Bleomycin sulfate Clinical Trials

Size	Price	Qty
10mg	USD 199
200mg	USD 1,490

Clinical Trials

Bleomycin sulfate has been investigated in numerous clinical trials across Phases 1 through 4 for a broad spectrum of oncologic and vascular disorders. Key conditions studied include pediatric and adult germ cell tumors, Hodgkin lymphoma, AIDS-related Kaposi sarcoma, ovarian neoplasms, and vascular malformations. Sponsored by hospital networks, academic medical centers, and cooperative research entities such as the Children's Oncology Group and the AIDS Malignancy Consortium, these trials encompass recruitment statuses ranging from active to completed.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07579962	NOT_YET_RECRUITING	Vascular Malformations	Institute of Oncology Ljubljana	2026-06-30	PHASE2
NCT05675410	RECRUITING	Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8	National Cancer Institute (NCI)	2023-05-11	PHASE3
NCT04685616	RECRUITING	Hodgkin Lymphoma	University College, London	2022-04-14	PHASE3
NCT02582697	RECRUITING	Germ Cell Tumor	University of Sydney	2014-02	PHASE3
NCT06691009	NOT_YET_RECRUITING	Malignant Pleural Effusion	Assiut University	2024-12-10
NCT03067181	RECRUITING	Childhood Extracranial Germ Cell Tumor; Extragonadal Embryonal Carcinoma; Germ Cell Tumor; Malignant Germ Cell Tumor; Malignant Ovarian Teratoma; Stage I Ovarian Choriocarcinoma; Stage I Ovarian Embryonal Carcinoma AJCC v6 and v7; Stage I Ovarian Yolk Sac Tumor AJCC v6 and v7; Stage I Testicular Choriocarcinoma AJCC v6 and v7; Stage I Testicular Embryonal Carcinoma AJCC v6 and v7; Stage I Testicular Seminoma AJCC v6 and v7; Stage I Testicular Yolk Sac Tumor AJCC v6 and v7; Stage II Ovarian Choriocarcinoma; Stage II Ovarian Embryonal Carcinoma AJCC v6 and v7; Stage II Ovarian Yolk Sac Tumor AJCC v6 and v7; Stage II Testicular Choriocarcinoma AJCC v6 and v7; Stage II Testicular Embryonal Carcinoma AJCC v6 and v7; Stage II Testicular Yolk Sac Tumor AJCC v6 and v7; Stage III Ovarian Choriocarcinoma; Stage III Ovarian Embryonal Carcinoma AJCC v6 and v7; Stage III Ovarian Yolk Sac Tumor AJCC v6 and v7; Stage III Testicular Choriocarcinoma AJCC v6 and v7; Stage III Testicular Embryonal Carcinoma AJCC v6 and v7; Stage III Testicular Yolk Sac Tumor AJCC v6 and v7; Stage IV Ovarian Choriocarcinoma; Stage IV Ovarian Embryonal Carcinoma AJCC v6 and v7; Stage IV Ovarian Yolk Sac Tumor AJCC v6 and v7; Testicular Mixed Choriocarcinoma and Embryonal Carcinoma; Testicular Mixed Choriocarcinoma and Teratoma; Testicular Mixed Choriocarcinoma and Yolk Sac Tumor	Children's Oncology Group	2017-05-25	PHASE3
NCT07041749	NOT_YET_RECRUITING	Warts of Foot	Assiut University	2026-06-01
NCT01873326	ACTIVE_NOT_RECRUITING	Germ Cell Tumors	Memorial Sloan Kettering Cancer Center	2013-06	PHASE2
NCT02341989	ACTIVE_NOT_RECRUITING	Testicular Neoplasms; Seminoma	St. Olavs Hospital	2015-04-08	PHASE3
