mL
(201.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 97 mg/mL |
| Water | Insoluble |
| DMSO |
97 mg/mL
(201.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 12 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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