CAS No. 2736508-60-2

Batch: Purity:99.48
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Catadegbrutinib (BGB-16673) Chemical Structure
Chemical Structure
Check the Catadegbrutinib (BGB-16673) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-tert-butyl-N-[(1R)-1-[4-[6-[6-[4-[[1-[4-(2,4-dioxo-1,3-diazinan-1-yl)phenyl]piperidin-4-yl]methyl]piperazin-1-yl]-3-pyridinyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2-methylphenyl]ethyl]-1,2,4-oxadiazole-5-carboxamide
CAS Number 2736508-60-2
Molecular Formula

C47H54N12O4
Molecular Weight (MW) 851.01
InChIKey ZSOLMVZWDSGPDD-SSEXGKCCSA-N

Ordering Information

Biological Activity

Catadegbrutinib (BGB-16673) is a targeted protein degrader of Bruton’s tyrosine kinase (BTK). By recruiting the ubiquitin-proteasome system to induce proteasomal degradation of BTK, it inhibits downstream B-cell receptor signaling pathways including NF-κB and AKT. This target degradation suppresses cell proliferation and survival in B-cell lymphoma models, demonstrating potent BTK depletion in whole blood and tumor xenografts. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (117.5 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.