NCT03755804	ACTIVE_NOT_RECRUITING	Hodgkin Lymphoma	St. Jude Children's Research Hospital	2018-12-12	PHASE2
NCT03033914	ACTIVE_NOT_RECRUITING	Hodgkin Lymphoma	Memorial Sloan Kettering Cancer Center	2017-01-25	PHASE1; PHASE2
NCT06647342	RECRUITING	Cutaneous Metastasis; Cutaneous Malignant Mixed Tumor; Bleomycin Adverse Reaction; Electrochemotherapy	Julie Gehl	2024-10-29	PHASE4
NCT04638790	RECRUITING	Hodgkin Lymphoma, Adult	State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia	2020-02-01	PHASE3
NCT03407144	ACTIVE_NOT_RECRUITING	Hodgkin Lymphoma	Merck Sharp & Dohme LLC	2018-04-09	PHASE2
NCT07197541	ACTIVE_NOT_RECRUITING	Plantar Wart	Second Affiliated Hospital, Zhejiang University, School of Medicine	2025-10-01	PHASE4
NCT06388252	ENROLLING_BY_INVITATION	Cutaneous Malignant Melanoma	Institute of Oncology Ljubljana	2023-11-10
NCT07258199	ENROLLING_BY_INVITATION	Nodular Goiter	Peking Union Medical College Hospital	2025-09-01
NCT06144736	RECRUITING	Seminoma	Heinrich-Heine University, Duesseldorf	2023-08-28	PHASE2
NCT07320001	NOT_YET_RECRUITING	Lymphatic Abnormality	Basharat Hussain	2026-01-26	PHASE2
NCT07728825	COMPLETED	Vascular Malformations; Venous Malformation; Lymphatic Malformation	University Of Anbar	2025-08-25	PHASE4
NCT07201766	NOT_YET_RECRUITING	Keloids Scars	King Edward Medical University	2025-12-02
NCT06437158	RECRUITING	Lymphatic Malformation	West China Hospital	2023-03-08	PHASE2
NCT04760327	RECRUITING	Gynecological Cancers	Institute of Oncology Ljubljana	2020-07-01	PHASE2
NCT07246928	COMPLETED	Intralesional Injection of Cystic Hygroma; Cystic Hygroma (Macro-cystic Lymphatic Malformation)	Delta University for Science and Technology	2024-09-01
NCT07320430	COMPLETED	Vascular Malformation	Ain Shams University	2024-02-14
NCT06718192	RECRUITING	Verruca Plantaris	The Fourth Affiliated Hospital of Zhejiang University School of Medicine	2024-12-25	PHASE1; PHASE2
NCT02429700	RECRUITING	Ovarian Sex Cord Stromal Tumor; Ovarian Neoplasms; Ovarian Cancer	Beihua Kong	2015-04	PHASE3
NCT02429687	RECRUITING	Ovarian Germ Cell Cancer; Ovarian Neoplasms; Ovarian Cancer	Beihua Kong	2015-04	PHASE3
NCT05395962	RECRUITING	Vulvar Cancer	IRCCS Azienda Ospedaliero-Universitaria di Bologna	2022-04-08	PHASE2
NCT07189832	COMPLETED	Lymphatic Malformations	Delta University for Science and Technology	2024-09-01
NCT07171827	COMPLETED	Anti-CD30; Brentuximab; Doxorubicin; Vinblastine; Dacarbazine; Frontline; Advanced Classical Hodgkin Lymphoma	Helwan University	2023-03-01
NCT07104526	COMPLETED	Infantile Hemangioma (IH)	Wuhan Integrated Traditional Chinese and Western Medicine Hospital	2024-01-01
NCT05916690	UNKNOWN	Vulvar Cancer	Institute of Oncology Ljubljana	2021-03-01
