CAS No. 1800506-48-2

Batch: Purity:99.65
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Bireociclib (XZP-3287,CDK4/6-IN-2) Chemical Structure
Chemical Structure
Check the Bireociclib (XZP-3287,CDK4/6-IN-2) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-[(4-ethylpiperazin-1-yl)methyl]-N-[5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)-2-pyridinyl]pyrimidin-2-amine
CAS Number 1800506-48-2
Molecular Formula

C27H32F2N8
Molecular Weight (MW) 506.59
SMILES CCN1CCN(CC2=CN=C(NC3=NC=C(F)C(C4=CC(N(C(C)C)C(C)=N5)=C5C(F)=C4)=C3)N=C2)CC1
InChIKey CMOYPFUEZDEQEH-UHFFFAOYSA-N

Biological Activity

Bireociclib (XZP-3287) is a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and cyclin-dependent kinase 6 (CDK6). By selectively targeting CDK4 and CDK6, it disrupts the CDK4/6-cyclin D complex and prevents retinoblastoma (RB) protein phosphorylation. This inhibition blocks the transition from G1 to S phase in the cell cycle, leading to G1-phase arrest and suppression of cellular proliferation in cyclin D-dependent tumor models. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Ethanol 100 mg/mL
DMSO 14 mg/mL (27.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Asghar U, et al. Nat Rev Drug Discov. 2015;14(2):130-46.

[2] Sherr CJ, et al. Cancer Discov. 2016;6(4):353-67.

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Note: Technical data last updated: Sep 1, 2026.