CAS No. 935693-62-2
Batch:
Purity:97.73
Chemical Structure
Check the
BIX-01294
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine | |
|---|---|---|
| CAS Number | 935693-62-2 | |
| Molecular Formula |
C28H38N6O2 |
|
| Molecular Weight (MW) | 490.64 | |
| InChIKey | OSXFATOLZGZLSK-UHFFFAOYSA-N |
BIX-01294 is a selective inhibitor of the histone methyltransferases G9a and GLP. By specifically reducing cellular histone H3 lysine 9 dimethylation (H3K9me2) levels, BIX-01294 modulates chromatin structure and epigenetic gene repression. This inhibition leads to impaired cancer cell proliferation, induction of autophagy or apoptosis, and suppression of tumor cell growth across various preclinical models. [1]
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Concentration
Volume
Mass
|
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
98 mg/mL
(199.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 98 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.