NCT03712202	ACTIVE_NOT_RECRUITING	Ann Arbor Stage I Hodgkin Lymphoma; Ann Arbor Stage I Mixed Cellularity Classic Hodgkin Lymphoma; Ann Arbor Stage I Nodular Sclerosis Classic Hodgkin Lymphoma; Ann Arbor Stage IA Hodgkin Lymphoma; Ann Arbor Stage IB Hodgkin Lymphoma; Ann Arbor Stage II Hodgkin Lymphoma; Ann Arbor Stage IIA Hodgkin Lymphoma; Ann Arbor Stage IIB Hodgkin Lymphoma; Classic Hodgkin Lymphoma; Lymphocyte-Rich Classic Hodgkin Lymphoma; Ann Arbor Stage I Lymphocyte-Depleted Classic HL; Ann Arbor Stage II Lymphocyte-Depleted Classic HL; Ann Arbor Stage II Mixed Cellularity Classic HL; Ann Arbor Stage II Nodular Sclerosis Classic HL	City of Hope Medical Center	2018-11-28	PHASE2
NCT06744946	COMPLETED	Malignant Pleural Effusions (Mpe)- Pleurodesis; Pleurodesis	Mohamed Sabry	2024-09-01	PHASE4
NCT01347294	UNKNOWN	Venous Malformation	Oslo University Hospital	2011-08	PHASE4
NCT05008224	COMPLETED	Classical Hodgkin Lymphoma	Merck Sharp & Dohme LLC	2021-10-07	PHASE2
NCT04281290	ACTIVE_NOT_RECRUITING	Pancreas Cancer	University Medical Centre Ljubljana	2020-07-13
NCT05752435	COMPLETED	Viral Wart	Combined Military Hospital Abbottabad	2022-07-01
NCT05494710	UNKNOWN	Vascular Malformations	South Tees Hospitals NHS Foundation Trust	2020-12-01
NCT02661503	UNKNOWN	Classical Hodgkin Lymphoma	University of Cologne	2016-07	PHASE3
NCT04582305	UNKNOWN	Keloid	Erasmus Medical Center	2022-03-18	PHASE4
NCT05057663	UNKNOWN	Plantar Wart	Sohag University	2021-11-01
NCT02166463	ACTIVE_NOT_RECRUITING	Ann Arbor Stage IIB Hodgkin Lymphoma; Ann Arbor Stage IIIB Hodgkin Lymphoma; Ann Arbor Stage IVA Hodgkin Lymphoma; Ann Arbor Stage IVB Hodgkin Lymphoma; Childhood Hodgkin Lymphoma; Classic Hodgkin Lymphoma	National Cancer Institute (NCI)	2015-03-19	PHASE3
NCT06080724	COMPLETED	Comparison of Efficacy of Sclerotherapy in Infantile Hemangioma	King Edward Medical University	2021-03-22
NCT03159897	COMPLETED	Hodgkin Lymphoma	Fondazione Italiana Linfomi - ETS	2017-08-01	PHASE3
NCT02104986	COMPLETED	Extra Cranial Non Seminomateous Malignant Germ Cell Tumour	Centre Leon Berard	2014-05-12	PHASE2
NCT05023408	COMPLETED	Cutaneous Warts	Jinnah Postgraduate Medical Centre	2021-01-01	PHASE2
NCT02784054	UNKNOWN	Intracranial Non-germinomatous Germ Cell Tumor	Samsung Medical Center	2014-04	PHASE2
NCT03830385	UNKNOWN	Squamous Cell Carcinoma Of The Head And Neck	Sun Yat-sen University	2019-02-15	PHASE2
NCT04139070	UNKNOWN	Gastric Cancer	Zealand University Hospital	2020-06-15	PHASE1
NCT04046679	UNKNOWN	SCAR	Clinica Dermatologica Arbache ltda	2019-08-31	PHASE4
NCT02298283	COMPLETED	Hodgkin Lymphoma	The Lymphoma Academic Research Organisation	2015-04	PHASE2
NCT01042522	UNKNOWN	Ovarian Granulosa Cell Tumor; Ovarian Gynandroblastoma; Ovarian Sertoli-Leydig Cell Tumor; Ovarian Sex Cord Tumor With Annular Tubules; Ovarian Sex Cord-Stromal Tumor; Ovarian Sex Cord-Stromal Tumor, Not Otherwise Specified; Ovarian Steroid Cell Tumor	GOG Foundation	2010-02-08	PHASE2
NCT01356680	COMPLETED	Hodgkin Lymphoma	University of Cologne	2012-01-13	PHASE3
NCT03018626	UNKNOWN	Lymphoma, Large B-Cell, Diffuse	Nanfang Hospital, Southern Medical University	2017-07-27	PHASE3
