CAS No. 2937327-93-8
Batch:
Purity:99.01
Chemical Structure
Check the
BI-2865
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (4S)-2-amino-4-methyl-4-[3-[4-[(1S)-1-[(2S)-1-methylpyrrolidin-2-yl]ethoxy]pyrimidin-2-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile | |
|---|---|---|
| CAS Number | 2937327-93-8 | |
| Molecular Formula |
C23H27N7O2S |
|
| Molecular Weight (MW) | 465.57 | |
| InChIKey | MIUFORKWYHBPRW-HMFCALDFSA-N |
BI-is a non-covalent pan-KRAS inhibitor that binds wild-type KRAS as well as KRAS G12C, KRAS G12D, KRAS G12V, and KRAS G13D mutants. By blocking nucleotide exchange, it suppresses downstream MAPK/ERK pathway signaling and inhibits cell proliferation across diverse KRAS-mutant driven cancer models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
93 mg/mL
(199.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 93 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- BI-2865 Mechanism of Action: KRAS Inhibition in Cancer Cell Research
- BI-2865: Selectivity & Specificity
- BI-2865 Working Concentration | Cell Culture | Treatment
- BI-2865 Solubility in DMSO
- BI-2865 Stock Solution
- BI-2865 Storage
- BI-2865 Stability
- BI-2865 Combination Database
- BI-2865 Molecular Weight
- BI-2865 Chemical Structure (2D and 3D)
- BI-2865 IC50 for Cell-based and Cell-free Assays
- BI-2865 Sigma (SML4151)? Try a better option.
- BI-2865 MedChemExpress (HY-153724)? Try a better option.
- BI-2865 Abmole (M40499)? Try a better option.
- BI-2865 TargetMol (T72061)? Try a better option.
- BI-2865 BPS Bioscience (82711-3)? Try a better option.
- BI-2865 SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.