CAS No. 5579-84-0
Batch:
Purity:99.93
Chemical Structure
Check the
Betahistine 2HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-methyl-2-pyridin-2-ylethanamine;dihydrochloride | |
|---|---|---|
| CAS Number | 5579-84-0 | |
| Molecular Formula |
C8H12N2.2HCl |
|
| Molecular Weight (MW) | 209.12 | |
| SMILES | CNCCC1=CC=CC=N1.Cl.Cl | |
| InChIKey | XVDFMHARQUBJRE-UHFFFAOYSA-N |
Betahistine 2HCl is a histamine H3 receptor inhibitor that acts as an antagonist at histamine H3 receptors and an agonist at histamine H1 receptors. Inhibition of presynaptic histamine H3 receptors blocks autoinhibition, leading to increased histamine synthesis and release in the central nervous system. This enhancement of histaminergic transmission regulates local vestibular neurotransmission and promotes microvascular blood flow. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
38 mg/mL
(181.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 38 mg/mL |
| Ethanol | 38 mg/mL |
| DMSO |
38 mg/mL
(181.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 38 mg/mL |
| Ethanol | 1 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.