CAS No. 473-98-3

Batch: Purity:99.51
Check CoA
Betulin Chemical Structure
Chemical Structure
Check the Betulin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 473-98-3
Molecular Formula

C30H50O2
Molecular Weight (MW) 442.72
SMILES CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)CO

Ordering Information

Biological Activity

Betulin is a natural pentacyclic lupane-type triterpenoid that acts as an inhibitor of sterol regulatory element-binding protein (SREBP). By binding SREBP cleavage-activating protein (SCAP) and facilitating its interaction with Insig, Betulin suppresses SREBP maturation and activation. This targeted inhibition impairs lipid and cholesterol biosynthesis pathways, resulting in reduced intracellular lipid accumulation and suppression of lipogenic gene expression to exhibit chemopreventive and antiproliferative phenotypes. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 7 mg/mL (15.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.