NCT03649113	COMPLETED	Hemangioma Liver	Tehran University of Medical Sciences	2018-09-01	PHASE1
NCT02549742	UNKNOWN	Head Neck Cancer	Rigshospitalet, Denmark	2014-02	PHASE2
NCT02291133	COMPLETED	Liver Cancer	Masa Bosnjak	2014-06	PHASE1; PHASE2
NCT02758717	ACTIVE_NOT_RECRUITING	Ann Arbor Stage IB Hodgkin Lymphoma; Ann Arbor Stage II Hodgkin Lymphoma; Ann Arbor Stage IIA Hodgkin Lymphoma; Ann Arbor Stage IIB Hodgkin Lymphoma; Ann Arbor Stage III Hodgkin Lymphoma; Ann Arbor Stage IIIA Hodgkin Lymphoma; Ann Arbor Stage IIIB Hodgkin Lymphoma; Ann Arbor Stage IV Hodgkin Lymphoma; Ann Arbor Stage IVA Hodgkin Lymphoma; Ann Arbor Stage IVB Hodgkin Lymphoma; Classic Hodgkin Lymphoma	Academic and Community Cancer Research United	2016-05-13	PHASE2
NCT03628417	COMPLETED	Cutaneous Melanoma	Szeged University	2016-09-20
NCT03040180	UNKNOWN	Locally Advanced Rectal Cancer; Electrochemotherapy; Neoadjuvant Therapy; Down Staging	Zealand University Hospital	2017-01	PHASE2
NCT03477448	UNKNOWN	Warts	Assiut University	2018-04-01	PHASE4
NCT03225781	TERMINATED	Pancreatic Cancer	Universita di Verona	2017-07-01
NCT02352259	COMPLETED	Liver Metastases	Institute of Oncology Ljubljana	2013-09	PHASE2
NCT00654732	COMPLETED	Classic Hodgkin Lymphoma; Lugano Classification Stage III Hodgkin Lymphoma AJCC v8; Lugano Classification Stage IV Hodgkin Lymphoma AJCC v8	M.D. Anderson Cancer Center	2008-03-19	PHASE2
NCT00736320	UNKNOWN	Hodgkin Lymphoma	University of Cologne	2009-11	PHASE3
NCT01435018	COMPLETED	HIV-1 Infection	Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections	2013-10-01	PHASE3
NCT02883023	UNKNOWN	Capillary Malformations; Vascular Malformations	Sophie Horbach	2016-11	PHASE2
NCT02782754	UNKNOWN	Intracranial Germinoma	Samsung Medical Center	2013-01	PHASE2
NCT00577993	COMPLETED	Lymphoma	M.D. Anderson Cancer Center	1998-03-16	PHASE3
NCT05327309	COMPLETED	Hemangioma; Propranolol	Shaheed Zulfiqar Ali Bhutto Medical University	2015-05-08
NCT01712490	COMPLETED	Hodgkin Lymphoma	Takeda	2012-11-09	PHASE3
NCT02292979	COMPLETED	Hodgkin Lymphoma	The Lymphoma Academic Research Organisation	2015-03	PHASE2
NCT01941901	COMPLETED	Cutaneous Metastases	Herlev Hospital	2013-09	PHASE2
NCT01659099	TERMINATED	Diffuse Large B Cell Lymphoma CD20 Positive	The Lymphoma Academic Research Organisation	2012-09	PHASE3
NCT00822120	COMPLETED	Lymphoma; Nonneoplastic Condition	SWOG Cancer Research Network	2009-07	PHASE2
NCT00920153	TERMINATED	Lymphoma	French Innovative Leukemia Organisation	2008-05	PHASE3
NCT01132807	COMPLETED	Lymphoma	Alliance for Clinical Trials in Oncology	2010-05	PHASE2
NCT00678327	COMPLETED	Lymphoma	University College, London	2008-08-29	PHASE3
NCT01606566	TERMINATED	Recurrent Head and Neck Cancer; Carcinoma, Squamous Cell of Head and Neck	PCI Biotech AS	2012-04	PHASE2
NCT00352027	COMPLETED	Hodgkin's Lymphoma	St. Jude Children's Research Hospital	2006-07-20	PHASE2
