CAS No. 856925-71-8
Batch:
Purity:99.4
Chemical Structure
Check the
(-)-Blebbistatin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3aS)-3a-hydroxy-6-methyl-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one | |
|---|---|---|
| CAS Number | 856925-71-8 | |
| Molecular Formula |
C18H16N2O2 |
|
| Molecular Weight (MW) | 292.33 | |
| SMILES | CC1=CC2=C(C=C1)N=C3C(C2=O)(CCN3C4=CC=CC=C4)O | |
| InChIKey | LZAXPYOBKSJSEX-GOSISDBHSA-N |
(-)-Blebbistatin is a cell-permeable inhibitor targeting non-muscle myosin II ATPase with an IC50 of ~in cell-free assays. It shows high selectivity and does not inhibit myosin light chain kinase. By blocking myosin II motor activity, (-)-Blebbistatin inhibits cleavage furrow contraction during cell cytokinesis without disrupting mitosis or contractile ring assembly. [1][2]
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
39 mg/mL
(133.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
58 mg/mL
(198.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
58 mg/mL
(198.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
58 mg/mL
(198.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
58 mg/mL
(198.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- (-)-Blebbistatin Mechanism of Action: Non-muscle Myosin II Inhibition in Cancer Cell Research
- (-)-Blebbistatin: Selectivity & Specificity
- (-)-Blebbistatin Working Concentration | Cell Culture | Treatment
- (-)-Blebbistatin Solubility in DMSO
- (-)-Blebbistatin Storage
- (-)-Blebbistatin Stability
- (-)-Blebbistatin Combination Database
- (-)-Blebbistatin Molecular Weight
- (-)-Blebbistatin SMILES
- (-)-Blebbistatin Chemical Structure (2D and 3D)
- (-)-Blebbistatin IC50 for Cell-based and Cell-free Assays
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- (-)-Blebbistatin SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.