CAS No. 667463-85-6
Batch:
Purity:99.29
Chemical Structure
Check the
BIO-acetoxime
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [(E)-[2-(6-bromo-2-hydroxy-1H-indol-3-yl)indol-3-ylidene]amino] acetate | |
|---|---|---|
| CAS Number | 667463-85-6 | |
| Molecular Formula |
C18H12BrN3O3 |
|
| Molecular Weight (MW) | 398.21 | |
| SMILES | CC(=O)ON=C1C2=CC=CC=C2N=C1C3=C(NC4=C3C=CC(=C4)Br)O | |
| InChIKey | HUDSYNWJCPDHLL-CJLVFECKSA-N |
BIO-acetoxime is a potent inhibitor of glycogen synthase kinase 3 (GSK-3), targeting both GSK-3α and GSK-3β isoforms. By inhibiting GSK-3 activity, it blocks downstream phosphorylation of substrate proteins within the Wnt/β-catenin signaling pathway. This inhibition stabilizes cytosolic β-catenin, enabling its nuclear translocation to regulate transcriptional programs involved in stem cell self-renewal and cellular differentiation. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
39 mg/mL
(97.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
19 mg/mL
(47.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.