NCT01390584	TERMINATED	Lymphoma	ECOG-ACRIN Cancer Research Group	2013-05-24	PHASE2
NCT00369681	COMPLETED	Lymphoma	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins	2006-05	PHASE2
NCT00797472	UNKNOWN	Hodgkin's Disease	American Scitech International	2011-07	PHASE2
NCT00053352	COMPLETED	Childhood Embryonal Tumor; Childhood Extracranial Germ Cell Tumor; Childhood Extragonadal Germ Cell Tumor; Childhood Malignant Ovarian Germ Cell Tumor; Childhood Malignant Testicular Germ Cell Tumor; Childhood Teratoma; Ovarian Embryonal Carcinoma; Ovarian Yolk Sac Tumor; Stage II Malignant Testicular Germ Cell Tumor; Stage IIA Ovarian Germ Cell Tumor; Stage IIB Ovarian Germ Cell Tumor; Stage IIC Ovarian Germ Cell Tumor; Stage III Malignant Testicular Germ Cell Tumor; Stage IIIA Ovarian Germ Cell Tumor; Stage IIIB Ovarian Germ Cell Tumor; Stage IIIC Ovarian Germ Cell Tumor; Testicular Choriocarcinoma and Yolk Sac Tumor; Testicular Embryonal Carcinoma	Children's Oncology Group	2003-11-03	PHASE3
NCT00918593	WITHDRAWN	Ulcerated Cutaneous Metastases	Copenhagen University Hospital at Herlev	2009-12	PHASE2
NCT01322100	TERMINATED	Brain Metastases; CNS Metastases	Copenhagen University Hospital at Herlev	2011-04	PHASE1
NCT00026208	COMPLETED	Lymphoma, Hodgkin Disease; Lymphoma; Hodgkin Disease; Lymphoma: Hodgkin	Stanford University	2001-06	PHASE2
NCT01872923	COMPLETED	Cutaneous or Sub-cutaneous Malignancies	PCI Biotech AS	2012-01	PHASE1
NCT01060904	COMPLETED	Disease, Hodgkin	Seagen Inc.	2010-01	PHASE1
NCT00025259	COMPLETED	Childhood Lymphocyte-Depleted Classical Hodgkin Lymphoma; Childhood Mixed Cellularity Classical Hodgkin Lymphoma; Childhood Nodular Lymphocyte Predominant Hodgkin Lymphoma; Childhood Nodular Sclerosis Classical Hodgkin Lymphoma; Stage I Childhood Hodgkin Lymphoma; Stage II Childhood Hodgkin Lymphoma; Stage III Childhood Hodgkin Lymphoma; Stage IV Childhood Hodgkin Lymphoma	Children's Oncology Group	2002-09	PHASE3
NCT00104676	COMPLETED	Extragonadal Germ Cell Tumor; Teratoma; Testicular Germ Cell Tumor	UNICANCER	2003-11-26	PHASE3
NCT01026220	COMPLETED	Childhood Nodular Lymphocyte Predominant Hodgkin Lymphoma; Stage III Childhood Hodgkin Lymphoma; Stage IV Childhood Hodgkin Lymphoma	Children's Oncology Group	2009-12-07	PHASE3
NCT00504504	COMPLETED	Lymphoma	M.D. Anderson Cancer Center	2001-03	PHASE2
NCT01468740	UNKNOWN	HIV-associated Hodgkin Lymphoma	Harlachinger Krebshilfe e.V.	2004-03	PHASE2
NCT01404936	COMPLETED	Lymphoma	M.D. Anderson Cancer Center	1996-07	PHASE2
NCT00003389	COMPLETED	Lymphoma	Eastern Cooperative Oncology Group	1999-06-17	PHASE3
NCT00002561	COMPLETED	Hodgkin Lymphoma	NCIC Clinical Trials Group	1994-01-25	PHASE3
NCT00993512	COMPLETED	Head and Neck Neoplasms; Skin Neoplasms	PCI Biotech AS	2009-08	PHASE1
NCT00983944	WITHDRAWN	Lymphoma	Ohio State University Comprehensive Cancer Center	2009-09	PHASE2
