CAS No. 33171-05-0

Batch: Purity:99.86
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Bisdemethoxycurcumin (BDMC) Chemical Structure
Chemical Structure
Check the Bisdemethoxycurcumin (BDMC) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 33171-05-0
Molecular Formula

C19H16O4
Molecular Weight (MW) 308.33
SMILES C1=CC(=CC=C1C=CC(=O)CC(=O)C=CC2=CC=C(C=C2)O)O

Biological Activity

Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin that functions as a polyphenol-based anti-inflammatory and anti-cancer agent. It modulates key cellular signaling networks, including the NF-kB and MAPK pathways, leading to the downregulation of pro-inflammatory mediators such as iNOS and COX-2. Additionally, BDMC inhibits tumor cell proliferation, suppresses migration, and induces cell cycle arrest and apoptosis across various cancer models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 62 mg/mL (201.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 25 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] KimMM, et al. Food and Chemical Toxicology. 2010;48(10):2925-2933.

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Note: Technical data last updated: Sep 1, 2026.