CAS No. 445430-58-0

Batch: Purity:99.79
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BMS-345541 Chemical Structure
Chemical Structure
Check the BMS-345541 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N'-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)ethane-1,2-diamine
CAS Number 445430-58-0
Molecular Formula

C14H17N5
Molecular Weight (MW) 255.32
SMILES CC1=CC2=C(C=C1)N=C(C3=NC=C(N23)C)NCCN
InChIKey PSPFQEBFYXJZEV-UHFFFAOYSA-N

Biological Activity

BMS-345541 is a selective allosteric inhibitor of catalytic subunits IKK-2 (IC50 0.3 μM) and IKK-1 (IC50 4 μM) in cell-free assays. By blocking kinase activity, it inhibits stimulus-induced IκBα phosphorylation and disrupts NF-κB pathway activation. Consequently, this suppression downregulates NF-κB-dependent gene transcription, leading to reduced pro-inflammatory cytokine production, impaired cell proliferation, and enhanced apoptosis across diverse cellular models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 51 mg/mL (199.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Burke JR, et al. J Biol Chem. 2003;278(3):1450-6.

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Note: Technical data last updated: Sep 1, 2026.