NCT00136565	COMPLETED	Peripheral T-cell Lymphoma	Lymphoma Study Association	2006-01-08	PHASE2
NCT00079105	COMPLETED	Lymphoma	Newcastle-upon-Tyne Hospitals NHS Trust	2004-01	PHASE2
NCT00274950	UNKNOWN	Childhood Germ Cell Tumor; Extragonadal Germ Cell Tumor; Ovarian Cancer	Children's Cancer and Leukaemia Group	2005-05	PHASE3
NCT00135499	TERMINATED	Lymphoma, Large-Cell, Diffuse	Lymphoma Study Association	2001-10-16	PHASE3
NCT00049595	COMPLETED	Lymphoma	European Organisation for Research and Treatment of Cancer - EORTC	2002-08	PHASE3
NCT01251107	COMPLETED	Hodgkin Lymphoma	Fondazione Michelangelo	2000-03	PHASE3
NCT00453232	COMPLETED	Extragonadal Germ Cell Tumor; Teratoma; Testicular Germ Cell Tumor	Cambridge University Hospitals NHS Foundation Trust	2004-08	PHASE2
NCT00198276	COMPLETED	Cancer	Inovio Pharmaceuticals	2004-02	PHASE4
NCT00198263	COMPLETED	Head and Neck Cancer	Inovio Pharmaceuticals	2004-01	PHASE4
NCT00198315	TERMINATED	Head and Neck Cancer	Inovio Pharmaceuticals	2004-06	PHASE3
NCT00003941	COMPLETED	Mediastinal Cancer; Metastatic Cancer; Testicular Germ Cell Tumor	European Organisation for Research and Treatment of Cancer - EORTC	1999-04	PHASE3
NCT00198328	TERMINATED	Head Neck Cancer	Inovio Pharmaceuticals	2004-11	PHASE3
NCT02161692	COMPLETED	Testicular Neoplasms; Germ Cell Tumors	Fondazione IRCCS Istituto Nazionale dei Tumori, Milano	1996-12	PHASE2
NCT00066482	COMPLETED	Childhood Germ Cell Tumor; Extragonadal Germ Cell Tumor	Children's Oncology Group	2004-07
NCT00002565	COMPLETED	Lymphoma	M.D. Anderson Cancer Center	1994-05-25	PHASE3
NCT00002715	COMPLETED	Lymphoma	Stanford University	1989-04	PHASE2
NCT00132613	COMPLETED	Malignant Pericardial Effusion	Japan Clinical Oncology Group	1999-08	PHASE3
NCT00006916	TERMINATED	Brain and Central Nervous System Tumors	Radiation Therapy Oncology Group	2001-06	PHASE2
NCT00284271	COMPLETED	Hodgkin´s Lymphoma	University of Cologne	2004-01	PHASE2
NCT00002524	COMPLETED	Lymphoma	M.D. Anderson Cancer Center	1993-06	PHASE2
NCT00225173	TERMINATED	Hodgkin Disease	Stanford University	2001-10	PHASE2
NCT00005090	TERMINATED	Lymphoma	SWOG Cancer Research Network	2000-04	PHASE3
NCT00002827	COMPLETED	Cardiac Toxicity; Lymphoma	Children's Oncology Group	1996-10	PHASE3
NCT00005578	COMPLETED	Cardiac Toxicity; Lymphoma	Children's Oncology Group	1997-03	PHASE3
NCT00003811	COMPLETED	Childhood Germ Cell Tumor; Drug/Agent Toxicity by Tissue/Organ; Extragonadal Germ Cell Tumor; Ovarian Cancer	Children's Oncology Group	2000-04	PHASE2
NCT00005584	ACTIVE_NOT_RECRUITING	Lymphoma	European Organisation for Research and Treatment of Cancer - EORTC	1998-10	PHASE3
NCT00002835	COMPLETED	Lymphoma	M.D. Anderson Cancer Center	1995-10-30	PHASE3
NCT00038558	COMPLETED	Hodgkin Disease	M.D. Anderson Cancer Center	2001-11	PHASE3
NCT00002571	COMPLETED	Lymphoma	SWOG Cancer Research Network	1994-06	PHASE2
