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Birinapant is a potent pan-IAP antagonist. It affects NF-κB and apoptotic signaling by promoting cIAP auto-ubiquitylation and degradation, effectively inducing apoptosis and inhibiting tumor cell viability.
Birinapant (TL32711): Mechanism of Action
Birinapant (TL32711) MOA：Targeting cIAP1/NF-κB Pathway for Oncology Research