NCT00002657	COMPLETED	Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm	SWOG Cancer Research Network	1995-05	PHASE2
NCT00004010	COMPLETED	Lymphoma	Children's Oncology Group	1999-10	PHASE2
NCT00002872	COMPLETED	Metastatic Cancer	Eastern Cooperative Oncology Group	1997-01-10	PHASE3
NCT00264953	COMPLETED	Hodgkin´s Lymphoma	University of Cologne	1998-05	PHASE3
NCT00265018	COMPLETED	Hodgkin´s Lymphoma	University of Cologne	1998-05	PHASE3
NCT00003110	COMPLETED	Lymphoma	Case Comprehensive Cancer Center	1997-07	PHASE2
NCT00002462	ACTIVE_NOT_RECRUITING	Lymphoma	European Organisation for Research and Treatment of Cancer - EORTC	1989-09	PHASE3
NCT00003209	COMPLETED	Cervical Cancer	European Organisation for Research and Treatment of Cancer - EORTC	1997-12	PHASE3
NCT00379041	ACTIVE_NOT_RECRUITING	Lymphoma	European Organisation for Research and Treatment of Cancer - EORTC	1993-09-01	PHASE3
NCT00000626	COMPLETED	HIV Infections; Hodgkin's Disease	National Institute of Allergy and Infectious Diseases (NIAID)		PHASE2
NCT00003262	UNKNOWN	Lymphoma	Centro di Riferimento Oncologico - Aviano	1997-05	PHASE2
NCT00002476	COMPLETED	Head and Neck Cancer	Cancer Research UK	1990-01	PHASE3
NCT00000689	COMPLETED	Lymphoma, Non-Hodgkin; HIV Infections	National Institute of Allergy and Infectious Diseases (NIAID)		PHASE1
NCT00324298	COMPLETED	Drug/Agent Toxicity by Tissue/Organ; Testicular Germ Cell Tumor	Queen Mary University of London	2003-07	PHASE3
NCT00689845	UNKNOWN	Lymphoma	University Hospital Southampton NHS Foundation Trust	2007-06
NCT00002318	UNKNOWN	Sarcoma, Kaposi; HIV Infections	Sequus Pharmaceuticals		PHASE3
NCT00000987	COMPLETED	Sarcoma, Kaposi; HIV Infections	National Institute of Allergy and Infectious Diseases (NIAID)		PHASE1
NCT00002093	COMPLETED	Sarcoma, Kaposi; HIV Infections	Nexstar Pharmaceuticals		PHASE3
NCT00031902	UNKNOWN	Lymphoma	Lymphoma Trials Office	2001-10	PHASE1
NCT00301782	COMPLETED	Extragonadal Germ Cell Tumor; Teratoma; Testicular Germ Cell Tumor	Medical Research Council	2005-06	PHASE2
NCT00002105	COMPLETED	Sarcoma, Kaposi; HIV Infections	Sequus Pharmaceuticals		PHASE3
NCT00000703	COMPLETED	Lymphoma, Non-Hodgkin; HIV Infections	National Institute of Allergy and Infectious Diseases (NIAID)
NCT00001059	COMPLETED	Sarcoma, Kaposi; HIV Infections	National Institute of Allergy and Infectious Diseases (NIAID)		PHASE2
NCT00429754	WITHDRAWN	Nausea; Vomiting	Radboud University Medical Center		PHASE4
NCT00003815	UNKNOWN	Lymphoma	Scotland and Newcastle Lymphoma Group	1994-06	PHASE3
NCT00265031	COMPLETED	Hodgkin´s Lymphoma	University of Cologne	1999-01	PHASE3
NCT00276718	UNKNOWN	Brain and Central Nervous System Tumors; Childhood Germ Cell Tumor; Extragonadal Germ Cell Tumor; Ovarian Cancer	Children's Cancer and Leukaemia Group	1989-04
NCT00002596	COMPLETED	Childhood Germ Cell Tumor; Extragonadal Germ Cell Tumor; Testicular Germ Cell Tumor	Memorial Sloan Kettering Cancer Center	1994-09	PHASE3
NCT00032149	UNKNOWN	Lymphoma	Lymphoma Trials Office	2001-10	PHASE1; PHASE2
NCT00000681	COMPLETED	Sarcoma, Kaposi; HIV Infections	National Institute of Allergy and Infectious Diseases (NIAID)		PHASE1
NCT00005867	COMPLETED	Lymphoma	Lymphoma Trials Office	1998-01	PHASE3
NCT00027521	WITHDRAWN	Pancreatic Cancer	Ichor Medical Systems Incorporated	2000-12	PHASE1
NCT00002714	COMPLETED	Lymphoma	Stanford University	1995-04	PHASE2
NCT00003643	UNKNOWN	Extragonadal Germ Cell Tumor; Teratoma; Testicular Germ Cell Tumor	European Organisation for Research and Treatment of Cancer - EORTC	1998-10	PHASE2; PHASE3
NCT00002987	UNKNOWN	Lymphoma	Medical Research Council	1997-01	PHASE3
NCT00003421	COMPLETED	Lymphoma	Medical Research Council	1998-06	PHASE3
NCT00000954	COMPLETED	Sarcoma, Kaposi; HIV Infections	National Institute of Allergy and Infectious Diseases (NIAID)		PHASE1
NCT00025064	UNKNOWN	Lymphoma	Children's Cancer and Leukaemia Group	2000-01	PHASE2
NCT00041210	UNKNOWN	Lymphoma	Mount Vernon Cancer Centre at Mount Vernon Hospital	2001-10	PHASE3
NCT00006035	UNKNOWN	Melanoma (Skin)	H. Lee Moffitt Cancer Center and Research Institute	2000-06	PHASE1
NCT00416377	UNKNOWN	Lymphoma	Children's Cancer and Leukaemia Group
NCT00000658	COMPLETED	Lymphoma, Non-Hodgkin; HIV Infections	National Institute of Allergy and Infectious Diseases (NIAID)		PHASE3

(data from https://clinicaltrials.gov, updated on 2026-05-22)

Check the Bleomycin sulfate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Bleomycin sulfate forms chelate complexes with ferrous iron that bind molecular oxygen to generate superoxide and hydroxyl free radicals, which directly induce single- and double-stranded DNA cleavage as well as oxidative membrane damage. This targeted DNA strand breakage halts DNA synthesis and arrests cellular proliferation, thereby inhibiting tumor growth and vascular progression in clinical indications such as germ cell tumors, Hodgkin lymphoma, and vascular malformations.

Appendix RUO and cGMP Quality Standards

Quality Dimension	RUO (Research Use Only)	cGMP (Current Good Manufacturing Practice)
Clinical Applicability	Prohibited in human clinical trials or medical diagnostics.	Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status	Non-regulated grade; exempt from drug manufacturing laws.	Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment	Unclassified analytical or research laboratories.	Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control	Basic purity and activity testing.	Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation	Basic equipment calibration; no process validation required.	Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance	Vendor self-declared without required formal QMS.	Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact	High risk of IND rejection if used as a critical raw material.	Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).